SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A  39
TYR A 243
GLY A 308
ASP A 163
ALA A 101
 EPE  A 338 (-2.7A)
None
None
EPE  A 338 ( 4.6A)
UNX  A 334 ( 4.8A)
 0.93A 1e3vA-3qz4A:
undetectable		 1e3vA-3qz4A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A  39
TYR A 243
GLY A 308
ASP A 163
ALA A 101
 EPE  A 338 (-2.7A)
None
None
EPE  A 338 ( 4.6A)
UNX  A 334 ( 4.8A)
 0.95A 1e3vB-3qz4A:
undetectable		 1e3vB-3qz4A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 219
VAL A 164
TRP A 179
 UNX  A 334 ( 4.9A)
None
None
 0.55A 1gmkA-3qz4A:
undetectable
1gmkB-3qz4A:
undetectable		 1gmkA-3qz4A:
10.34
1gmkB-3qz4A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 219
VAL A 164
TRP A 179
 UNX  A 334 ( 4.9A)
None
None
 0.63A 1gmkC-3qz4A:
undetectable
1gmkD-3qz4A:
undetectable		 1gmkC-3qz4A:
10.34
1gmkD-3qz4A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 4 THR A 152
GLY A 147
ASP A 145
ALA A  95
 None
 1.19A 1sg9A-3qz4A:
undetectable		 1sg9A-3qz4A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		6 / 12 SER A 154
PRO A 155
GLY A 182
SER A 153
ILE A 151
GLY A 180
 None
EDO  A 339 (-3.6A)
None
EDO  A 339 (-4.2A)
EDO  A 339 ( 4.7A)
None
 1.32A 1uakA-3qz4A:
undetectable		 1uakA-3qz4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 229
VAL A 222
TYR A 178
ASP A 169
 None
 1.21A 2x45A-3qz4A:
undetectable		 2x45A-3qz4A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 229
VAL A 222
TYR A 178
ASP A 169
 None
 1.19A 2x45B-3qz4A:
undetectable		 2x45B-3qz4A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 229
VAL A 222
TYR A 178
ASP A 169
 None
 1.21A 2x45C-3qz4A:
undetectable		 2x45C-3qz4A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 229
VAL A 222
TYR A 178
ASP A 169
 None
 1.21A 3bu1A-3qz4A:
undetectable		 3bu1A-3qz4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 4 PRO A 206
TYR A 214
GLY A 248
THR A 249
 None
 1.38A 3ib0A-3qz4A:
undetectable		 3ib0A-3qz4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A  86
PHE A 143
PRO A 142
ALA A 136
 None
 1.18A 3vm4A-3qz4A:
undetectable		 3vm4A-3qz4A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 109
VAL A 135
LEU A 146
ASP A 192
 None
 1.18A 3wzdA-3qz4A:
undetectable		 3wzdA-3qz4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 163
ASP A  39
GLU A 218
ASP A  58
 EPE  A 338 ( 4.6A)
EPE  A 338 (-2.7A)
EPE  A 338 ( 3.6A)
None
 1.12A 4gkhC-3qz4A:
undetectable
4gkhK-3qz4A:
undetectable		 4gkhC-3qz4A:
20.06
4gkhK-3qz4A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 163
ASP A  39
GLU A 218
ASP A  58
 EPE  A 338 ( 4.6A)
EPE  A 338 (-2.7A)
EPE  A 338 ( 3.6A)
None
 1.08A 4gkiE-3qz4A:
undetectable
4gkiG-3qz4A:
undetectable		 4gkiE-3qz4A:
20.06
4gkiG-3qz4A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 189
MET A 193
ASP A 163
 None
None
EPE  A 338 ( 4.6A)
 0.81A 4j7xB-3qz4A:
undetectable		 4j7xB-3qz4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 196
LEU A 189
GLY A 132
ILE A 131
ASN A  98
 None
 1.13A 4o1eA-3qz4A:
undetectable		 4o1eA-3qz4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 196
LEU A 189
GLY A 132
ILE A 131
ASN A  98
 None
 1.14A 4o1eB-3qz4A:
undetectable		 4o1eB-3qz4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 298
PHE A  60
SER A 240
ASP A  39
 None
None
None
EPE  A 338 (-2.7A)
 1.43A 4rzvB-3qz4A:
undetectable		 4rzvB-3qz4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 303
ARG A 297
PRO A 331
ASN A 269
ILE A 274
 None
 1.25A 5uhbC-3qz4A:
1.5		 5uhbC-3qz4A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 303
ARG A 297
PRO A 331
ASN A 269
ILE A 274
 None
 1.31A 5uhcC-3qz4A:
1.6		 5uhcC-3qz4A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 303
ARG A 297
PRO A 331
ASN A 269
ILE A 274
 None
 1.29A 5uhdC-3qz4A:
1.0		 5uhdC-3qz4A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3qz4 ENDO-1,4-BETA-XYLANA
SE D
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 303
ARG A 297
PRO A 331
ASN A 269
ILE A 274
 None
 1.26A 5uhgC-3qz4A:
1.1		 5uhgC-3qz4A:
14.27