SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 212
ALA A  81
GLY A  73
TYR A  72
PHE A  67
 None
 1.21A 1brpA-3r44A:
undetectable		 1brpA-3r44A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 6 ASN A   3
ALA A  75
GLY A  73
TYR A  72
 None
 1.00A 1c8lA-3r44A:
undetectable		 1c8lA-3r44A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 6 ASN A   3
ALA A  75
GLY A  73
TYR A  72
 None
 1.02A 1gfzA-3r44A:
undetectable		 1gfzA-3r44A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		5 / 11 ASN A   3
VAL A 151
THR A 213
ALA A 185
VAL A 181
 None
 1.20A 1rv7A-3r44A:
undetectable
1rv7B-3r44A:
undetectable		 1rv7A-3r44A:
10.44
1rv7B-3r44A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  78
ALA A  79
LEU A  77
LEU A  46
HIS A 178
 None
 1.42A 1y7iA-3r44A:
undetectable		 1y7iA-3r44A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 493
ALA A 477
ILE A 475
LYS A 490
 None
 0.95A 2othA-3r44A:
undetectable		 2othA-3r44A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  84
LEU A  60
ARG A  56
THR A 127
 None
 1.02A 3ag4N-3r44A:
undetectable
3ag4W-3r44A:
undetectable		 3ag4N-3r44A:
22.36
3ag4W-3r44A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 5 ASN A   3
ALA A  75
GLY A  73
TYR A  72
 None
 1.01A 3bcrA-3r44A:
undetectable		 3bcrA-3r44A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 5 PRO A 411
VAL A 409
THR A 463
GLY A 462
 None
 1.09A 3elzB-3r44A:
undetectable		 3elzB-3r44A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 8 THR A 329
GLY A 300
ALA A 325
ILE A 386
 None
 0.72A 3jusA-3r44A:
undetectable		 3jusA-3r44A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 8 THR A 329
GLY A 300
ALA A 325
ILE A 386
 None
 0.72A 3jusA-3r44A:
undetectable		 3jusA-3r44A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 231
ALA A 253
THR A 485
LEU A 286
 None
 0.95A 3khmA-3r44A:
undetectable		 3khmA-3r44A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 231
ALA A 253
THR A 485
LEU A 286
 None
 0.90A 3l4dA-3r44A:
undetectable		 3l4dA-3r44A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 231
ALA A 253
THR A 485
LEU A 286
 None
 0.88A 3l4dD-3r44A:
undetectable		 3l4dD-3r44A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 476
VAL A 452
ILE A 457
SER A 425
 None
 0.99A 3pglA-3r44A:
undetectable		 3pglA-3r44A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 290
TRP A 237
LEU A 201
MET A 228
 None
 1.41A 3uzzB-3r44A:
undetectable		 3uzzB-3r44A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 493
ALA A 477
ILE A 475
LYS A 490
 None
 0.91A 4eixA-3r44A:
undetectable		 4eixA-3r44A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 4 ILE A 343
VAL A 334
VAL A 352
ARG A 337
 None
 1.11A 4m6tA-3r44A:
undetectable		 4m6tA-3r44A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 430
GLY A 431
ILE A 440
ILE A 418
VAL A 445
 None
 1.14A 4nptA-3r44A:
undetectable		 4nptA-3r44A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 391
ARG A 320
LYS A 321
 None
 1.01A 4wq5B-3r44A:
undetectable		 4wq5B-3r44A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  78
ILE A 353
GLY A 308
THR A 213
HIS A 178
 None
 1.11A 4zdyA-3r44A:
undetectable		 4zdyA-3r44A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  78
ILE A 353
GLY A 308
THR A 213
HIS A 178
 None
 1.14A 4ze2A-3r44A:
undetectable		 4ze2A-3r44A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  78
ILE A 353
GLY A 308
THR A 213
HIS A 178
 None
 1.15A 5eslA-3r44A:
undetectable		 5eslA-3r44A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 5 PRO A 229
LEU A 141
TYR A  72
PHE A  71
 None
 1.37A 5igjA-3r44A:
undetectable		 5igjA-3r44A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 217
LEU A 202
GLY A 249
ILE A 192
 None
 1.01A 5ik1A-3r44A:
undetectable		 5ik1A-3r44A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)
(Mycobacterium
tuberculosis) 		5 / 12 MET A 258
VAL A 236
ILE A 295
LEU A 255
PHE A 272
 None
 1.27A 5im2A-3r44A:
1.2		 5im2A-3r44A:
22.86