SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		4 / 8 ALA A 102
LEU A  99
GLY A  96
GLY A  90
 None
 0.81A 1rukH-3r0vA:
undetectable
1rukL-3r0vA:
undetectable		 1rukH-3r0vA:
21.38
1rukL-3r0vA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 LEU A 100
ILE A 108
VAL A  88
ALA A  77
VAL A  26
 None
 1.07A 2g72B-3r0vA:
2.7		 2g72B-3r0vA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		4 / 6 PHE A 114
TYR A 234
ARG A 219
GLY A 211
 None
 1.16A 2i30A-3r0vA:
undetectable		 2i30A-3r0vA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		5 / 11 LEU A 111
VAL A  24
ILE A  78
ILE A  72
VAL A  88
 None
 1.08A 2nnpB-3r0vA:
undetectable		 2nnpB-3r0vA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 LEU A 106
GLY A  84
ALA A  85
ILE A  50
SER A  98
 None
None
None
OCS  A  51 ( 3.6A)
None
 0.99A 3ogqB-3r0vA:
undetectable		 3ogqB-3r0vA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		4 / 7 PRO A  22
LEU A  75
GLY A  84
ALA A  82
 None
 0.94A 3tehB-3r0vA:
undetectable		 3tehB-3r0vA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		4 / 6 PHE A 199
ARG A 198
GLU A  69
VAL A  68
 None
 1.03A 5h4dA-3r0vA:
2.8		 5h4dA-3r0vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 GLY A  96
ILE A 229
ALA A 102
ALA A 103
ILE A 202
 None
 0.91A 5kb6B-3r0vA:
4.5		 5kb6B-3r0vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		3 / 3 GLU A 224
HIS A 220
VAL A 120
 None
 0.81A 5trqB-3r0vA:
undetectable		 5trqB-3r0vA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		5 / 10 VAL A  49
VAL A  23
LEU A  39
ALA A 250
PRO A 246
 OCS  A  51 ( 4.4A)
None
None
None
None
 1.30A 5tt3A-3r0vA:
undetectable		 5tt3A-3r0vA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		5 / 10 VAL A  49
VAL A  23
LEU A  39
ALA A 250
PRO A 246
 OCS  A  51 ( 4.4A)
None
None
None
None
 1.33A 5tt3C-3r0vA:
undetectable		 5tt3C-3r0vA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		4 / 8 LEU A  97
ARG A  54
LEU A 106
ILE A  78
 None
 0.91A 5v0vA-3r0vA:
undetectable		 5v0vA-3r0vA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		4 / 7 PHE A 114
ILE A 249
LEU A 207
PHE A  89
 None
 0.80A 5x5qC-3r0vA:
undetectable		 5x5qC-3r0vA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		4 / 8 PHE A 114
ILE A 249
LEU A 207
PHE A  89
 None
 0.82A 5x5qD-3r0vA:
undetectable		 5x5qD-3r0vA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		4 / 8 PHE A 114
ILE A 249
LEU A 207
PHE A  89
 None
 0.82A 5x5qF-3r0vA:
undetectable		 5x5qF-3r0vA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		3 / 3 TYR A  66
ARG A  55
THR A 181
 None
 0.77A 5z84J-3r0vA:
undetectable		 5z84J-3r0vA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Sphaerobacter
thermophilus) 		4 / 7 VAL A 188
PHE A  89
MET A 209
LEU A 111
 None
 1.10A 6aycA-3r0vA:
undetectable		 6aycA-3r0vA:
16.52