SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 11 LEU A 156
GLY A 188
GLY A 154
ILE A 219
TYR A 218
 None
 1.05A 1p91A-3r3jA:
3.8		 1p91A-3r3jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 PHE A 279
ALA A 280
ILE A 427
CYH A 402
 None
 0.93A 1sbrA-3r3jA:
undetectable
1sbrB-3r3jA:
undetectable		 1sbrA-3r3jA:
17.03
1sbrB-3r3jA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 SER A 479
ASP A 487
SER A 486
GLN A 474
 None
 1.09A 2cmlB-3r3jA:
undetectable		 2cmlB-3r3jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 SER A 479
ASP A 487
SER A 486
GLN A 474
 None
 1.00A 2cmlD-3r3jA:
undetectable		 2cmlD-3r3jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 5 ASP A 461
LEU A 464
LYS A 463
MET A 468
 None
 1.01A 2gj5A-3r3jA:
undetectable		 2gj5A-3r3jA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 LEU A 164
VAL A 143
GLY A 171
ARG A 157
 None
 0.76A 2wd9A-3r3jA:
4.2		 2wd9A-3r3jA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 LEU A 164
VAL A 143
GLY A 171
ARG A 157
 None
 0.75A 2wd9B-3r3jA:
undetectable		 2wd9B-3r3jA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 VAL A 283
LEU A 180
GLY A 491
ALA A 492
 None
 0.95A 2xfsA-3r3jA:
undetectable		 2xfsA-3r3jA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 VAL A 283
LEU A 180
GLY A 491
ALA A 492
 None
 0.95A 2xh9A-3r3jA:
undetectable		 2xh9A-3r3jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 9 GLY A 187
GLN A 144
ILE A 115
VAL A 500
VAL A 148
 None
 1.42A 3fi0J-3r3jA:
undetectable		 3fi0J-3r3jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 9 PHE A  91
PHE A 172
PHE A 497
GLY A 496
PHE A 176
 None
 1.34A 3ko0A-3r3jA:
1.3
3ko0C-3r3jA:
0.0		 3ko0A-3r3jA:
14.88
3ko0C-3r3jA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 PHE A 497
GLY A 496
PHE A 176
PHE A 172
 None
 0.99A 3ko0D-3r3jA:
1.0
3ko0E-3r3jA:
1.2		 3ko0D-3r3jA:
14.88
3ko0E-3r3jA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 ARG A  74
GLU A  93
VAL A 489
ALA A 490
 None
 0.99A 4nkxA-3r3jA:
undetectable		 4nkxA-3r3jA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 TYR A 244
GLY A 220
PRO A 221
 None
 0.67A 4qwpA-3r3jA:
undetectable		 4qwpA-3r3jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 GLU A 331
TYR A 357
LEU A 354
PHE A 335
 None
 1.06A 4twdB-3r3jA:
undetectable
4twdC-3r3jA:
undetectable		 4twdB-3r3jA:
21.67
4twdC-3r3jA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 LEU A  73
ILE A  70
LEU A  95
GLU A  92
 None
 0.97A 4w5nA-3r3jA:
2.6		 4w5nA-3r3jA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 ASN A 349
TYR A 342
TYR A 357
LEU A 354
 None
 1.06A 4yv5A-3r3jA:
0.1		 4yv5A-3r3jA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 ASN A 349
TYR A 342
TYR A 357
LEU A 354
 None
 0.99A 4yv5B-3r3jA:
undetectable		 4yv5B-3r3jA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 9 LEU A 112
ILE A  70
ILE A 494
PHE A 497
VAL A 500
 None
 1.30A 5igzA-3r3jA:
undetectable		 5igzA-3r3jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3r3j GLUTAMATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 LEU A 340
HIS A 457
TYR A 274
GLU A 270
 None
 1.07A 6pahA-3r3jA:
undetectable		 6pahA-3r3jA:
20.50