SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 4 LEU A 182
GLY A 190
ASP A 205
TYR A 183
 None
 1.44A 1oxrA-3r2tA:
undetectable		 1oxrA-3r2tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 6 VAL A 119
SER A 118
LEU A 210
PHE A 104
 None
 1.32A 2f8dA-3r2tA:
undetectable		 2f8dA-3r2tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A 224
LEU A 165
ILE A 192
ARG A 173
ILE A 227
 None
 0.99A 3ql3A-3r2tA:
undetectable		 3ql3A-3r2tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 5 TYR A  49
SER A  54
ASP A 169
ASP A 211
 None
None
None
SO4  A 234 (-2.2A)
 1.39A 3uj7B-3r2tA:
undetectable		 3uj7B-3r2tA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 11 ARG A 214
VAL A 163
PRO A 137
PHE A 156
ILE A 227
 None
 1.19A 4j4vD-3r2tA:
undetectable
4j4vE-3r2tA:
undetectable		 4j4vD-3r2tA:
22.97
4j4vE-3r2tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ALA A 187
LEU A 206
LYS A 142
ILE A 172
LEU A 139
 None
 1.12A 4ky8C-3r2tA:
undetectable		 4ky8C-3r2tA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ALA A 187
LEU A 206
LYS A 142
ILE A 172
LEU A 139
 None
 1.16A 4q0dA-3r2tA:
undetectable		 4q0dA-3r2tA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ALA A 187
LEU A 206
LYS A 142
ILE A 172
LEU A 139
 None
 1.16A 4q0dB-3r2tA:
undetectable		 4q0dB-3r2tA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ALA A 187
LEU A 206
LYS A 142
ILE A 172
LEU A 139
 None
 1.16A 4q0dE-3r2tA:
undetectable		 4q0dE-3r2tA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ASP A 169
ILE A 172
ARG A 173
LEU A 206
ASN A 226
 None
 0.91A 5il1A-3r2tA:
undetectable		 5il1A-3r2tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 11 VAL A 122
ASP A 102
GLU A 162
TYR A  94
LEU A  86
 None
 1.12A 5jh7B-3r2tA:
undetectable		 5jh7B-3r2tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 11 VAL A 122
ASP A 102
GLU A 162
TYR A  94
LEU A  86
 None
 1.15A 5jh7D-3r2tA:
undetectable		 5jh7D-3r2tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ASP A 169
ILE A 172
ARG A 173
LEU A 206
ASN A 226
 None
 0.83A 5k7uA-3r2tA:
undetectable		 5k7uA-3r2tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		3 / 3 LEU A 176
LEU A 206
ARG A 173
 None
 0.63A 6fgcA-3r2tA:
undetectable		 6fgcA-3r2tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		3 / 3 LEU A 176
LEU A 206
ARG A 173
 None
 0.62A 6fgdA-3r2tA:
undetectable		 6fgdA-3r2tA:
20.51