SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 ASP A  34
LEU A  39
ILE A 144
SER A  94
PHE A  92
 None
 1.33A 1xmuA-3r2gA:
undetectable		 1xmuA-3r2gA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 ASP A  34
LEU A  39
ILE A 144
SER A  94
PHE A  92
 None
 1.37A 1xoqA-3r2gA:
undetectable		 1xoqA-3r2gA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 ALA A  70
VAL A 203
ALA A 204
LEU A 218
ILE A 208
 None
 1.07A 2h42B-3r2gA:
undetectable		 2h42B-3r2gA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		3 / 3 PRO A 283
PHE A 242
LYS A 249
 None
 1.25A 3bjwG-3r2gA:
undetectable		 3bjwG-3r2gA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 THR A 237
GLY A 229
SER A 234
HIS A  72
SER A 258
 None
 1.19A 3mg02-3r2gA:
undetectable
3mg0V-3r2gA:
undetectable		 3mg02-3r2gA:
20.57
3mg0V-3r2gA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 9 GLY A 162
ALA A 163
ASP A 164
ILE A 165
LEU A 158
 None
 0.74A 3ogpA-3r2gA:
undetectable		 3ogpA-3r2gA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 9 GLY A 162
ALA A 163
ASP A 164
ILE A 165
LEU A 158
 None
 0.79A 3ogpB-3r2gA:
undetectable		 3ogpB-3r2gA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 GLY A 162
ALA A 163
ASP A 164
ILE A 165
LEU A 158
 None
 0.77A 3ogqB-3r2gA:
undetectable		 3ogqB-3r2gA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 LEU A 218
GLY A 298
GLY A 302
ILE A 214
LEU A  43
 None
 1.20A 3uj7B-3r2gA:
undetectable		 3uj7B-3r2gA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 7 ASN A 148
GLY A 169
PHE A  10
ILE A 208
 None
 0.90A 4fglC-3r2gA:
undetectable		 4fglC-3r2gA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		6 / 9 ASP A 119
ASN A 148
ILE A 170
GLY A 171
THR A 178
ASP A 205
 None
 0.47A 4fxsA-3r2gA:
38.7		 4fxsA-3r2gA:
30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 7 TYR A 157
VAL A 149
ILE A 166
ARG A 200
ALA A 163
 None
 1.41A 4lv9A-3r2gA:
2.6		 4lv9A-3r2gA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 11 PRO A  44
ALA A  67
PHE A 224
SER A  47
THR A  40
 None
 1.30A 4mmaA-3r2gA:
undetectable		 4mmaA-3r2gA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 6 ARG A 109
ALA A 105
ASP A 110
LEU A 102
 None
 1.11A 4ot2A-3r2gA:
undetectable		 4ot2A-3r2gA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 6 ILE A 291
VAL A  45
PHE A  61
THR A  54
 None
 1.17A 4xe5A-3r2gA:
undetectable		 4xe5A-3r2gA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 5 ALA A 222
ALA A 204
ILE A 192
LEU A 189
 None
 0.34A 5jncD-3r2gA:
undetectable		 5jncD-3r2gA:
21.10