SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		6 / 12 THR A  99
THR A 103
VAL A 165
ILE A 156
GLY A  93
ILE A 147
 None
 1.36A 1bx4A-3qz6A:
undetectable		 1bx4A-3qz6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		4 / 5 SER A  65
PHE A 142
GLU A  87
GLY A  88
 None
 1.32A 1icrA-3qz6A:
undetectable
1icrB-3qz6A:
undetectable		 1icrA-3qz6A:
23.11
1icrB-3qz6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		4 / 5 GLU A  87
GLY A  88
SER A  65
PHE A 142
 None
 1.33A 1icrA-3qz6A:
undetectable
1icrB-3qz6A:
undetectable		 1icrA-3qz6A:
23.11
1icrB-3qz6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		4 / 4 SER A  65
PHE A 142
GLU A  87
GLY A  88
 None
 1.30A 1icvA-3qz6A:
undetectable
1icvB-3qz6A:
undetectable		 1icvA-3qz6A:
23.11
1icvB-3qz6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		4 / 5 GLU A  87
GLY A  88
SER A  65
PHE A 142
 None
 1.30A 1kqbA-3qz6A:
undetectable
1kqbB-3qz6A:
undetectable		 1kqbA-3qz6A:
23.90
1kqbB-3qz6A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		4 / 8 TYR A  30
THR A  16
THR A 241
ASP A 235
 None
 1.13A 1uyuA-3qz6A:
undetectable		 1uyuA-3qz6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		4 / 8 TYR A  30
THR A  16
THR A 241
ASP A 235
 None
 1.11A 1uyuB-3qz6A:
undetectable		 1uyuB-3qz6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 239
ALA A 238
TRP A 232
LEU A  18
LEU A  35
 None
 1.31A 2oaxD-3qz6A:
undetectable		 2oaxD-3qz6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 239
ALA A 238
TRP A 232
LEU A  18
LEU A  35
 None
 1.23A 2oaxF-3qz6A:
undetectable		 2oaxF-3qz6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 GLY A 234
ALA A 214
ALA A 213
LEU A  18
PHE A  38
 None
 1.06A 3p2kA-3qz6A:
undetectable		 3p2kA-3qz6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		3 / 3 LYS A   0
ARG A 137
TRP A 133
 None
 1.44A 4i90A-3qz6A:
2.3		 4i90A-3qz6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		4 / 6 TYR A 191
TYR A 194
TRP A 221
PHE A 211
 None
 1.30A 5e2iA-3qz6A:
undetectable		 5e2iA-3qz6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3qz6 HPCH/HPAI ALDOLASE
(Desulfitobacteri
um
hafniense) 		4 / 6 CYH A 193
LEU A 179
HIS A 149
LEU A 175
 None
 1.18A 5hpuC-3qz6A:
undetectable
5hpuD-3qz6A:
undetectable		 5hpuC-3qz6A:
10.26
5hpuD-3qz6A:
8.87