SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 10 LEU A 148
HIS A 195
LEU A 196
ALA A 141
GLY A 240
 None
 1.43A 1cmcA-3r3sA:
undetectable
1cmcB-3r3sA:
undetectable		 1cmcA-3r3sA:
15.49
1cmcB-3r3sA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 SER A 186
LEU A 196
GLY A 230
PRO A 231
PHE A 250
 FMT  A 295 ( 2.5A)
None
NAD  A 300 (-4.7A)
NAD  A 300 (-4.9A)
None
 1.24A 1fdsA-3r3sA:
24.6		 1fdsA-3r3sA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 SER A 186
TYR A 199
GLY A 230
PRO A 231
PHE A 250
 FMT  A 295 ( 2.5A)
FMT  A 295 ( 4.2A)
NAD  A 300 (-4.7A)
NAD  A 300 (-4.9A)
None
 0.56A 1fdsA-3r3sA:
24.6		 1fdsA-3r3sA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 11 LEU A 148
HIS A 195
LEU A 196
ALA A 141
GLY A 240
 None
 1.34A 1mjqA-3r3sA:
undetectable
1mjqB-3r3sA:
undetectable		 1mjqA-3r3sA:
15.49
1mjqB-3r3sA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 10 LEU A 148
HIS A 195
LEU A 196
ALA A 141
GLY A 240
 None
 1.34A 1mjqC-3r3sA:
undetectable
1mjqD-3r3sA:
undetectable		 1mjqC-3r3sA:
15.49
1mjqD-3r3sA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 11 LEU A 148
HIS A 195
LEU A 196
ALA A 141
GLY A 240
 None
 1.36A 1mjqI-3r3sA:
undetectable
1mjqJ-3r3sA:
undetectable		 1mjqI-3r3sA:
15.49
1mjqJ-3r3sA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		3 / 3 TRP A 233
VAL A  33
PRO A  32
 None
 0.58A 1rg1A-3r3sA:
undetectable		 1rg1A-3r3sA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		3 / 3 TRP A 233
VAL A  33
PRO A  32
 None
 0.58A 1rh0A-3r3sA:
undetectable		 1rh0A-3r3sA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 LEU A 134
ALA A  77
LEU A 126
LEU A 175
ILE A 167
 None
 1.14A 1s9pA-3r3sA:
undetectable		 1s9pA-3r3sA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 11 TYR A 269
ILE A  61
ALA A  66
LEU A  53
ILE A  78
 None
NAD  A 300 (-3.7A)
None
None
None
 1.08A 1uduA-3r3sA:
undetectable		 1uduA-3r3sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 8 THR A 184
GLY A 137
THR A 202
ILE A 206
 NAD  A 300 ( 4.4A)
NAD  A 300 (-3.6A)
None
None
 0.88A 2f9wA-3r3sA:
1.8
2f9wB-3r3sA:
undetectable		 2f9wA-3r3sA:
25.70
2f9wB-3r3sA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 THR A 254
GLY A 251
PHE A 250
GLY A 230
ILE A 232
 None
None
None
NAD  A 300 (-4.7A)
NAD  A 300 (-4.3A)
 0.97A 2y7kC-3r3sA:
undetectable		 2y7kC-3r3sA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 5 PRO A 267
VAL A 268
THR A 254
GLY A 290
 None
 1.21A 3elzB-3r3sA:
undetectable		 3elzB-3r3sA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 GLU A  85
VAL A  76
ASP A  58
ILE A  78
ASN A  79
 None
None
MG  A 296 ( 2.5A)
None
NAD  A 300 ( 4.1A)
 1.46A 3jb3A-3r3sA:
4.0		 3jb3A-3r3sA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 LEU A  81
GLY A 107
ASP A 108
LEU A 109
ALA A 133
 NAD  A 300 (-4.3A)
None
NAD  A 300 (-3.6A)
NAD  A 300 (-3.9A)
None
 1.24A 3ou6C-3r3sA:
6.3		 3ou6C-3r3sA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 ALA A  68
THR A 184
ALA A 133
ILE A 131
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
 1.18A 3ut5B-3r3sA:
6.8		 3ut5B-3r3sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		3 / 3 GLU A  84
GLY A  25
SER A  59
 NAD  A 300 ( 2.8A)
None
MG  A 296 ( 2.1A)
 0.71A 4b53B-3r3sA:
undetectable		 4b53B-3r3sA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		6 / 12 ALA A  68
THR A 184
ALA A 133
ILE A 131
ALA A  52
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
None
 1.29A 4o2bD-3r3sA:
6.8		 4o2bD-3r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 9 SER A 239
GLY A  56
GLU A  84
ILE A  61
ALA A  65
 None
NAD  A 300 ( 3.7A)
NAD  A 300 ( 2.8A)
NAD  A 300 (-3.7A)
None
 1.39A 5entC-3r3sA:
undetectable		 5entC-3r3sA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 ALA A  68
THR A 184
ALA A 133
ALA A  52
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
 1.29A 5eypB-3r3sA:
6.7		 5eypB-3r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 ALA A  68
THR A 184
ALA A 133
ILE A 131
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
 1.13A 5eypB-3r3sA:
6.7		 5eypB-3r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 GLN A 242
PRO A  24
ALA A  23
LEU A 196
ILE A  61
 None
None
None
None
NAD  A 300 (-3.7A)
 1.23A 5hv1A-3r3sA:
undetectable		 5hv1A-3r3sA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		3 / 3 GLY A 240
GLN A 237
LYS A  20
 None
NAD  A 300 (-3.8A)
None
 0.73A 5imsB-3r3sA:
3.3		 5imsB-3r3sA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 ALA A  68
THR A 184
ALA A 133
ILE A 131
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
 1.07A 5nm5B-3r3sA:
7.1		 5nm5B-3r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 ALA A 266
PRO A 267
ILE A  67
ASP A  58
GLY A  56
 None
None
None
MG  A 296 ( 2.5A)
NAD  A 300 ( 3.7A)
 1.26A 5wwsB-3r3sA:
6.7		 5wwsB-3r3sA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 5 HIS A 292
HIS A 285
LEU A 265
VAL A 268
 None
 1.18A 6bc9A-3r3sA:
undetectable		 6bc9A-3r3sA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 GLY A  57
ILE A  61
ALA A  65
PRO A 262
CYH A  36
 None
NAD  A 300 (-3.7A)
None
None
None
 1.06A 6bq4B-3r3sA:
6.5		 6bq4B-3r3sA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 GLY A  99
VAL A  54
ARG A 100
VAL A  76
ASP A  75
 None
 1.34A 6bxlB-3r3sA:
2.3		 6bxlB-3r3sA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3r3s OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 6 LEU A 118
LEU A 129
THR A 168
ARG A 223
 None
 1.09A 6ew0G-3r3sA:
undetectable		 6ew0G-3r3sA:
13.59