SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1
(Homo
sapiens) 		4 / 5 SER A 146
SER A 150
PHE A  98
VAL A 105
 None
 1.04A 1oipA-3qxlA:
undetectable		 1oipA-3qxlA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1
(Homo
sapiens) 		5 / 12 VAL A  46
PHE A 125
ILE A 128
LEU A 132
VAL A 105
 None
 1.24A 2jn3A-3qxlA:
undetectable		 2jn3A-3qxlA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1
(Homo
sapiens) 		5 / 12 LEU A 203
ASN A  90
GLN A  70
TYR A 206
LEU A  74
 None
 1.39A 3fsuA-3qxlA:
undetectable		 3fsuA-3qxlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1
(Homo
sapiens) 		5 / 12 GLN A  57
ALA A  55
LEU A  60
ILE A  63
ASP A 250
 None
 1.17A 5vlmA-3qxlA:
undetectable		 5vlmA-3qxlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1
(Homo
sapiens) 		5 / 12 TYR A 249
LEU A 252
ILE A 200
HIS A 139
VAL A 101
 None
 1.32A 6djzB-3qxlA:
undetectable		 6djzB-3qxlA:
22.18