SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r24'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EIZ_A_SAMA301_1 (FTSJ)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASP A 99 ASP A 114 ASP A 130	SAM A 302 (-2.6A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.37A	1eizA-3r24A: 14.9	1eizA-3r24A: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EJ0_A_SAMA301_1 (FTSJ)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASP A 99 ASP A 114 ASP A 130	SAM A 302 (-2.6A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.41A	1ej0A-3r24A: 14.8	1ej0A-3r24A: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FPQ_A_SAMA1699_0 (ISOLIQUIRITIGENIN 2'-O-METHYLTRANSFERA SE)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 10	GLY A 71 ASN A 43 ASP A 99 LEU A 100 ASP A 114	SAM A 302 (-3.7A) SAM A 302 (-3.5A) SAM A 302 (-2.6A) SAM A 302 (-4.4A) SAM A 302 (-3.4A)	1.36A	1fpqA-3r24A: 4.5	1fpqA-3r24A: 21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HZE_A_RBFA98_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 9	LEU A 180 LEU A 153 ILE A 128 THR A 191 ILE A 207	None	1.37A	1hzeA-3r24A: undetectable 1hzeB-3r24A: undetectable	1hzeA-3r24A: 14.24 1hzeB-3r24A: 14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HZE_B_RBFB99_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 9	THR A 191 ILE A 207 LEU A 180 LEU A 153 ILE A 128	None	1.37A	1hzeA-3r24A: undetectable 1hzeB-3r24A: undetectable	1hzeA-3r24A: 14.24 1hzeB-3r24A: 14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I18_A_RBFA98_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 10	LEU A 180 LEU A 153 ILE A 128 THR A 191 ILE A 207	None	1.41A	1i18A-3r24A: undetectable 1i18B-3r24A: undetectable	1i18A-3r24A: 14.24 1i18B-3r24A: 14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I18_B_RBFB99_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 10	THR A 191 ILE A 207 LEU A 180 LEU A 153 ILE A 128	None	1.42A	1i18A-3r24A: undetectable 1i18B-3r24A: undetectable	1i18A-3r24A: 14.24 1i18B-3r24A: 14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IGX_A_EPAA700_1 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	LEU A 54 GLY A 208 ALA A 209 SER A 166 GLY A 164	None	1.15A	1igxA-3r24A: undetectable	1igxA-3r24A: 17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S9Q_B_CHDB500_0 (ESTROGEN-RELATED RECEPTOR GAMMA)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 4	LEU A 206 VAL A 169 ILE A 167 TRP A 190	None	1.12A	1s9qB-3r24A: undetectable	1s9qB-3r24A: 28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B25_A_SAMA601_0 (HYPOTHETICAL PROTEIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 MET A 131	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-3.4A) SAM A 302 (-3.4A) SAM A 302 (-3.7A)	1.01A	2b25A-3r24A: 8.5	2b25A-3r24A: 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_A_SAMA1001_1 (SAM DEPENDENT METHYLTRANSFERASE)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASP A 99 ASP A 114 ASP A 130	SAM A 302 (-2.6A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.72A	2igtA-3r24A: 8.5	2igtA-3r24A: 22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_B_SAMB1002_1 (SAM DEPENDENT METHYLTRANSFERASE)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASP A 99 ASP A 114 ASP A 130	SAM A 302 (-2.6A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.73A	