SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 ILE A 142
ALA A 144
LEU A  67
VAL A 217
LEU A 193
 None
 1.14A 1xdkA-3r3hA:
undetectable		 1xdkA-3r3hA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		7 / 12 GLY A  68
TYR A  73
SER A  74
ALA A 121
ALA A 144
ASP A 145
TYR A 152
 None
 0.90A 2avdA-3r3hA:
29.8		 2avdA-3r3hA:
40.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		6 / 12 GLY A  68
TYR A  73
ALA A 121
ASP A 143
ALA A 144
TYR A 152
 None
 0.76A 2avdB-3r3hA:
30.1		 2avdB-3r3hA:
40.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 ILE A 142
ALA A 144
LEU A  67
VAL A 217
LEU A 193
 None
 1.05A 3dzuA-3r3hA:
undetectable		 3dzuA-3r3hA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		4 / 6 LEU A 159
PHE A 137
ILE A  89
THR A 124
 None
 0.86A 3mdrA-3r3hA:
undetectable		 3mdrA-3r3hA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		4 / 6 PHE A 137
ILE A  89
ALA A 121
THR A 124
 None
 0.79A 3mdrB-3r3hA:
undetectable		 3mdrB-3r3hA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 9 LEU A 159
PHE A 137
ILE A  89
ALA A 121
THR A 124
 None
 0.75A 3mdtA-3r3hA:
undetectable		 3mdtA-3r3hA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 LEU A 159
PHE A 137
ILE A  89
ALA A 121
THR A 124
 None
 0.69A 3mdvB-3r3hA:
undetectable		 3mdvB-3r3hA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_TCWA227_1
(CATECHOL
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 10 MET A  42
ASP A 143
LYS A 146
ASP A 169
ASN A 170
 None
 0.72A 3s68A-3r3hA:
18.8		 3s68A-3r3hA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 10 LEU A 159
PHE A 137
ILE A  89
ALA A 121
THR A 124
 None
 0.79A 4j14A-3r3hA:
undetectable		 4j14A-3r3hA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PYL_A_TCWA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 10 MET A  42
ASP A 143
LYS A 146
ASP A 169
ASN A 170
 None
 0.65A 4pylA-3r3hA:
19.4		 4pylA-3r3hA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		6 / 12 GLY A  68
SER A  74
ALA A 121
ASP A 143
ALA A 144
TYR A 152
 None
 0.88A 4ymgB-3r3hA:
23.5		 4ymgB-3r3hA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 GLY A  68
TYR A  73
SER A  74
ALA A 121
TYR A 152
 None
 0.86A 4ymgB-3r3hA:
23.5		 4ymgB-3r3hA:
28.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		6 / 12 GLU A  66
TYR A  73
ALA A 121
ALA A 144
ASP A 145
TYR A 152
 None
 0.92A 5kvaA-3r3hA:
27.6		 5kvaA-3r3hA:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		7 / 12 GLY A  68
TYR A  73
ALA A 121
ASP A 143
ALA A 144
ASP A 145
TYR A 152
 None
 0.94A 5kvaA-3r3hA:
27.6		 5kvaA-3r3hA:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 MET A  42
GLU A  66
TYR A  73
ASP A 145
TYR A 152
 None
 0.93A 5kvaA-3r3hA:
27.6		 5kvaA-3r3hA:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		6 / 12 MET A  42
GLY A  68
TYR A  73
ASP A 143
ASP A 145
TYR A 152
 None
 0.87A 5kvaA-3r3hA:
27.6		 5kvaA-3r3hA:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 GLU A  66
TYR A  73
ALA A 121
ASP A 145
TYR A 152
 None
 0.80A 5kvaB-3r3hA:
27.5		 5kvaB-3r3hA:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		6 / 12 GLY A  68
TYR A  73
ALA A 121
ASP A 143
ASP A 145
TYR A 152
 None
 0.81A 5kvaB-3r3hA:
27.5		 5kvaB-3r3hA:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		6 / 12 MET A  42
GLU A  66
TYR A  73
ALA A 144
ASP A 145
TYR A 152
 None
 1.00A 5kvaB-3r3hA:
27.5		 5kvaB-3r3hA:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		7 / 12 MET A  42
GLY A  68
TYR A  73
ASP A 143
ALA A 144
ASP A 145
TYR A 152
 None
 0.97A 5kvaB-3r3hA:
27.5		 5kvaB-3r3hA:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		6 / 6 MET A  42
ASP A 143
LYS A 146
ASP A 169
ASN A 170
TRP A 173
 None
 0.66A 5logA-3r3hA:
30.5		 5logA-3r3hA:
46.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 GLY A  68
GLU A  95
ALA A 121
ALA A 144
TYR A 152
 None
 1.12A 5n5dA-3r3hA:
26.1		 5n5dA-3r3hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		7 / 12 VAL A  44
GLU A  66
TYR A  73
ALA A 121
PHE A 141
ALA A 144
TYR A 152
 None
 0.77A 5n5dA-3r3hA:
26.1		 5n5dA-3r3hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		7 / 12 VAL A  44
GLY A  68
TYR A  73
ALA A 121
PHE A 141
ALA A 144
TYR A 152
 None
 0.90A 5n5dA-3r3hA:
26.1		 5n5dA-3r3hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		7 / 12 VAL A  44
GLU A  66
TYR A  73
ALA A 121
PHE A 141
ALA A 144
TYR A 152
 None
 0.76A 5n5dB-3r3hA:
26.3		 5n5dB-3r3hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 PHE A 137
ILE A  89
ALA A 144
ILE A 168
ALA A 167
 None
 1.07A 5vceA-3r3hA:
undetectable		 5vceA-3r3hA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 GLY A  68
PRO A 120
GLY A 119
ASP A 169
ASP A  92
 None
 1.29A 5yn6A-3r3hA:
7.9		 5yn6A-3r3hA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 GLY A  68
PRO A 120
GLY A 119
ASP A 169
ASP A  92
 None
 1.30A 5yniA-3r3hA:
8.2		 5yniA-3r3hA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		5 / 12 GLY A  68
PRO A 120
GLY A 119
ASP A 169
ASP A  92
 None
 1.27A 5ynmA-3r3hA:
8.2		 5ynmA-3r3hA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT
(Legionella
pneumophila) 		3 / 3 LEU A 122
ASP A 143
ILE A 168
 None
 0.59A 6dh0B-3r3hA:
undetectable		 6dh0B-3r3hA:
16.59