SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 6 TYR A  47
GLY A  46
ASP A 111
GLY A 354
None
0.92A 1eswA-3r11A:
2.9
1eswA-3r11A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 7 ASP A 111
GLY A 304
ALA A 279
ILE A 276
None
0.76A 1n49A-3r11A:
undetectable
1n49A-3r11A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 5 PHE A 353
LEU A 270
PHE A 355
SER A  33
None
1.26A 1wrkB-3r11A:
undetectable
1wrkB-3r11A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 8 LEU A 361
PHE A 353
PHE A 355
SER A  33
None
0.94A 1wrlC-3r11A:
undetectable
1wrlD-3r11A:
undetectable
1wrlC-3r11A:
15.77
1wrlD-3r11A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
3 / 3 PHE A  92
TYR A 109
TYR A  84
None
1.00A 1x70B-3r11A:
undetectable
1x70B-3r11A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 12 ALA A 286
ILE A 291
VAL A 248
ILE A 228
MET A 231
None
1.13A 2h42B-3r11A:
undetectable
2h42B-3r11A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 7 PRO A  51
SER A  33
ILE A  31
GLY A 304
None
0.69A 2y7kA-3r11A:
undetectable
2y7kA-3r11A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 12 GLY A  48
ALA A 104
GLY A 275
ILE A 276
ILE A 105
None
0.92A 2z54B-3r11A:
undetectable
2z54B-3r11A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 12 ALA A 286
ILE A 291
VAL A 248
ILE A 228
MET A 231
None
1.13A 3b2rA-3r11A:
undetectable
3b2rA-3r11A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 12 PHE A 355
LEU A 346
ASP A 331
PRO A 302
VAL A 328
None
1.06A 3dmhA-3r11A:
undetectable
3dmhA-3r11A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 10 ILE A 282
ALA A 279
GLN A 280
VAL A 257
ILE A 258
None
1.08A 3falA-3r11A:
undetectable
3falA-3r11A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 12 SER A 310
PHE A 311
ILE A 276
LEU A 107
ASP A 111
None
1.11A 3ko0G-3r11A:
undetectable
3ko0H-3r11A:
undetectable
3ko0I-3r11A:
undetectable
3ko0J-3r11A:
undetectable
3ko0G-3r11A:
12.40
3ko0H-3r11A:
12.40
3ko0I-3r11A:
12.40
3ko0J-3r11A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 11 LEU A 107
ASP A 111
SER A 310
PHE A 311
ILE A 276
None
1.09A 3ko0A-3r11A:
undetectable
3ko0B-3r11A:
undetectable
3ko0I-3r11A:
undetectable
3ko0J-3r11A:
undetectable
3ko0A-3r11A:
12.40
3ko0B-3r11A:
12.40
3ko0I-3r11A:
12.40
3ko0J-3r11A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 12 SER A 310
PHE A 311
ILE A 276
LEU A 107
ASP A 111
None
1.06A 3ko0K-3r11A:
undetectable
3ko0L-3r11A:
undetectable
3ko0S-3r11A:
undetectable
3ko0T-3r11A:
undetectable
3ko0K-3r11A:
12.40
3ko0L-3r11A:
12.40
3ko0S-3r11A:
12.40
3ko0T-3r11A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 12 LEU A 107
ASP A 111
SER A 310
PHE A 311
ILE A 276
None
1.11A 3ko0K-3r11A:
undetectable
3ko0L-3r11A:
undetectable
3ko0M-3r11A:
undetectable
3ko0N-3r11A:
undetectable
3ko0K-3r11A:
12.40
3ko0L-3r11A:
12.40
3ko0M-3r11A:
12.40
3ko0N-3r11A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
3 / 3 SER A 137
ASP A 321
ASN A 267
None
0.98A 3lsfB-3r11A:
undetectable
3lsfE-3r11A:
undetectable
3lsfB-3r11A:
20.68
3lsfE-3r11A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
3 / 3 ASP A 321
ASN A 267
SER A 137
None
0.96A 3lsfB-3r11A:
undetectable
3lsfE-3r11A:
undetectable
3lsfB-3r11A:
20.68
3lsfE-3r11A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
3 / 3 ASP A 321
ASN A 267
SER A 137
None
0.98A 3lslA-3r11A:
undetectable
3lslD-3r11A:
undetectable
3lslA-3r11A:
20.16
3lslD-3r11A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
3 / 3 SER A 137
ASP A 321
ASN A 267
None
0.95A 3lslA-3r11A:
undetectable
3lslD-3r11A:
undetectable
3lslA-3r11A:
20.16
3lslD-3r11A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 10 SER A 310
PHE A 311
ILE A 276
LEU A 107
ASP A 111
None
1.07A 3m0wC-3r11A:
undetectable
3m0wD-3r11A:
undetectable
3m0wE-3r11A:
undetectable
