SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 12 LEU A 406
GLU A 235
LEU A 392
LEU A 395
PHE A 239
 None
 1.45A 1d4fD-3r38A:
undetectable		 1d4fD-3r38A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 11 ILE A 216
ALA A 196
ILE A 192
LEU A 159
PRO A 162
 None
 1.11A 1dg5A-3r38A:
undetectable		 1dg5A-3r38A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 12 ALA A 236
ILE A 252
LEU A 378
LEU A 267
LEU A 263
 None
 1.12A 1dtlA-3r38A:
undetectable		 1dtlA-3r38A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		4 / 5 GLY A 203
LEU A 222
THR A 223
VAL A 219
 None
 0.82A 1ekjF-3r38A:
undetectable
1ekjG-3r38A:
undetectable		 1ekjF-3r38A:
19.22
1ekjG-3r38A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		4 / 6 LEU A 426
GLU A 364
THR A 390
LEU A 429
 None
 1.24A 1etb2-3r38A:
undetectable		 1etb2-3r38A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 10 ASP A  50
LEU A  48
GLY A 398
TYR A  -5
LEU A 370
 None
None
None
None
CL  A 431 (-4.5A)
 1.40A 1sq5B-3r38A:
0.0		 1sq5B-3r38A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		4 / 6 ARG A 282
GLU A 276
PRO A 257
ALA A 255
 None
 1.36A 2ejfB-3r38A:
undetectable		 2ejfB-3r38A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		4 / 7 LEU A 152
VAL A 153
THR A 181
VAL A 157
 None
 1.06A 2zaxA-3r38A:
undetectable		 2zaxA-3r38A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 11 LEU A  58
ALA A  84
ASP A  83
ILE A  96
PRO A 101
 None
 1.13A 3spkA-3r38A:
undetectable		 3spkA-3r38A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		4 / 7 PHE A 198
ALA A  30
THR A  32
LEU A  42
 None
 0.93A 3t3sC-3r38A:
undetectable		 3t3sC-3r38A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 9 LEU A  58
ALA A  84
ASP A  83
ILE A  96
PRO A 101
 None
 1.02A 3u7sA-3r38A:
undetectable		 3u7sA-3r38A:
12.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		4 / 7 ALA A  94
ILE A  96
HIS A 127
GLY A 165
 None
None
None
SO4  A 433 (-3.7A)
 0.51A 3v4tH-3r38A:
55.6		 3v4tH-3r38A:
47.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 12 GLY A 380
ALA A 383
ILE A 377
VAL A   6
ILE A   4
 None
 0.99A 4ax8A-3r38A:
undetectable		 4ax8A-3r38A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 12 GLY A 380
ALA A 383
ILE A 377
VAL A   6
ILE A   4
 None
 0.95A 4aztA-3r38A:
undetectable		 4aztA-3r38A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 12 GLY A 380
ALA A 383
ILE A 377
VAL A   6
ILE A   4
 None
 0.95A 4azvA-3r38A:
undetectable		 4azvA-3r38A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		3 / 3 ASP A 194
LEU A 195
PHE A 198
 None
 0.68A 4pthA-3r38A:
undetectable		 4pthA-3r38A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		4 / 5 ARG A 105
MET A 202
GLU A 221
LEU A 176
 None
 1.42A 4v2oA-3r38A:
undetectable
4v2oC-3r38A:
undetectable		 4v2oA-3r38A:
12.06
4v2oC-3r38A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		4 / 7 GLU A 276
ILE A 260
ILE A 252
MET A 240
 None
 0.79A 4xumA-3r38A:
undetectable		 4xumA-3r38A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 12 LEU A  58
ALA A  84
ASP A  83
ILE A  96
PRO A 101
 None
 1.13A 6difA-3r38A:
undetectable		 6difA-3r38A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Listeria
monocytogenes) 		5 / 11 VAL A 312
ILE A 377
THR A 387
ALA A 383
LEU A 381
 None
 1.00A 6h1lB-3r38A:
undetectable		 6h1lB-3r38A:
22.99