SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3qyb TBC1 DOMAIN FAMILY
MEMBER 4
(Homo
sapiens) 		4 / 6 LEU A 956
PHE A1029
LEU A 995
ASP A1003
 None
 0.94A 2wm3A-3qybA:
undetectable		 2wm3A-3qybA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3qyb TBC1 DOMAIN FAMILY
MEMBER 4
(Homo
sapiens) 		4 / 8 ILE A1108
ILE A1109
VAL A1164
ILE A1117
 None
 0.65A 3p4wC-3qybA:
undetectable		 3p4wC-3qybA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 3qyb TBC1 DOMAIN FAMILY
MEMBER 4
(Homo
sapiens) 		5 / 7 PHE A1093
PHE A1097
ALA A1085
LEU A1125
LEU A1149
 None
 1.41A 4ejgC-3qybA:
undetectable		 4ejgC-3qybA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3qyb TBC1 DOMAIN FAMILY
MEMBER 4
(Homo
sapiens) 		5 / 10 VAL A1116
VAL A1164
ILE A1161
LEU A 932
LEU A 916
 None
 1.46A 4jtqA-3qybA:
undetectable		 4jtqA-3qybA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3qyb TBC1 DOMAIN FAMILY
MEMBER 4
(Homo
sapiens) 		4 / 5 PHE A 975
HIS A1022
PHE A 981
LEU A 878
 None
 1.40A 4o8zA-3qybA:
undetectable		 4o8zA-3qybA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3qyb TBC1 DOMAIN FAMILY
MEMBER 4
(Homo
sapiens) 		4 / 6 HIS A1073
LEU A1070
CYH A1135
LEU A1145
 None
 1.05A 5hrqD-3qybA:
undetectable
5hrqG-3qybA:
undetectable
5hrqH-3qybA:
undetectable		 5hrqD-3qybA:
6.51
5hrqG-3qybA:
5.56
5hrqH-3qybA:
6.51