SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 7 PHE A  57
PHE A 156
PHE A 182
HIS A 127
 None
 0.92A 1lh6A-3r0zA:
undetectable		 1lh6A-3r0zA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 ALA A 286
ALA A 247
GLY A 283
MET A 351
LEU A 242
 None
 1.23A 1qabF-3r0zA:
undetectable		 1qabF-3r0zA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 6 ASP A  16
LEU A  17
VAL A  18
ILE A 327
 None
 0.88A 1s9qA-3r0zA:
undetectable		 1s9qA-3r0zA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 5 CYH A 309
TYR A 315
THR A  23
THR A 360
 None
 1.36A 1ymxB-3r0zA:
undetectable		 1ymxB-3r0zA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 7 GLY A 423
THR A 422
TRP A 420
SER A  77
 None
 1.12A 2o5yH-3r0zA:
undetectable
2o5yL-3r0zA:
undetectable		 2o5yH-3r0zA:
18.90
2o5yL-3r0zA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 LEU A  20
GLY A 328
GLY A 341
PRO A 304
THR A 305
 None
 0.80A 3gguA-3r0zA:
undetectable		 3gguA-3r0zA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		3 / 3 ASP A 356
PHE A 271
SER A 398
 None
 0.79A 3i5uB-3r0zA:
2.6		 3i5uB-3r0zA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 6 PHE A 407
ASP A 356
TYR A 401
PRO A 269
 None
 1.29A 3jqaA-3r0zA:
2.6		 3jqaA-3r0zA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 6 PHE A 407
ASP A 356
TYR A 401
PRO A 269
 None
 1.35A 3jqaB-3r0zA:
2.8		 3jqaB-3r0zA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 6 PHE A 407
ASP A 356
TYR A 401
PRO A 269
 None
 1.26A 3jqaC-3r0zA:
2.3		 3jqaC-3r0zA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 7 GLY A 204
CYH A 231
PHE A 232
GLY A 181
 None
 0.74A 3ko0M-3r0zA:
undetectable
3ko0P-3r0zA:
undetectable		 3ko0M-3r0zA:
12.10
3ko0P-3r0zA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 8 GLY A 204
CYH A 231
PHE A 232
GLY A 181
 None
 0.73A 3ko0O-3r0zA:
undetectable
3ko0Q-3r0zA:
undetectable		 3ko0O-3r0zA:
12.10
3ko0Q-3r0zA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 7 GLY A 181
GLY A 204
CYH A 231
PHE A 232
 None
 0.72A 3ko0M-3r0zA:
undetectable
3ko0P-3r0zA:
undetectable		 3ko0M-3r0zA:
12.10
3ko0P-3r0zA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 10 ALA A 335
ASN A 168
SER A 114
ILE A 115
THR A 333
 None
SO4  A 451 (-3.9A)
SO4  A 451 ( 4.1A)
None
None
 1.37A 3qg2A-3r0zA:
undetectable		 3qg2A-3r0zA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 11 LEU A  20
ASP A 326
GLY A 341
PRO A 304
THR A 305
 None
 1.08A 3spkA-3r0zA:
undetectable		 3spkA-3r0zA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 11 SER A 114
ILE A 115
TRP A 420
LEU A 289
GLY A 245
 SO4  A 451 ( 4.1A)
None
None
None
None
 1.25A 4fogA-3r0zA:
undetectable		 4fogA-3r0zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 11 SER A 114
ILE A 115
TRP A 420
LEU A 289
GLY A 245
 SO4  A 451 ( 4.1A)
None
None
None
None
 1.30A 4fogC-3r0zA:
undetectable		 4fogC-3r0zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 7 ILE A 379
GLY A 113
ALA A 421
GLN A  67
 EDO  A 452 ( 4.4A)
None
None
None
 0.83A 4g0uB-3r0zA:
1.2		 4g0uB-3r0zA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 8 GLY A 277
LEU A 274
TRP A 420
PHE A 301
 SO4  A 449 (-3.4A)
None
None
None
 1.21A 4m5mA-3r0zA:
undetectable		 4m5mA-3r0zA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 GLY A 283
GLY A 281
THR A  43
GLY A 288
LEU A 291
 None
SO4  A 449 (-3.3A)
None
None
None
 1.25A 4n48A-3r0zA:
2.0		 4n48A-3r0zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		6 / 12 GLY A 283
PRO A 282
GLY A 280
LEU A 354
GLY A 288
LEU A 291
 None
SO4  A 449 (-4.3A)
SO4  A 449 (-3.6A)
None
None
None
 1.15A 4n48A-3r0zA:
2.0		 4n48A-3r0zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 GLY A 283
PRO A 282
GLY A 281
GLY A 288
LEU A 291
 None
SO4  A 449 (-4.3A)
SO4  A 449 (-3.3A)
None
None
 1.04A 4n48A-3r0zA:
2.0		 4n48A-3r0zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 ALA A 117
GLY A 119
ILE A 111
GLY A 113
ARG A 252
 None
 1.31A 4obwD-3r0zA:
undetectable		 4obwD-3r0zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 LEU A  61
ALA A  58
PHE A  57
ILE A 180
LEU A 147
 None
 1.04A 4psyA-3r0zA:
undetectable		 4psyA-3r0zA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 ALA A 286
VAL A 272
GLY A 250
GLY A 281
VAL A  47
 None
None
None
SO4  A 449 (-3.3A)
None
 0.87A 4q5mA-3r0zA:
undetectable		 4q5mA-3r0zA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 5 ALA A 194
ARG A 201
ALA A 192
GLU A 209
 None
 0.96A 5a06C-3r0zA:
2.5
5a06D-3r0zA:
2.5		 5a06C-3r0zA:
21.96
5a06D-3r0zA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 7 GLY A 348
SER A 344
GLY A 279
ALA A 350
 None
SO4  A 450 (-2.7A)
SO4  A 449 (-3.5A)
None
 0.98A 5e26A-3r0zA:
undetectable
5e26B-3r0zA:
1.5		 5e26A-3r0zA:
22.34
5e26B-3r0zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 LEU A  42
LEU A  37
ALA A  50
GLY A 283
LEU A 354
 None
 0.98A 5jw1B-3r0zA:
0.2		 5jw1B-3r0zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 7 ASN A  27
GLY A  29
ALA A  30
GLY A  36
 None
 0.59A 5kqyB-3r0zA:
undetectable		 5kqyB-3r0zA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 8 ASN A  27
GLY A  29
ALA A  30
GLY A  36
 None
 0.53A 5kr1B-3r0zA:
undetectable		 5kr1B-3r0zA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 PHE A  65
ILE A 175
SER A 112
GLY A 181
LEU A 148
 None
 1.09A 5m24A-3r0zA:
undetectable		 5m24A-3r0zA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		3 / 3 LYS A 105
TRP A 420
SER A 107
 EDO  A 452 (-3.3A)
None
None
 1.31A 5nwwA-3r0zA:
undetectable		 5nwwA-3r0zA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 3r0z D-SERINE DEHYDRATASE
(Salmonella
enterica) 		4 / 4 MET A 426
GLY A 425
HIS A 108
GLY A 113
 None
None
EDO  A 452 (-3.9A)
None
 0.97A 6fgdA-3r0zA:
undetectable		 6fgdA-3r0zA:
24.52