2igtB-3r24A: 8.5	2igtB-3r24A: 22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_C_SAMC300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 LEU A 100 ASP A 130 LYS A 170	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-4.4A) SAM A 302 (-3.6A) SAM A 302 (-3.1A)	0.90A	2oxtC-3r24A: 11.1	2oxtC-3r24A: 23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DOU_A_SAMA1_1 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASP A 99 ASP A 114 ASP A 130	SAM A 302 (-2.6A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.36A	3douA-3r24A: 13.3	3douA-3r24A: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_C_MTXC164_2 (DIHYDROFOLATE REDUCTASE)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 4	ILE A 128 ARG A 283 ILE A 127 THR A 82	None	1.22A	3ia4C-3r24A: undetectable	3ia4C-3r24A: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LB3_B_4CHB192_0 (DEHALOPEROXIDASE A)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 6	TYR A 152 HIS A 119 THR A 120 VAL A 290	None	1.17A	3lb3B-3r24A: undetectable	3lb3B-3r24A: 16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P97_A_SAMA263_0 (NON-STRUCTURAL PROTEIN 5)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-3.4A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.88A	3p97A-3r24A: 10.4	3p97A-3r24A: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P97_C_SAMC263_0 (NON-STRUCTURAL PROTEIN 5)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-3.4A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.87A	3p97C-3r24A: 10.5	3p97C-3r24A: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R24_A_SAMA302_0 (2'-O-METHYL TRANSFERASE)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	12 / 12	ASN A 43 GLY A 71 SER A 74 PRO A 80 GLY A 81 LEU A 100 ASN A 101 ASP A 114 CYH A 115 MET A 131 PHE A 149 LYS A 170	SAM A 302 (-3.5A) SAM A 302 (-3.7A) SAM A 302 ( 4.4A) SAM A 302 (-3.8A) SAM A 302 (-3.4A) SAM A 302 (-4.4A) SAM A 302 (-4.0A) SAM A 302 (-3.4A) SAM A 302 (-3.7A) SAM A 302 (-3.7A) SAM A 302 ( 4.8A) SAM A 302 (-3.1A)	0.07A	3r24A-3r24A: 54.4	3r24A-3r24A: undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3R24_A_SAMA302_1 (2'-O-METHYL TRANSFERASE)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	TYR A 47 ASP A 99 ASP A 130	SAM A 302 (-4.5A) SAM A 302 (-2.6A) SAM A 302 (-3.6A)	0.00A	3r24A-3r24A: 54.4	3r24A-3r24A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UR0_B_SVRB516_1 (RNA-DEPENDENT RNA POLYMERASE)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 7	GLY A 81 ALA A 83 ALA A 107 ARG A 86	SAM A 302 (-3.4A) None None None	0.87A	3ur0B-3r24A: undetectable	3ur0B-3r24A: 22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B17_A_SAMA1358_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	6 / 12	GLY A 71 GLY A 81 ASP A 99 ASP A 114 ASP A 130 MET A 131	SAM A 302 (-3.7A) SAM A 302 (-3.4A) SAM A 302 (-2.6A) SAM A 302 (-3.4A) SAM A 302 (-3.6A) SAM A 302 (-3.7A)	0.99A	4b17A-3r24A: 9.7	4b17A-3r24A: 22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G77_A_TLFA711_0 (LACTOTRANSFERRIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 7	ILE A 128 LEU A 126 ALA A 168 TYR A 47	None None None SAM A 302 (-4.5A)	0.73A	4g77A-3r24A: undetectable	4g77A-3r24A: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M5M_A_DX4A401_0 (2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 8	GLY