SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 12 PHE A 165
THR A 111
VAL A 101
ARG A 119
LEU A 159
 None
 1.21A 1cbrA-3qxzA:
undetectable		 1cbrA-3qxzA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 12 PHE A 165
THR A 111
VAL A 101
ARG A 119
LEU A 159
 None
 1.21A 1cbrB-3qxzA:
undetectable		 1cbrB-3qxzA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 9 LEU A 158
ILE A 129
LEU A 121
GLY A 109
LEU A 114
 None
 1.12A 1e7aB-3qxzA:
undetectable		 1e7aB-3qxzA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 11 LEU A  18
ASN A 102
VAL A 101
GLY A 103
LEU A  53
 None
 1.25A 1fkpA-3qxzA:
undetectable		 1fkpA-3qxzA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 11 ALA A  90
ARG A  41
GLU A   7
ALA A  14
LEU A  16
 None
 1.14A 1mjlA-3qxzA:
undetectable
1mjlB-3qxzA:
undetectable		 1mjlA-3qxzA:
21.89
1mjlB-3qxzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 10 ALA A 189
VAL A  13
VAL A  15
ILE A  51
VAL A  50
 None
 1.03A 2nnjA-3qxzA:
undetectable		 2nnjA-3qxzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 9 TYR A 127
LEU A  18
ALA A 100
LEU A  53
ALA A 113
 None
 1.16A 2vcvD-3qxzA:
undetectable		 2vcvD-3qxzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 9 TYR A 127
LEU A  18
ALA A 100
LEU A  53
ALA A 113
 None
 1.13A 2vcvE-3qxzA:
undetectable		 2vcvE-3qxzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 9 TYR A 127
LEU A  18
ALA A 100
LEU A  53
ALA A 113
 None
 1.13A 2vcvH-3qxzA:
undetectable		 2vcvH-3qxzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 9 TYR A 127
LEU A  18
ALA A 100
LEU A  53
ALA A 113
 None
 1.17A 2vcvI-3qxzA:
undetectable		 2vcvI-3qxzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 12 LEU A 175
LEU A 146
VAL A 154
ALA A 113
SER A 166
 None
 1.25A 2vmyB-3qxzA:
undetectable		 2vmyB-3qxzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 10 LEU A  18
ASN A 102
VAL A 101
GLY A 103
LEU A  53
 None
 1.26A 3lp1A-3qxzA:
undetectable		 3lp1A-3qxzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		3 / 3 LYS A 209
ARG A  49
VAL A  48
 None
EDO  A 266 (-4.5A)
K  A 262 ( 4.3A)
 0.95A 4x3uA-3qxzA:
undetectable
4x3uB-3qxzA:
undetectable		 4x3uA-3qxzA:
13.10
4x3uB-3qxzA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		4 / 8 ILE A 108
GLY A  32
THR A  28
LEU A   5
 EDO  A 264 (-4.7A)
None
None
None
 0.98A 5hwaA-3qxzA:
undetectable		 5hwaA-3qxzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		4 / 5 THR A 111
HIS A 115
ALA A 142
ASP A 139
 None
None
None
EDO  A 264 (-4.1A)
 1.04A 5mfxA-3qxzA:
undetectable		 5mfxA-3qxzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 12 ALA A  59
PRO A  21
SER A  26
ALA A 105
ARG A 126
 None
None
None
None
GOL  A 269 ( 4.8A)
 1.36A 5zvgA-3qxzA:
undetectable		 5zvgA-3qxzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3qxz ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 12 ALA A  59
PRO A  21
SER A  26
ALA A 105
ARG A 126
 None
None
None
None
GOL  A 269 ( 4.8A)
 1.35A 5zvgB-3qxzA:
undetectable		 5zvgB-3qxzA:
22.25