SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ILE A  59
GLY A  48
VAL A  75
ASP A 104
GLY A  72
 None
 0.96A 1kiaB-3qyqA:
undetectable		 1kiaB-3qyqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ILE A  59
GLY A  48
VAL A  75
ASP A 104
GLY A  72
 None
 0.96A 1kiaC-3qyqA:
undetectable		 1kiaC-3qyqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ILE A  59
GLY A  48
VAL A  75
ASP A 104
GLY A  72
 None
 1.10A 1nbiA-3qyqA:
undetectable		 1nbiA-3qyqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ILE A  59
GLY A  48
VAL A  75
ASP A 104
GLY A  72
 None
 1.09A 1nbiB-3qyqA:
undetectable		 1nbiB-3qyqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ILE A 157
ALA A 160
ALA A 161
LEU A 172
HIS A 189
 None
 0.98A 1xiuB-3qyqA:
undetectable		 1xiuB-3qyqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 11 ARG A  13
ALA A 236
ASP A 237
ILE A 251
PHE A  10
 None
 1.10A 2fxdA-3qyqA:
undetectable		 2fxdA-3qyqA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		4 / 5 LEU A 190
ALA A 161
LEU A 172
MET A 242
 None
 1.08A 2oaxA-3qyqA:
undetectable		 2oaxA-3qyqA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 12 VAL A 137
SER A  50
VAL A  56
GLY A 102
ALA A  98
 None
 1.13A 2x2iA-3qyqA:
5.4		 2x2iA-3qyqA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 12 VAL A 137
SER A  50
VAL A  56
GLY A 102
ALA A  98
 None
 1.19A 2x2iC-3qyqA:
6.0		 2x2iC-3qyqA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		4 / 7 GLU A 105
ARG A 257
GLU A  20
SER A  50
 None
 1.16A 2zt7A-3qyqA:
undetectable		 2zt7A-3qyqA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ALA A  22
GLY A 260
LEU A 178
ARG A  52
SER A  50
 None
 1.32A 3bxoA-3qyqA:
undetectable		 3bxoA-3qyqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ARG A  13
LEU A  16
ALA A  40
GLY A  72
ILE A  46
 None
 1.07A 3mwsA-3qyqA:
undetectable		 3mwsA-3qyqA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		4 / 6 ALA A  95
GLY A 138
PRO A 139
LEU A  99
 None
 0.89A 4dubB-3qyqA:
undetectable		 4dubB-3qyqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		4 / 6 PHE A 256
ILE A 243
PRO A 248
PHE A  18
 None
None
SO4  A 287 (-3.6A)
None
 1.26A 4fgkA-3qyqA:
undetectable		 4fgkA-3qyqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		3 / 3 THR A  11
THR A  14
PHE A  19
 None
 0.62A 5cxvA-3qyqA:
undetectable		 5cxvA-3qyqA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ILE A 157
ALA A 160
ALA A 161
LEU A 172
HIS A 189
 None
 1.00A 6a60D-3qyqA:
undetectable		 6a60D-3qyqA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE
(Toxoplasma
gondii) 		3 / 3 GLY A  86
THR A  90
GLU A  94
 None
 0.65A 6b58A-3qyqA:
undetectable		 6b58A-3qyqA:
19.93