SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		5 / 12 THR A 342
TYR A 288
TYR A 351
ILE A 354
LEU A 281
 None
 1.32A 1z9hA-3qwtA:
0.8		 1z9hA-3qwtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		5 / 12 THR A 342
TYR A 288
TYR A 351
ILE A 354
LEU A 281
 None
 1.32A 1z9hB-3qwtA:
undetectable		 1z9hB-3qwtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		5 / 12 THR A 342
TYR A 288
TYR A 351
ILE A 354
LEU A 281
 None
 1.33A 1z9hC-3qwtA:
0.8		 1z9hC-3qwtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		4 / 8 MET A 365
ALA A 364
VAL A  30
THR A  31
 None
 0.99A 2kotB-3qwtA:
undetectable		 2kotB-3qwtA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		4 / 7 ILE A 322
ARG A 323
TYR A 377
GLU A  15
 None
 1.14A 2qebA-3qwtA:
undetectable		 2qebA-3qwtA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		4 / 7 ILE A 322
ARG A 323
TYR A 377
GLU A  15
 None
 1.16A 2qebB-3qwtA:
undetectable		 2qebB-3qwtA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		5 / 12 ILE A 325
ALA A 291
GLN A 337
LEU A 335
ILE A  18
 None
 1.15A 4nqaH-3qwtA:
undetectable		 4nqaH-3qwtA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		3 / 3 GLU A 243
TYR A 299
GLU A 372
 GOL  A 381 (-2.9A)
None
None
 0.75A 4ryaA-3qwtA:
undetectable		 4ryaA-3qwtA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		3 / 3 TYR A 299
ARG A 306
LYS A 303
 None
GOL  A 381 (-2.8A)
GOL  A 381 (-3.1A)
 1.46A 4wq5B-3qwtA:
undetectable		 4wq5B-3qwtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		4 / 7 LYS A  87
TYR A  77
TYR A  74
LEU A  70
 None
 1.25A 4yv5A-3qwtA:
undetectable		 4yv5A-3qwtA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		4 / 7 LYS A  87
TYR A  77
TYR A  74
LEU A  70
 None
 1.21A 4yv5B-3qwtA:
undetectable		 4yv5B-3qwtA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		5 / 6 LEU A 370
ILE A 322
ALA A 321
THR A 294
ALA A 291
 None
 1.33A 4zf8A-3qwtA:
undetectable		 4zf8A-3qwtA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		4 / 8 LEU A 168
ILE A 301
THR A 235
TRP A 278
 None
 1.07A 5ljbA-3qwtA:
undetectable		 5ljbA-3qwtA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		4 / 8 LEU A 374
LEU A  26
ILE A  88
THR A  31
 None
 0.98A 5ljbA-3qwtA:
undetectable		 5ljbA-3qwtA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		4 / 6 LEU A 168
ILE A 301
THR A 235
TRP A 278
 None
 1.10A 5ljeA-3qwtA:
undetectable		 5ljeA-3qwtA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		5 / 12 GLY A 230
TRP A 233
HIS A 212
PHE A 222
ASN A 221
 None
 1.50A 5lsuB-3qwtA:
undetectable		 5lsuB-3qwtA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3qwt PUTATIVE GH105
FAMILY PROTEIN
(Salmonella
enterica) 		4 / 6 ILE A 329
ALA A 366
LEU A 370
ILE A 322
 None
 0.87A 5mvmB-3qwtA:
undetectable
5mvmC-3qwtA:
undetectable		 5mvmB-3qwtA:
12.34
5mvmC-3qwtA:
12.34