SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 8 MET A 777
LEU A 992
VAL A 801
GLY A 800
 None
 1.01A 1hrkA-3qyeA:
undetectable		 1hrkA-3qyeA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 8 MET A 777
LEU A 992
VAL A 801
GLY A 800
 None
 1.02A 1hrkB-3qyeA:
undetectable		 1hrkB-3qyeA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 6 TYR A 874
SER A 881
ALA A 879
THR A 842
 None
 1.09A 1yvpB-3qyeA:
undetectable		 1yvpB-3qyeA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 6 LEU A 922
TYR A 926
ILE A 998
GLY A 892
 None
 0.94A 2du8B-3qyeA:
undetectable		 2du8B-3qyeA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 11 HIS A 794
LEU A 992
ASN A1043
ILE A 809
ILE A1042
 None
 1.16A 2uxoB-3qyeA:
undetectable		 2uxoB-3qyeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 8 TYR A 947
LEU A 944
LEU A1003
MET A1048
 None
 1.04A 2wekA-3qyeA:
undetectable		 2wekA-3qyeA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 TYR A 889
GLY A 898
ALA A 897
LEU A 913
LEU A 916
 None
 0.97A 3n8yB-3qyeA:
undetectable		 3n8yB-3qyeA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 5 PHE A 856
HIS A 903
PHE A 862
LEU A 758
 None
 1.42A 4o8zA-3qyeA:
undetectable		 4o8zA-3qyeA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A1033
PHE A 978
TRP A 969
ILE A1022
LEU A 955
 None
 1.24A 5ienA-3qyeA:
undetectable		 5ienA-3qyeA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 9 VAL A1045
LEU A1030
GLY A1007
LEU A1006
THR A1041
 None
 1.35A 6czmB-3qyeA:
undetectable
6czmC-3qyeA:
undetectable		 6czmB-3qyeA:
23.33
6czmC-3qyeA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A1050
THR A1041
ILE A1042
PHE A 974
MET A 973
 None
 1.33A 6j20A-3qyeA:
undetectable		 6j20A-3qyeA:
19.61