3m0wF-3r11A:
undetectable
3m0wC-3r11A:
12.14
3m0wD-3r11A:
12.14
3m0wE-3r11A:
12.14
3m0wF-3r11A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_G_P77G203_1
(PROTEIN S100-A4)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 9 SER A 310
PHE A 311
ILE A 276
LEU A 107
ASP A 111
None
1.10A 3m0wG-3r11A:
undetectable
3m0wH-3r11A:
undetectable
3m0wI-3r11A:
undetectable
3m0wJ-3r11A:
undetectable
3m0wG-3r11A:
12.14
3m0wH-3r11A:
12.14
3m0wI-3r11A:
12.14
3m0wJ-3r11A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 10 LEU A 107
ASP A 111
SER A 310
PHE A 311
ILE A 276
None
1.07A 3m0wE-3r11A:
undetectable
3m0wF-3r11A:
undetectable
3m0wG-3r11A:
undetectable
3m0wH-3r11A:
undetectable
3m0wE-3r11A:
12.14
3m0wF-3r11A:
12.14
3m0wG-3r11A:
12.14
3m0wH-3r11A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 10 LEU A 107
ASP A 111
SER A 310
PHE A 311
ILE A 276
None
1.11A 3m0wA-3r11A:
undetectable
3m0wB-3r11A:
undetectable
3m0wI-3r11A:
undetectable
3m0wJ-3r11A:
undetectable
3m0wA-3r11A:
12.14
3m0wB-3r11A:
12.14
3m0wI-3r11A:
12.14
3m0wJ-3r11A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 12 ILE A  68
PHE A  72
ALA A  35
THR A  10
ILE A   8
None
None
None
SO4  A 381 (-3.4A)
None
1.34A 3ndiA-3r11A:
2.2
3ndiA-3r11A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 12 ILE A 276
ALA A 307
PHE A  72
LEU A  88
THR A 308
None
1.22A 4cd2A-3r11A:
undetectable
4cd2A-3r11A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 9 SER A 120
ILE A 344
ALA A 309
LEU A 313
ALA A 127
None
1.42A 4fe1B-3r11A:
undetectable
4fe1B-3r11A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 6 ASN A 194
GLU A 220
TYR A 225
GLU A 246
MG  A 382 ( 4.7A)
MG  A 382 (-2.9A)
GOL  A 383 (-4.8A)
MG  A 382 ( 3.9A)
1.42A 4mi4A-3r11A:
1.3
4mi4A-3r11A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
3 / 3 LYS A 162
ASN A 215
ASP A 321
None
0.79A 4o1eA-3r11A:
11.3
4o1eA-3r11A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 6 ASN A 194
GLU A 220
TYR A 225
GLU A 246
MG  A 382 ( 4.7A)
MG  A 382 (-2.9A)
GOL  A 383 (-4.8A)
MG  A 382 ( 3.9A)
1.32A 4r87H-3r11A:
1.5
4r87H-3r11A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 10 SER A 120
ILE A 344
ALA A 309
LEU A 313
ALA A 127
None
1.46A 4xk8B-3r11A:
undetectable
4xk8B-3r11A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 7 ILE A  76
LEU A  81
ALA A 108
ILE A 105
None
0.80A 4y03A-3r11A:
undetectable
4y03A-3r11A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 10 ALA A  52
ASP A  32
GLY A  63
ILE A  67
VAL A  36
None
0.96A 5kr1A-3r11A:
undetectable
5kr1A-3r11A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 7 PHE A 355
PHE A 353
GLY A  48
GLY A  46
None
0.88A 5n9xA-3r11A:
2.4
5n9xA-3r11A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 7 ILE A 266
ASP A 250
LYS A 252
SER A  99
None
GOL  A 383 ( 3.8A)
GOL  A 383 (-3.0A)
None
1.10A 5nr3A-3r11A:
undetectable
5nr3A-3r11A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 10 SER A 120
ILE A 344
ALA A 309
LEU A 313
ALA A 127
None
1.42A 5oy0b-3r11A:
undetectable
5oy0b-3r11A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 12 ALA A 314
SER A 310
LEU A 346
ILE A 344
VAL A 295
None
1.24A 5vlmB-3r11A:
undetectable
5vlmB-3r11A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 5 LEU A 214
PHE A 183
LEU A 176
PHE A 205
None
1.21A 5x1fC-3r11A:
undetectable
5x1fJ-3r11A:
undetectable
5x1fC-3r11A:
18.91
5x1fJ-3r11A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
5 / 9 SER A 120
ILE A 344
ALA A 309
LEU A 313
ALA A 127
None
1.47A 6hqbB-3r11A:
undetectable
6hqbB-3r11A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia)
4 / 8 LEU A  61
ASP A  59
THR A  53
TRP A 327
None
0.96A 6nknC-3r11A:
undetectable
6nknN-3r11A:
undetectable
6nknP-3r11A:
undetectable
6nknC-3r11A:
18.91
6nknN-3r11A:
21.70
6nknP-3r11A:
18.91