A 278 LEU A 57 ASN A 210 ARG A 255	None	1.15A	4m5mA-3r24A: undetectable	4m5mA-3r24A: 16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XYZ_A_ACTA103_0 (POLYUBIQUITIN-C)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 4	LEU A 95 ILE A 128 HIS A 69 VAL A 67	None	1.18A	4xyzA-3r24A: undetectable	4xyzA-3r24A: 13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E9Q_C_SAMC4000_0 (GENOME POLYPROTEIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-3.4A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.86A	5e9qC-3r24A: 9.8	5e9qC-3r24A: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EC8_C_SAMC4000_0 (GENOME POLYPROTEIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-3.4A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.89A	5ec8C-3r24A: 10.6	5ec8C-3r24A: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EIF_A_SAMA301_0 (GENOME POLYPROTEIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-3.4A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.88A	5eifA-3r24A: 10.2	5eifA-3r24A: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EIF_C_SAMC4000_0 (GENOME POLYPROTEIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-3.4A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.86A	5eifC-3r24A: 10.0	5eifC-3r24A: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KQS_A_SAMA307_0 (GENOME POLYPROTEIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-3.4A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.89A	5kqsA-3r24A: 9.6	5kqsA-3r24A: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NJV_A_SAMA301_0 (NS5)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-3.4A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.88A	5njvA-3r24A: 10.6	5njvA-3r24A: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NJV_B_SAMB301_0 (NS5)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-3.4A) SAM A 302 (-3.4A) SAM A 302 (-3.6A)	0.89A	5njvB-3r24A: 9.7	5njvB-3r24A: 20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5YN6_A_SAMA401_0 (NSP16 PROTEIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	11 / 12	TYR A 47 GLY A 71 PRO A 80 GLY A 81 LEU A 100 ASN A 101 ASP A 114 CYH A 115 ASP A 130 MET A 131 PHE A 149	SAM A 302 (-4.5A) SAM A 302 (-3.7A) SAM A 302 (-3.8A) SAM A 302 (-3.4A) SAM A 302 (-4.4A) SAM A 302 (-4.0A) SAM A 302 (-3.4A) SAM A 302 (-3.7A) SAM A 302 (-3.6A) SAM A 302 (-3.7A) SAM A 302 ( 4.8A)	0.43A	5yn6A-3r24A: 45.9	5yn6A-3r24A: 65.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5YNI_A_SAMA401_0 (NSP16 PROTEIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	11 / 12	TYR A 47 GLY A 71 PRO A 80 GLY A 81 ASP A 99 LEU A 100 ASN A 101 ASP A 114 CYH A 115 ASP A 130 MET A 131	SAM A 302 (-4.5A) SAM A 302 (-3.7A) SAM A 302 (-3.8A) SAM A 302 (-3.4A) SAM A 302 (-2.6A) SAM A 302 (-4.4A) SAM A 302 (-4.0A) SAM A 302 (-3.4A) SAM A 302 (-3.7A) SAM A 302 (-3.6A) SAM A 302 (-3.7A)	0.41A	5yniA-3r24A: 46.2	5yniA-3r24A: 65.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5YNM_A_SAMA401_0 (NSP16 PROTEIN)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	11 / 12	TYR A 47 GLY A 71 PRO A 80 GLY A 81 ASP A 99 LEU A 100 ASN A 101 ASP A 114 CYH A 115 ASP A 130 MET A 131	SAM A 302 (-4.5A) SAM A 302 (-3.7A) SAM A 302 (-3.8A) SAM A 302 (-3.4A) SAM A 302 (-2.6A) SAM A 302 (-4.4A) SAM A 302 (-4.0A) SAM A 302 (-3.4A) SAM A 302 (-3.7A) SAM A 302 (-3.6A) SAM A 302 (-3.7A)	0.42A	5ynmA-3r24A: 46.2	5ynmA-3r24A: 65.