SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8W_A_FLPA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	3r3c	4-HYDROXYBENZOYL-COA THIOESTERASE (Arthrobacter sp.)	6 / 12	VAL A 34 VAL A 109 LEU A 129 GLY A 65 ALA A 67 LEU A 56	None	1.41A	3n8wA-3r3cA: undetectable	3n8wA-3r3cA: 12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I8F_A_ML1A210_1 (PHENOLIC OXIDATIVE COUPLING PROTEIN)	3r3c	4-HYDROXYBENZOYL-COA THIOESTERASE (Arthrobacter sp.)	5 / 12	LEU A 129 VAL A 104 LEU A 56 VAL A 34 TYR A 26	None	1.49A	5i8fA-3r3cA: undetectable	5i8fA-3r3cA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_B_SAMB304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	3r3c	4-HYDROXYBENZOYL-COA THIOESTERASE (Arthrobacter sp.)	5 / 10	LEU A 15 GLY A 35 GLY A 32 LEU A 75 ALA A 48	None	1.02A	5l0zB-3r3cA: undetectable	5l0zB-3r3cA: 22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M24_A_9CRA501_1 (RETINOIC ACID RECEPTOR GAMMA)	3r3c	4-HYDROXYBENZOYL-COA THIOESTERASE (Arthrobacter sp.)	5 / 12	ALA A 111 LEU A 75 MET A 74 SER A 140 GLY A 13	None None 4CO A 152 (-4.2A) None None	1.10A	5m24A-3r3cA: undetectable	5m24A-3r3cA: 21.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3N8W_A_FLPA701_1","PROSTAGLANDIN G\/H SYNTHASE 1","3r3c","4-HYDROXYBENZOYL-COA THIOESTERASE","Arthrobacter sp.",6,"VAL A  34;VAL A 109;LEU A 129;GLY A  65;ALA A  67;LEU A  56","None","1.41A","3n8wA-3r3cA:undetectable","3n8wA-3r3cA:12.30"],["5I8F_A_ML1A210_1","PHENOLIC OXIDATIVE COUPLING PROTEIN","3r3c","4-HYDROXYBENZOYL-COA THIOESTERASE","Arthrobacter sp.",5,"LEU A 129;VAL A 104;LEU A  56;VAL A  34;TYR A  26","None","1.49A","5i8fA-3r3cA:undetectable","5i8fA-3r3cA:20.00"],["5L0Z_B_SAMB304_0","PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY","3r3c","4-HYDROXYBENZOYL-COA THIOESTERASE","Arthrobacter sp.",5,"LEU A  15;GLY A  35;GLY A  32;LEU A  75;ALA A  48","None","1.02A","5l0zB-3r3cA:undetectable","5l0zB-3r3cA:22.11"],["5M24_A_9CRA501_1","RETINOIC ACID RECEPTOR GAMMA","3r3c","4-HYDROXYBENZOYL-COA THIOESTERASE","Arthrobacter sp.",5,"ALA A 111;LEU A  75;MET A  74;SER A 140;GLY A  13","None;None;4CO A 152 (-4.2A);None;None","1.10A","5m24A-3r3cA:undetectable","5m24A-3r3cA:21.07"]]