SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 12 GLY A 137
ILE A  24
GLY A  63
SER A  68
ILE A  26
 None
 0.91A 1q8jB-3r0oA:
undetectable		 1q8jB-3r0oA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 8 ALA A 124
LEU A 123
GLY A 151
GLY A 116
 EDO  A 270 (-4.1A)
None
None
None
 0.81A 1rukH-3r0oA:
undetectable
1rukL-3r0oA:
undetectable		 1rukH-3r0oA:
22.70
1rukL-3r0oA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		6 / 12 ILE A  24
LEU A  23
GLY A  63
SER A  68
ASN A 111
ILE A  26
 None
 1.49A 2e7fB-3r0oA:
undetectable		 2e7fB-3r0oA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 12 GLY A 118
GLY A  63
SER A  68
ASN A 111
ILE A  26
 None
 1.21A 3k13A-3r0oA:
undetectable		 3k13A-3r0oA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 12 GLY A 118
GLY A  63
SER A  68
ASN A 111
ILE A  26
 None
 1.21A 3k13B-3r0oA:
undetectable		 3k13B-3r0oA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 12 GLY A 118
GLY A  63
SER A  68
ASN A 111
ILE A  26
 None
 1.21A 3k13C-3r0oA:
undetectable		 3k13C-3r0oA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 12 HIS A  99
ALA A 124
LEU A 123
LEU A 138
ILE A 102
 None
EDO  A 270 (-4.1A)
None
None
EDO  A 270 ( 4.3A)
 0.99A 3ozwB-3r0oA:
undetectable		 3ozwB-3r0oA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 6 ALA A  73
ILE A  78
LEU A  84
GLU A 120
ALA A 149
 None
 0.63A 3r9sC-3r0oA:
43.1		 3r9sC-3r0oA:
75.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 6 ALA A  73
LEU A  84
GLU A 120
GLU A 140
ALA A 149
 None
 0.55A 3r9sC-3r0oA:
43.1		 3r9sC-3r0oA:
75.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9T_A_BEZA264_0
(ECHA1_1)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 8 ALA A  73
GLU A 120
GLU A 140
ALA A 149
 None
 0.56A 3r9tA-3r0oA:
43.1		 3r9tA-3r0oA:
75.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9T_C_BEZC264_0
(ECHA1_1)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 5 ALA A  73
GLU A 120
GLU A 140
ALA A 149
 None
 0.52A 3r9tC-3r0oA:
43.3		 3r9tC-3r0oA:
75.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 5 LEU A 123
LEU A 138
GLY A 137
GLY A 116
 None
 0.77A 3si7C-3r0oA:
undetectable
3si7D-3r0oA:
undetectable		 3si7C-3r0oA:
23.64
3si7D-3r0oA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 5 HIS A  89
THR A  41
GLU A  48
ASP A 103
 None
 1.40A 3tm4A-3r0oA:
undetectable		 3tm4A-3r0oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 5 HIS A  89
THR A  41
GLU A  48
ASP A 103
 None
 1.41A 3tm4B-3r0oA:
undetectable		 3tm4B-3r0oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 5 LEU A 159
ALA A 179
PHE A 136
ASN A 186
 None
 1.34A 3uq6A-3r0oA:
undetectable		 3uq6A-3r0oA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 8 VAL A  60
ILE A  61
TYR A  97
PHE A  69
 None
None
EDO  A 270 (-3.6A)
None
 0.68A 3uqbA-3r0oA:
undetectable		 3uqbA-3r0oA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 4 LEU A 159
ALA A 179
PHE A 136
ASN A 186
 None
 1.40A 3vaqA-3r0oA:
undetectable		 3vaqA-3r0oA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 4 LEU A 159
ALA A 179
PHE A 136
ASN A 186
 None
 1.36A 3vasA-3r0oA:
3.2		 3vasA-3r0oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 12 ILE A  24
GLY A  63
SER A  68
ASN A 111
ILE A  26
 None
 1.25A 4djfA-3r0oA:
undetectable		 4djfA-3r0oA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 7 ALA A 130
PHE A 136
ALA A 114
ALA A 108
 None
 0.77A 4du2A-3r0oA:
undetectable		 4du2A-3r0oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 7 ALA A 130
PHE A 136
ALA A 114
ALA A 108
 None
 0.79A 4du2B-3r0oA:
undetectable		 4du2B-3r0oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 10 ALA A 176
THR A 175
ALA A 179
VAL A 188
GLY A 112
 None
 1.00A 4qvyK-3r0oA:
undetectable
4qvyL-3r0oA:
undetectable		 4qvyK-3r0oA:
24.03
4qvyL-3r0oA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 10 ALA A 176
THR A 175
ALA A 179
VAL A 188
GLY A 112
 None
 1.00A 4qvyY-3r0oA:
undetectable
4qvyZ-3r0oA:
undetectable		 4qvyY-3r0oA:
24.03
4qvyZ-3r0oA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 9 ALA A 108
ILE A 205
ALA A 198
ILE A  61
VAL A  21
 None
 1.10A 4r21B-3r0oA:
undetectable		 4r21B-3r0oA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 12 GLY A 112
ALA A 134
SER A 133
ILE A  26
ASP A  66
 None
 1.19A 4rtpA-3r0oA:
undetectable		 4rtpA-3r0oA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		4 / 7 ALA A  71
SER A  68
ILE A  26
LEU A 121
 None
 0.79A 4uymA-3r0oA:
undetectable		 4uymA-3r0oA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 10 GLY A 117
GLY A 116
GLN A 158
LEU A 121
ALA A 124
 None
None
None
None
EDO  A 270 (-4.1A)
 1.04A 5l0zB-3r0oA:
undetectable		 5l0zB-3r0oA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 11 ALA A 122
ALA A 124
VAL A 110
GLY A 116
GLY A 117
 None
EDO  A 270 (-4.1A)
None
None
None
 0.95A 5lf7K-3r0oA:
undetectable
5lf7L-3r0oA:
undetectable		 5lf7K-3r0oA:
24.82
5lf7L-3r0oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 11 ALA A 122
ALA A 124
VAL A 110
GLY A 116
GLY A 117
 None
EDO  A 270 (-4.1A)
None
None
None
 0.96A 5lf7Y-3r0oA:
undetectable
5lf7Z-3r0oA:
undetectable		 5lf7Y-3r0oA:
24.82
5lf7Z-3r0oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 12 GLU A 187
VAL A 188
LEU A 123
ALA A 179
GLY A 112
 None
 1.22A 5syeB-3r0oA:
undetectable		 5syeB-3r0oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		5 / 12 ALA A 114
GLY A 118
SER A 119
LEU A 138
PHE A  94
 None
 1.50A 5vlmF-3r0oA:
undetectable		 5vlmF-3r0oA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3r0o CARNITINYL-COA
DEHYDRATASE
(Mycobacterium
avium) 		6 / 12 GLY A 118
LEU A  23
GLY A  63
SER A  68
ASN A 111
ILE A  26
 None
 1.45A 5vopB-3r0oA:
undetectable		 5vopB-3r0oA:
24.05