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DM0_B_CYZB1302_0 (GLUTAMATE RECEPTOR 2,VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 10	LEU A 161 LEU A 275 ILE A 167 SER A 188 GLY A 208	None	1.27A	6dm0B-3r24A: 3.7 6dm0C-3r24A: 2.4	6dm0B-3r24A: 11.05 6dm0C-3r24A: 11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6I5Z_D_SAMD401_0 (O-METHYLTRANSFERASE 1)	3r24	2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 11	GLY A 71 GLY A 73 ASP A 99 LEU A 100 ASP A 114	SAM A 302 (-3.7A) SAM A 302 (-4.1A) SAM A 302 (-2.6A) SAM A 302 (-4.4A) SAM A 302 (-3.4A)	0.85A	6i5zD-3r24A: 6.4	6i5zD-3r24A: 23.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EIZ_A_SAMA301_1","FTSJ","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"ASP A  99;ASP A 114;ASP A 130","SAM A 302 (-2.6A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.37A","1eizA-3r24A:14.9","1eizA-3r24A:20.94"],["1EJ0_A_SAMA301_1","FTSJ","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"ASP A  99;ASP A 114;ASP A 130","SAM A 302 (-2.6A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.41A","1ej0A-3r24A:14.8","1ej0A-3r24A:20.94"],["1FPQ_A_SAMA1699_0","ISOLIQUIRITIGENIN 2'-O-METHYLTRANSFERASE","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;ASN A  43;ASP A  99;LEU A 100;ASP A 114","SAM A 302 (-3.7A);SAM A 302 (-3.5A);SAM A 302 (-2.6A);SAM A 302 (-4.4A);SAM A 302 (-3.4A)","1.36A","1fpqA-3r24A:4.5","1fpqA-3r24A:21.17"],["1HZE_A_RBFA98_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"LEU A 180;LEU A 153;ILE A 128;THR A 191;ILE A 207","None","1.37A","1hzeA-3r24A:undetectable;1hzeB-3r24A:undetectable","1hzeA-3r24A:14.24;1hzeB-3r24A:14.24"],["1HZE_B_RBFB99_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"THR A 191;ILE A 207;LEU A 180;LEU A 153;ILE A 128","None","1.37A","1hzeA-3r24A:undetectable;1hzeB-3r24A:undetectable","1hzeA-3r24A:14.24;1hzeB-3r24A:14.24"],["1I18_A_RBFA98_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"LEU A 180;LEU A 153;ILE A 128;THR A 191;ILE A 207","None","1.41A","1i18A-3r24A:undetectable;1i18B-3r24A:undetectable","1i18A-3r24A:14.24;1i18B-3r24A:14.24"],["1I18_B_RBFB99_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"THR A 191;ILE A 207;LEU A 180;LEU A 153;ILE A 128","None","1.42A","1i18A-3r24A:undetectable;1i18B-3r24A:undetectable","1i18A-3r24A:14.24;1i18B-3r24A:14.24"],["1IGX_A_EPAA700_1","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"LEU A  54;GLY A 208;ALA A 209;SER A 166;GLY A 164","None","1.15A","1igxA-3r24A:undetectable","1igxA-3r24A:17.19"],["1S9Q_B_CHDB500_0","ESTROGEN-RELATED RECEPTOR GAMMA","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"LEU A 206;VAL A 169;ILE A 167;TRP A 190","None","1.12A","1s9qB-3r24A:undetectable","1s9qB-3r24A:28.03"],["2B25_A_SAMA601_0","HYPOTHETICAL PROTEIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;MET A 131","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-3.4A);SAM A 302 (-3.4A);SAM A 302 (-3.7A)","1.01A","2b25A-3r24A:8.5","2b25A-3r24A:20.64"],["2IGT_A_SAMA1001_1","SAM DEPENDENT METHYLTRANSFERASE","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"ASP A  99;ASP A 114;ASP A 130","SAM A 302 (-2.6A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.72A","2igtA-3r24A:8.5","2igtA-3r24A:22.75"],["2IGT_B_SAMB1002_1","SAM