SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qz5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 3qz5 CO-TYPE NITRILE
HYDRATASE ALPHA
SUBUNIT
(Pseudomonas
putida) 		4 / 5 ALA A 132
TYR A 135
ALA A 128
TYR A 130
 GOL  A 212 ( 3.8A)
None
None
None
 0.95A 1xl6A-3qz5A:
undetectable
1xl6B-3qz5A:
undetectable		 1xl6A-3qz5A:
23.29
1xl6B-3qz5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3qz5 CO-TYPE NITRILE
HYDRATASE ALPHA
SUBUNIT
(Pseudomonas
putida) 		5 / 12 GLY A 200
GLY A 202
ASN A 108
ASP A 164
PRO A 143
 None
 1.05A 2dpmA-3qz5A:
undetectable		 2dpmA-3qz5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 3qz5 CO-TYPE NITRILE
HYDRATASE ALPHA
SUBUNIT
(Pseudomonas
putida) 		4 / 4 ALA A 132
TYR A 135
ALA A 128
TYR A 130
 GOL  A 212 ( 3.8A)
None
None
None
 0.95A 2wlkA-3qz5A:
undetectable
2wlkB-3qz5A:
undetectable		 2wlkA-3qz5A:
23.29
2wlkB-3qz5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 3qz5 CO-TYPE NITRILE
HYDRATASE ALPHA
SUBUNIT
(Pseudomonas
putida) 		4 / 6 LEU A 147
ILE A 154
ASN A 102
VAL A 173
 None
 0.89A 4a9kA-3qz5A:
undetectable		 4a9kA-3qz5A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3qz5 CO-TYPE NITRILE
HYDRATASE ALPHA
SUBUNIT
(Pseudomonas
putida) 		5 / 11 ARG A 138
GLY A  13
ASP A  12
ALA A 132
PRO A 127
 None
GOL  A 212 ( 3.9A)
None
GOL  A 212 ( 3.8A)
None
 1.08A 5yk2A-3qz5A:
undetectable		 5yk2A-3qz5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3qz5 CO-TYPE NITRILE
HYDRATASE ALPHA
SUBUNIT
(Pseudomonas
putida) 		5 / 11 GLY A  13
ASP A  12
ALA A 132
ALA A 128
PRO A 127
 GOL  A 212 ( 3.9A)
None
GOL  A 212 ( 3.8A)
None
None
 1.15A 5yk2A-3qz5A:
undetectable		 5yk2A-3qz5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3qz5 CO-TYPE NITRILE
HYDRATASE ALPHA
SUBUNIT
(Pseudomonas
putida) 		3 / 3 TYR A 130
PRO A 119
LEU A 123
 None
 0.84A 6beoA-3qz5A:
undetectable		 6beoA-3qz5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3qz5 CO-TYPE NITRILE
HYDRATASE ALPHA
SUBUNIT
(Pseudomonas
putida) 		5 / 11 ASN A 102
VAL A  98
THR A 165
ILE A 160
VAL A 109
 None
 1.49A 6hcoA-3qz5A:
undetectable
6hcoB-3qz5A:
undetectable		 6hcoA-3qz5A:
15.02
6hcoB-3qz5A:
15.02