SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r2j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 12 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.24A 1q23B-3r2jA:
undetectable		 1q23B-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 12 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.30A 1q23C-3r2jA:
undetectable		 1q23C-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 10 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.22A 1q23E-3r2jA:
undetectable		 1q23E-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 12 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.25A 1q23H-3r2jA:
undetectable
1q23I-3r2jA:
undetectable		 1q23H-3r2jA:
20.00
1q23I-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 11 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.26A 1q23I-3r2jA:
undetectable		 1q23I-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 11 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.25A 1q23J-3r2jA:
undetectable		 1q23J-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 10 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.21A 1q23K-3r2jA:
undetectable		 1q23K-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 11 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.24A 1q23L-3r2jA:
undetectable		 1q23L-3r2jA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 10 ASP A  32
ASP A  73
HIS A  75
TYR A 126
PHE A 160
 NIO  A 311 (-3.9A)
ZN  A 301 ( 2.5A)
ZN  A 301 (-3.4A)
None
None
 1.37A 2wt9A-3r2jA:
30.2		 2wt9A-3r2jA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		9 / 10 ASP A  32
PHE A  37
LEU A  44
ASP A  73
TRP A  89
HIS A  92
TYR A 126
ALA A 157
PHE A 160
 NIO  A 311 (-3.9A)
None
None
ZN  A 301 ( 2.5A)
NIO  A 311 (-3.4A)
ZN  A 301 ( 3.4A)
None
NIO  A 311 (-3.3A)
None
 0.42A 2wt9A-3r2jA:
30.2		 2wt9A-3r2jA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WT9_B_NIOB1216_1
(NICOTINAMIDASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		8 / 9 ASP A  32
PHE A  37
LEU A  44
ASP A  73
TRP A  89
HIS A  92
ALA A 157
PHE A 160
 NIO  A 311 (-3.9A)
None
None
ZN  A 301 ( 2.5A)
NIO  A 311 (-3.4A)
ZN  A 301 ( 3.4A)
NIO  A 311 (-3.3A)
None
 0.40A 2wt9B-3r2jA:
30.1		 2wt9B-3r2jA:
37.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		3 / 3 CYH A  80
HIS A  85
PHE A  82
 None
 1.14A 3cr4X-3r2jA:
undetectable		 3cr4X-3r2jA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		4 / 6 GLN A  34
HIS A  75
HIS A  92
ASP A  32
 None
ZN  A 301 (-3.4A)
ZN  A 301 ( 3.4A)
NIO  A 311 (-3.9A)
 1.05A 3nvcA-3r2jA:
undetectable		 3nvcA-3r2jA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		6 / 11 ASP A  32
PHE A  37
LEU A  44
ASP A  73
HIS A  92
TYR A 126
 NIO  A 311 (-3.9A)
None
None
ZN  A 301 ( 2.5A)
ZN  A 301 ( 3.4A)
None
 0.49A 3o94A-3r2jA:
23.3		 3o94A-3r2jA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		6 / 11 ASP A  32
PHE A  37
LEU A  44
ASP A  73
HIS A  92
TYR A 126
 NIO  A 311 (-3.9A)
None
None
ZN  A 301 ( 2.5A)
ZN  A 301 ( 3.4A)
None
 0.49A 3o94B-3r2jA:
23.2		 3o94B-3r2jA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		6 / 11 ASP A  32
PHE A  37
LEU A  44
ASP A  73
HIS A  92
TYR A 126
 NIO  A 311 (-3.9A)
None
None
ZN  A 301 ( 2.5A)
ZN  A 301 ( 3.4A)
None
 0.49A 3o94C-3r2jA:
23.2		 3o94C-3r2jA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		6 / 11 ASP A  32
PHE A  37
LEU A  44
ASP A  73
HIS A  92
TYR A 126
 NIO  A 311 (-3.9A)
None
None
ZN  A 301 ( 2.5A)
ZN  A 301 ( 3.4A)
None
 0.50A 3o94D-3r2jA:
23.2		 3o94D-3r2jA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		4 / 5 ASP A  73
GLU A 131
THR A 120
SER A  43
 ZN  A 301 ( 2.5A)
None
None
None
 1.45A 3p2kC-3r2jA:
undetectable		 3p2kC-3r2jA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 12 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.16A 3u9fB-3r2jA:
undetectable
3u9fC-3r2jA:
undetectable		 3u9fB-3r2jA:
20.00
3u9fC-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 10 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.21A 3u9fE-3r2jA:
undetectable		 3u9fE-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 12 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.14A 3u9fH-3r2jA:
undetectable
3u9fI-3r2jA:
undetectable		 3u9fH-3r2jA:
20.00
3u9fI-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 10 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.19A 3u9fI-3r2jA:
undetectable		 3u9fI-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 12 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.16A 3u9fJ-3r2jA:
undetectable
3u9fK-3r2jA:
undetectable		 3u9fJ-3r2jA:
20.00
3u9fK-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 10 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.21A 3u9fK-3r2jA:
undetectable		 3u9fK-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 11 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.18A 3u9fN-3r2jA:
undetectable
3u9fO-3r2jA:
undetectable		 3u9fN-3r2jA:
20.00
3u9fO-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 9 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.14A 3u9fP-3r2jA:
undetectable		 3u9fP-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 12 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.18A 3u9fP-3r2jA:
undetectable
3u9fS-3r2jA:
undetectable		 3u9fP-3r2jA:
20.00
3u9fS-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		4 / 7 ASP A  73
ASP A 124
SER A  81
HIS A  92
 ZN  A 301 ( 2.5A)
ZN  A 301 ( 4.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 ( 3.4A)
 0.96A 4k7gB-3r2jA:
undetectable		 4k7gB-3r2jA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 9 ALA A 166
ALA A 169
LEU A 143
LEU A 178
VAL A 177
 None
 1.37A 4or0A-3r2jA:
undetectable		 4or0A-3r2jA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		4 / 8 LEU A 102
ASP A  32
ALA A  70
VAL A  69
 None
NIO  A 311 (-3.9A)
None
None
 0.88A 4zbqA-3r2jA:
undetectable		 4zbqA-3r2jA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN
(Leishmania
infantum) 		5 / 10 GLY A 155
GLN A  62
ASN A  57
LEU A  53
LEU A  38
 None
 1.27A 5fhzC-3r2jA:
3.3		 5fhzC-3r2jA:
20.11