SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXT_A_MTXA2000_1 (ANTI-METHOTREXATE CDR1-3 GRAFT VHH)	3r0m	LLAMA VHH A12 (Lama glama)	5 / 12	ALA A 24 SER A 29 MET A 34 VAL A 78 ALA A 94	None SO4 A 131 (-2.7A) None None None	0.83A	3qxtA-3r0mA: 21.2	3qxtA-3r0mA: 70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXT_B_MTXB2000_1 (ANTI-METHOTREXATE CDR1-3 GRAFT VHH)	3r0m	LLAMA VHH A12 (Lama glama)	6 / 12	LEU A 4 ALA A 24 SER A 29 MET A 34 VAL A 78 ALA A 94	None None SO4 A 131 (-2.7A) None None None	0.83A	3qxtB-3r0mA: 21.3	3qxtB-3r0mA: 70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_B_MTXB2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	3r0m	LLAMA VHH A12 (Lama glama)	5 / 12	ALA A 24 SER A 29 MET A 34 VAL A 78 ALA A 94	None SO4 A 131 (-2.7A) None None None	0.93A	3qxvB-3r0mA: 21.4	3qxvB-3r0mA: 70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_C_MTXC2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	3r0m	LLAMA VHH A12 (Lama glama)	6 / 11	ALA A 24 SER A 29 MET A 34 ASN A 73 VAL A 78 ALA A 94	None SO4 A 131 (-2.7A) None None None None	1.12A	3qxvC-3r0mA: 21.2	3qxvC-3r0mA: 70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_D_MTXD2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	3r0m	LLAMA VHH A12 (Lama glama)	5 / 12	ALA A 24 SER A 29 MET A 34 VAL A 78 ALA A 94	None SO4 A 131 (-2.7A) None None None	0.94A	3qxvD-3r0mA: 21.2	3qxvD-3r0mA: 70.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECM_D_LEUD602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	3r0m	LLAMA VHH A12 (Lama glama)	4 / 7	ALA A 88 THR A 87 VAL A 109 GLU A 85	None	0.74A	5ecmD-3r0mA: undetectable	5ecmD-3r0mA: 12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECO_D_LEUD602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	3r0m	LLAMA VHH A12 (Lama glama)	4 / 7	ALA A 88 THR A 87 VAL A 109 GLU A 85	None	0.82A	5ecoD-3r0mA: undetectable	5ecoD-3r0mA: 12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_C_CVIC301_1 (REGULATORY PROTEIN TETR)	3r0m	LLAMA VHH A12 (Lama glama)	4 / 7	GLY A 35 GLN A 3 ASP A 102 TYR A 101	None	1.11A	5vlmC-3r0mA: undetectable	5vlmC-3r0mA: 26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_G_CVIG301_1 (REGULATORY PROTEIN TETR)	3r0m	LLAMA VHH A12 (Lama glama)	4 / 7	GLY A 35 GLN A 3 ASP A 102 TYR A 101	None	1.00A	5vlmG-3r0mA: undetectable	5vlmG-3r0mA: 26.23

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3QXT_A_MTXA2000_1","ANTI-METHOTREXATE CDR1-3 GRAFT VHH","3r0m","LLAMA VHH A12","Lama glama",5,"ALA A  24;SER A  29;MET A  34;VAL A  78;ALA A  94","None;SO4 A 131 (-2.7A);None;None;None","0.83A","3qxtA-3r0mA:21.2","3qxtA-3r0mA:70.54"],["3QXT_B_MTXB2000_1","ANTI-METHOTREXATE CDR1-3 GRAFT VHH","3r0m","LLAMA VHH A12","Lama glama",6,"LEU A   4;ALA A  24;SER A  29;MET A  34;VAL A  78;ALA A  94","None;None;SO4 A 131 (-2.7A);None;None;None","0.83A","3qxtB-3r0mA:21.3","3qxtB-3r0mA:70.54"],["3QXV_B_MTXB2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","3r0m","LLAMA VHH A12","Lama glama",5,"ALA A  24;SER A  29;MET A  34;VAL A  78;ALA A  94","None;SO4 A 131 (-2.7A);None;None;None","0.93A","3qxvB-3r0mA:21.4","3qxvB-3r0mA:70.54"],["3QXV_C_MTXC2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","3r0m","LLAMA VHH A12","Lama glama",6,"ALA A  24;SER A  29;MET A  34;ASN A  73;VAL A  78;ALA A  94","None;SO4 A 131 (-2.7A);None;None;None;None","1.12A","3qxvC-3r0mA:21.2","3qxvC-3r0mA:70.54"],["3QXV_D_MTXD2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","3r0m","LLAMA VHH A12","Lama glama",5,"ALA A  24;SER A  29;MET A  34;VAL A  78;ALA A  94","None;SO4 A 131 (-2.7A);None;None;None","0.94A","3qxvD-3r0mA:21.2","3qxvD-3r0mA:70.54"],["5ECM_D_LEUD602_0","JASMONIC ACID-AMIDO SYNTHETASE JAR1","3r0m","LLAMA VHH A12","Lama glama",4,"ALA A  88;THR A  87;VAL A 109;GLU A  85","None","0.74A","5ecmD-3r0mA:undetectable","5ecmD-3r0mA:12.92"],["5ECO_D_LEUD602_0","JASMONIC ACID-AMIDO SYNTHETASE JAR1","3r0m","LLAMA VHH A12","Lama glama",4,"ALA A  88;THR A  87;VAL A 109;GLU A  85","None","0.82A","5ecoD-3r0mA:undetectable","5ecoD-3r0mA:12.92"],["5VLM_C_CVIC301_1","REGULATORY PROTEIN TETR","3r0m","LLAMA VHH A12","Lama glama",4,"GLY A  35;GLN A   3;ASP A 102;TYR A 101","None","1.11A","5vlmC-3r0mA:undetectable","5vlmC-3r0mA:26.23"],["5VLM_G_CVIG301_1","REGULATORY PROTEIN TETR","3r0m","LLAMA VHH A12","Lama glama",4,"GLY A  35;GLN A   3;ASP A 102;TYR A 101","None","1.00A","5vlmG-3r0mA:undetectable","5vlmG-3r0mA:26.23"]]