SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		4 / 4 ILE A 248
LEU A 184
VAL A 198
ILE A 201
 None
 0.79A 1fm6D-3qw3A:
undetectable		 1fm6D-3qw3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		5 / 12 VAL A  73
CYH A 245
LEU A 244
ALA A 241
ALA A  46
 None
 1.13A 1sa1C-3qw3A:
undetectable
1sa1D-3qw3A:
undetectable		 1sa1C-3qw3A:
18.79
1sa1D-3qw3A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		4 / 6 ILE A 248
ILE A  77
TYR A  48
LEU A 208
 None
 1.05A 3adsA-3qw3A:
undetectable		 3adsA-3qw3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		4 / 5 ASN A 138
LEU A 184
GLY A 177
THR A 109
 None
 0.94A 3dl9A-3qw3A:
undetectable		 3dl9A-3qw3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		4 / 7 ALA A  96
TYR A  95
GLY A  86
ILE A  88
 None
 0.64A 4eatA-3qw3A:
undetectable		 4eatA-3qw3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		4 / 7 PHE A 131
ASN A 171
PHE A   3
LEU A 194
 None
 0.94A 4ejgA-3qw3A:
undetectable		 4ejgA-3qw3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		4 / 8 ILE A 248
LEU A 184
ILE A 201
MET A 223
 None
 0.99A 4xtaB-3qw3A:
undetectable		 4xtaB-3qw3A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		4 / 7 ILE A  77
GLY A  76
PHE A 100
CYH A  17
 None
 0.87A 5hieA-3qw3A:
undetectable		 5hieA-3qw3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		4 / 8 ILE A  77
GLY A  76
PHE A 100
CYH A  17
 None
 0.95A 5hieD-3qw3A:
undetectable		 5hieD-3qw3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		3 / 3 VAL A  80
ARG A 161
PRO A 112
 None
SO4  A 259 (-2.3A)
None
 0.85A 5koxA-3qw3A:
undetectable		 5koxA-3qw3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)
(Leishmania
infantum) 		5 / 11 VAL A  79
ALA A 105
ASP A  21
THR A 109
ALA A 107
 None
None
SO4  A 257 ( 4.4A)
None
None
 1.45A 6dk1C-3qw3A:
undetectable		 6dk1C-3qw3A:
20.88