SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r3g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 8 HIS B  57
ASP B 189
SER B 195
VAL B 213
GLY B 226
 None
 0.66A 1aq7A-3r3gB:
33.5		 1aq7A-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 8 HIS B  57
ASP B 189
VAL B 213
GLY B 216
GLY B 226
 None
 0.45A 1aq7A-3r3gB:
33.5		 1aq7A-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		7 / 9 ASP B 189
ALA B 190
SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 226
 None
 0.16A 1bcuH-3r3gB:
44.7		 1bcuH-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU B  99
ILE B 174
TRP B 215
GLU B 217
 None
 0.58A 1ditH-3r3gB:
44.2
1ditP-3r3gB:
undetectable		 1ditH-3r3gB:
97.68
1ditP-3r3gB:
4.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		6 / 9 HIS B  57
TYR B  60
ILE B 174
ASP B 189
GLU B 192
SER B 195
 None
 0.83A 1dwcH-3r3gB:
43.6		 1dwcH-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		7 / 9 HIS B  57
TYR B  60
ILE B 174
ASP B 189
SER B 195
TRP B 215
GLY B 226
 None
 0.39A 1dwcH-3r3gB:
43.6		 1dwcH-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 9 TYR B  60
TRP B  60
ILE B 174
ASP B 189
TRP B 215
 None
 0.83A 1dwcH-3r3gB:
43.6		 1dwcH-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		10 / 12 HIS B  57
TYR B  60
LEU B  99
ASP B 189
GLU B 192
SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 226
 None
 0.78A 1etrH-3r3gB:
43.5		 1etrH-3r3gB:
88.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		6 / 12 TYR B  60
TRP B  60
LEU B  99
ASP B 189
GLY B 216
GLY B 226
 None
 0.79A 1etrH-3r3gB:
43.5		 1etrH-3r3gB:
88.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 8 ASP B 189
SER B 195
VAL B 213
GLY B 216
GLY B 226
 None
 0.36A 1f5lA-3r3gB:
34.1		 1f5lA-3r3gB:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		4 / 6 ARG B 187
GLY B 223
ASP B 222
TYR B 225
 None
 1.44A 1kf6M-3r3gB:
undetectable
1kf6N-3r3gB:
undetectable		 1kf6M-3r3gB:
19.10
1kf6N-3r3gB:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 6 ASP B 189
SER B 195
VAL B 213
GLY B 216
GLY B 226
 None
 0.47A 1tnlA-3r3gB:
34.1		 1tnlA-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 11 HIS B  91
ARG B 101
TRP B 237
LYS B 240
VAL B 241
 None
 0.90A 2h9tH-3r3gB:
42.9		 2h9tH-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		6 / 11 HIS B  91
PRO B  92
ARG B  93
ARG B 101
TRP B 237
VAL B 241
 None
 0.86A 2h9tH-3r3gB:
42.9		 2h9tH-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 11 HIS B  91
PRO B  92
TRP B 237
VAL B 241
GLN B 244
 None
 0.83A 2h9tH-3r3gB:
42.9		 2h9tH-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 6 ASP B 189
SER B 195
VAL B 213
GLY B 216
GLY B 226
 None
 0.33A 2otvA-3r3gB:
34.2		 2otvA-3r3gB:
37.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		6 / 12 GLY B 142
GLY B 196
GLY B 193
THR B  54
LEU B  53
VAL B  31
 None
 1.31A 2oxtD-3r3gB:
undetectable		 2oxtD-3r3gB:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		8 / 12 ASP B 189
ALA B 190
SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 226
TYR B 228
 None
 0.32A 2p16A-3r3gB:
35.0		 2p16A-3r3gB:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ASP B 100
ASN B  98
THR B 172
 None
 0.75A 2q63B-3r3gB:
undetectable		 2q63B-3r3gB:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 8 ASP B 189
SER B 195
VAL B 213
GLY B 216
GLY B 226
 None
 0.45A 2vinA-3r3gB:
34.6		 2vinA-3r3gB:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		9 / 12 ASP B 189
ALA B 190
SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 219
GLY B 226
TYR B 228
 None
 0.38A 2w26A-3r3gB:
34.9		 2w26A-3r3gB:
40.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 11 HIS B  91
ARG B  93
ARG B 101
TRP B 237
LYS B 240
 None
 1.37A 3bf6H-3r3gB:
43.0		 3bf6H-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		6 / 11 HIS B  91
PRO B  92
ARG B  93
ARG B 101
TRP B 237
VAL B 241
 None
 0.90A 3bf6H-3r3gB:
43.0		 3bf6H-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		6 / 11 HIS B  91
PRO B  92
ARG B 101
TRP B 237
VAL B 241
GLN B 244
 None
 0.85A 3bf6H-3r3gB:
43.0		 3bf6H-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		7 / 11 HIS B  57
LEU B  99
ASP B 189
SER B 195
TRP B 215
GLY B 216
GLY B 226
 None
 0.48A 3gy3A-3r3gB:
32.8		 3gy3A-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 6 SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 226
 None
 0.35A 3rxfA-3r3gB:
13.5		 3rxfA-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		4 / 5 ASP B 189
SER B 195
VAL B 213
GLY B 226
 None
 0.53A 3rxhA-3r3gB:
34.0		 3rxhA-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		8 / 12 HIS B  57
TYR B  60
LEU B  99
ILE B 174
ASP B 189
GLU B 192
GLY B 216
GLY B 226
 None
 0.74A 4hfpB-3r3gB:
43.1		 4hfpB-3r3gB:
97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LYS B  60
ASP B 189
GLU B 192
GLY B 216
GLY B 226
 None
 0.96A 4hfpB-3r3gB:
43.1		 4hfpB-3r3gB:
97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		9 / 12 HIS B  57
TYR B  60
LEU B  99
ILE B 174
ALA B 190
GLU B 192
VAL B 213
TRP B 215
GLY B 226
 None
 0.80A 4hfpD-3r3gB:
43.1		 4hfpD-3r3gB:
97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		10 / 12 HIS B  57
TYR B  60
TRP B  60
LEU B  99
ILE B 174
ASP B 189
ALA B 190
VAL B 213
TRP B 215
GLY B 226
 None
 0.57A 4hfpD-3r3gB:
43.1		 4hfpD-3r3gB:
97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		5 / 10 HIS B  57
TYR B  60
LEU B  99
TRP B 215
GLY B 216
 None
 0.54A 4rn6A-3r3gB:
36.4		 4rn6A-3r3gB:
97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		8 / 12 HIS B  57
TYR B  60
LEU B  99
ALA B 190
VAL B 213
TRP B 215
GLY B 216
GLY B 226
 None
 0.77A 4rn6B-3r3gB:
36.6		 4rn6B-3r3gB:
97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		6 / 12 TYR B  60
TRP B  60
LEU B  99
TRP B 215
GLY B 216
GLY B 226
 None
 0.78A 4rn6B-3r3gB:
36.6		 4rn6B-3r3gB:
97.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens) 		6 / 12 GLY B 197
GLY B 211
VAL B 213
ALA B 190
LEU B 160
GLY B 136
 None
 1.39A 5hieC-3r3gB:
undetectable		 5hieC-3r3gB:
19.87