DEPENDENT METHYLTRANSFERASE","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"ASP A  99;ASP A 114;ASP A 130","SAM A 302 (-2.6A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.73A","2igtB-3r24A:8.5","2igtB-3r24A:22.75"],["2OXT_C_SAMC300_0","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;LEU A 100;ASP A 130;LYS A 170","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-4.4A);SAM A 302 (-3.6A);SAM A 302 (-3.1A)","0.90A","2oxtC-3r24A:11.1","2oxtC-3r24A:23.51"],["3DOU_A_SAMA1_1","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"ASP A  99;ASP A 114;ASP A 130","SAM A 302 (-2.6A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.36A","3douA-3r24A:13.3","3douA-3r24A:22.38"],["3IA4_C_MTXC164_2","DIHYDROFOLATE REDUCTASE","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"ILE A 128;ARG A 283;ILE A 127;THR A  82","None","1.22A","3ia4C-3r24A:undetectable","3ia4C-3r24A:20.29"],["3LB3_B_4CHB192_0","DEHALOPEROXIDASE A","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"TYR A 152;HIS A 119;THR A 120;VAL A 290","None","1.17A","3lb3B-3r24A:undetectable","3lb3B-3r24A:16.26"],["3P97_A_SAMA263_0","NON-STRUCTURAL PROTEIN 5","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-3.4A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.88A","3p97A-3r24A:10.4","3p97A-3r24A:20.29"],["3P97_C_SAMC263_0","NON-STRUCTURAL PROTEIN 5","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-3.4A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.87A","3p97C-3r24A:10.5","3p97C-3r24A:20.29"],["3R24_A_SAMA302_0","2'-O-METHYL TRANSFERASE","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",12,"ASN A  43;GLY A  71;SER A  74;PRO A  80;GLY A  81;LEU A 100;ASN A 101;ASP A 114;CYH A 115;MET A 131;PHE A 149;LYS A 170","SAM A 302 (-3.5A);SAM A 302 (-3.7A);SAM A 302 ( 4.4A);SAM A 302 (-3.8A);SAM A 302 (-3.4A);SAM A 302 (-4.4A);SAM A 302 (-4.0A);SAM A 302 (-3.4A);SAM A 302 (-3.7A);SAM A 302 (-3.7A);SAM A 302 ( 4.8A);SAM A 302 (-3.1A)","0.07A","3r24A-3r24A:54.4","3r24A-3r24A:undetectable"],["3R24_A_SAMA302_1","2'-O-METHYL TRANSFERASE","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"TYR A  47;ASP A  99;ASP A 130","SAM A 302 (-4.5A);SAM A 302 (-2.6A);SAM A 302 (-3.6A)","0.00A","3r24A-3r24A:54.4","3r24A-3r24A:100.00"],["3UR0_B_SVRB516_1","RNA-DEPENDENT RNA POLYMERASE","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"GLY A  81;ALA A  83;ALA A 107;ARG A  86","SAM A 302 (-3.4A);None;None;None","0.87A","3ur0B-3r24A:undetectable","3ur0B-3r24A:22.16"],["4B17_A_SAMA1358_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",6,"GLY A  71;GLY A  81;ASP A  99;ASP A 114;ASP A 130;MET A 131","SAM A 302 (-3.7A);SAM A 302 (-3.4A);SAM A 302 (-2.6A);SAM A 302 (-3.4A);SAM A 302 (-3.6A);SAM A 302 (-3.7A)","0.99A","4b17A-3r24A:9.7","4b17A-3r24A:22.54"],["4G77_A_TLFA711_0","LACTOTRANSFERRIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"ILE A 128;LEU A 126;ALA A 168;TYR A  47","None;None;None;SAM A 302 (-4.5A)","0.73A","4g77A-3r24A:undetectable","4g77A-3r24A:21.43"],["4M5M_A_DX4A401_0","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"GLY A 278;LEU A  57;ASN A 210;ARG A 255","None","1.15A","4m5mA-3r24A:undetectable","4m5mA-3r24A:16.37"],["4XYZ_A_ACTA103_0","POLYUBIQUITIN-C","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"LEU