SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M9Q_B_BEZB251_0 (SERINE PROTEASE INHIBITOR SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3)	3r27	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L (Homo sapiens)	5 / 9	LEU A 118 ILE A 162 PHE A 144 VAL A 171 ALA A 140	None GOL A 181 (-4.6A) None None None	0.89A	2m9qA-3r27A: undetectable	2m9qA-3r27A: 15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LOQ_A_ACTA279_0 (UNIVERSAL STRESS PROTEIN)	3r27	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L (Homo sapiens)	4 / 4	SER A 101 SER A 176 THR A 175 SER A 174	None None GOL A 182 (-3.1A) GOL A 182 (-2.6A)	1.45A	3loqA-3r27A: undetectable	3loqA-3r27A: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CZM_B_HISB402_0 (ATP PHOSPHORIBOSYLTRANSF ERASE CATALYTIC SUBUNIT)	3r27	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L (Homo sapiens)	5 / 9	VAL A 142 LEU A 118 GLY A 108 LEU A 109 VAL A 171	None	1.34A	6czmA-3r27A: 3.3 6czmB-3r27A: 3.2	6czmA-3r27A: 11.21 6czmB-3r27A: 11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CZM_F_HISF402_0 (ATP PHOSPHORIBOSYLTRANSF ERASE CATALYTIC SUBUNIT)	3r27	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L (Homo sapiens)	5 / 10	VAL A 142 LEU A 118 GLY A 108 LEU A 109 VAL A 171	None	1.30A	6czmE-3r27A: undetectable 6czmF-3r27A: 3.3	6czmE-3r27A: 11.21 6czmF-3r27A: 11.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2M9Q_B_BEZB251_0","SERINE PROTEASE INHIBITOR;SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3","3r27","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L","Homo sapiens",5,"LEU A 118;ILE A 162;PHE A 144;VAL A 171;ALA A 140","None;GOL A 181 (-4.6A);None;None;None","0.89A","2m9qA-3r27A:undetectable","2m9qA-3r27A:15.42"],["3LOQ_A_ACTA279_0","UNIVERSAL STRESS PROTEIN","3r27","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L","Homo sapiens",4,"SER A 101;SER A 176;THR A 175;SER A 174","None;None;GOL A 182 (-3.1A);GOL A 182 (-2.6A)","1.45A","3loqA-3r27A:undetectable","3loqA-3r27A:18.15"],["6CZM_B_HISB402_0","ATP PHOSPHORIBOSYLTRANSFERASE CATALYTIC SUBUNIT","3r27","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L","Homo sapiens",5,"VAL A 142;LEU A 118;GLY A 108;LEU A 109;VAL A 171","None","1.34A","6czmA-3r27A:3.3;6czmB-3r27A:3.2","6czmA-3r27A:11.21;6czmB-3r27A:11.21"],["6CZM_F_HISF402_0","ATP PHOSPHORIBOSYLTRANSFERASE CATALYTIC SUBUNIT","3r27","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L","Homo sapiens",5,"VAL A 142;LEU A 118;GLY A 108;LEU A 109;VAL A 171","None","1.30A","6czmE-3r27A:undetectable;6czmF-3r27A:3.3","6czmE-3r27A:11.21;6czmF-3r27A:11.21"]]