SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 9 LEU A  73
LEU A 122
VAL A 108
GLY A 106
ALA A 105
 None
 1.16A 1pxxB-3qyfA:
undetectable		 1pxxB-3qyfA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 10 LEU A  73
LEU A 122
VAL A 108
GLY A 106
ALA A 105
 None
 1.16A 1pxxD-3qyfA:
undetectable		 1pxxD-3qyfA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 GLY A 166
LEU A  37
ASP A  35
ASP A  41
PHE A  39
 None
 1.37A 2b9eA-3qyfA:
3.9		 2b9eA-3qyfA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 ARG A  67
GLU A 115
SER A  75
 None
 0.95A 2xkkA-3qyfA:
3.0
2xkkC-3qyfA:
1.7		 2xkkA-3qyfA:
17.78
2xkkC-3qyfA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 10 LEU A 113
SER A 120
ILE A 109
SER A  96
GLY A 106
 None
 1.23A 3ijxB-3qyfA:
1.2
3ijxD-3qyfA:
undetectable		 3ijxB-3qyfA:
20.43
3ijxD-3qyfA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 10 ILE A 109
SER A  96
GLY A 106
LEU A 113
SER A 120
 None
 1.38A 3ik6B-3qyfA:
undetectable
3ik6E-3qyfA:
undetectable		 3ik6B-3qyfA:
20.43
3ik6E-3qyfA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 GLU A  72
ASN A 162
ILE A 118
SER A  70
GLN A 191
 None
 1.32A 4djfA-3qyfA:
undetectable		 4djfA-3qyfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 GLY A   9
GLY A 166
ALA A  71
ALA A 105
ASP A  35
 None
 1.22A 4kicA-3qyfA:
3.2		 4kicA-3qyfA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A  37
LEU A  31
SER A  16
LEU A 104
ILE A  47
 None
 1.14A 4x1fA-3qyfA:
undetectable		 4x1fA-3qyfA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A  37
LEU A  31
SER A  16
LEU A 104
ILE A  47
 None
 1.12A 4x1gA-3qyfA:
undetectable		 4x1gA-3qyfA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 ASP A  74
ARG A  67
ASP A 195
 None
None
MG  A 322 (-2.2A)
 0.80A 5zvgA-3qyfA:
3.0		 5zvgA-3qyfA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 ASP A  74
ARG A  67
ASP A 195
 None
None
MG  A 322 (-2.2A)
 0.82A 5zvgB-3qyfA:
2.4		 5zvgB-3qyfA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3qyf CRISPR-ASSOCIATED
PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 PHE A  93
HIS A   4
VAL A 159
SER A 120
 None
 1.06A 6hu9S-3qyfA:
undetectable
6hu9q-3qyfA:
undetectable		 6hu9S-3qyfA:
14.56
6hu9q-3qyfA:
20.00