A  95;ILE A 128;HIS A  69;VAL A  67","None","1.18A","4xyzA-3r24A:undetectable","4xyzA-3r24A:13.27"],["5E9Q_C_SAMC4000_0","GENOME POLYPROTEIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-3.4A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.86A","5e9qC-3r24A:9.8","5e9qC-3r24A:19.58"],["5EC8_C_SAMC4000_0","GENOME POLYPROTEIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-3.4A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.89A","5ec8C-3r24A:10.6","5ec8C-3r24A:19.58"],["5EIF_A_SAMA301_0","GENOME POLYPROTEIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-3.4A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.88A","5eifA-3r24A:10.2","5eifA-3r24A:19.58"],["5EIF_C_SAMC4000_0","GENOME POLYPROTEIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-3.4A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.86A","5eifC-3r24A:10.0","5eifC-3r24A:19.58"],["5KQS_A_SAMA307_0","GENOME POLYPROTEIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-3.4A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.89A","5kqsA-3r24A:9.6","5kqsA-3r24A:20.73"],["5NJV_A_SAMA301_0","NS5","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-3.4A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.88A","5njvA-3r24A:10.6","5njvA-3r24A:20.45"],["5NJV_B_SAMB301_0","NS5","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-3.4A);SAM A 302 (-3.4A);SAM A 302 (-3.6A)","0.89A","5njvB-3r24A:9.7","5njvB-3r24A:20.45"],["5YN6_A_SAMA401_0","NSP16 PROTEIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",11,"TYR A  47;GLY A  71;PRO A  80;GLY A  81;LEU A 100;ASN A 101;ASP A 114;CYH A 115;ASP A 130;MET A 131;PHE A 149","SAM A 302 (-4.5A);SAM A 302 (-3.7A);SAM A 302 (-3.8A);SAM A 302 (-3.4A);SAM A 302 (-4.4A);SAM A 302 (-4.0A);SAM A 302 (-3.4A);SAM A 302 (-3.7A);SAM A 302 (-3.6A);SAM A 302 (-3.7A);SAM A 302 ( 4.8A)","0.43A","5yn6A-3r24A:45.9","5yn6A-3r24A:65.10"],["5YNI_A_SAMA401_0","NSP16 PROTEIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",11,"TYR A  47;GLY A  71;PRO A  80;GLY A  81;ASP A  99;LEU A 100;ASN A 101;ASP A 114;CYH A 115;ASP A 130;MET A 131","SAM A 302 (-4.5A);SAM A 302 (-3.7A);SAM A 302 (-3.8A);SAM A 302 (-3.4A);SAM A 302 (-2.6A);SAM A 302 (-4.4A);SAM A 302 (-4.0A);SAM A 302 (-3.4A);SAM A 302 (-3.7A);SAM A 302 (-3.6A);SAM A 302 (-3.7A)","0.41A","5yniA-3r24A:46.2","5yniA-3r24A:65.10"],["5YNM_A_SAMA401_0","NSP16 PROTEIN","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",11,"TYR A  47;GLY A  71;PRO A  80;GLY A  81;ASP A  99;LEU A 100;ASN A 101;ASP A 114;CYH A 115;ASP A 130;MET A 131","SAM A 302 (-4.5A);SAM A 302 (-3.7A);SAM A 302 (-3.8A);SAM A 302 (-3.4A);SAM A 302 (-2.6A);SAM A 302 (-4.4A);SAM A 302 (-4.0A);SAM A 302 (-3.4A);SAM A 302 (-3.7A);SAM A 302 (-3.6A);SAM A 302 (-3.7A)","0.42A","5ynmA-3r24A:46.2","5ynmA-3r24A:65.10"],["6DM0_B_CYZB1302_0","GLUTAMATE RECEPTOR 2,VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"LEU A 161;LEU A 275;ILE A 167;SER A 188;GLY A 208","None","1.27A","6dm0B-3r24A:3.7;6dm0C-3r24A:2.4","6dm0B-3r24A:11.05;6dm0C-3r24A:11.05"],["6I5Z_D_SAMD401_0","O-METHYLTRANSFERASE 1","3r24","2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;ASP A  99;LEU A 100;ASP A 114","SAM A 302 (-3.7A);SAM A 302 (-4.1A);SAM A 302 (-2.6A);SAM A 302 (-4.4A);SAM A 302 (-3.4A)","0.85A","6i5zD-3r24A:6.4","6i5zD-3r24A:23.75"]]