SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 179
ILE A  62
ASN A 211
THR A 169
 None
None
SO4  A 260 (-3.3A)
SO4  A 262 (-3.8A)
 1.26A 1h7xA-3r4cA:
2.7		 1h7xA-3r4cA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 179
ILE A  62
ASN A 211
THR A 169
 None
None
SO4  A 260 (-3.3A)
SO4  A 262 (-3.8A)
 1.27A 1h7xC-3r4cA:
undetectable		 1h7xC-3r4cA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 179
ILE A  62
ASN A 211
THR A 169
 None
None
SO4  A 260 (-3.3A)
SO4  A 262 (-3.8A)
 1.27A 1h7xD-3r4cA:
2.5		 1h7xD-3r4cA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 100
PHE A 149
ILE A  82
ASN A 179
LEU A 166
 None
 1.07A 2w3bB-3r4cA:
undetectable		 2w3bB-3r4cA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 100
PHE A 149
ILE A  82
ASN A 179
LEU A 166
 None
 1.03A 2w3mA-3r4cA:
undetectable		 2w3mA-3r4cA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 143
VAL A  80
CYH A 145
 None
 1.05A 3fbxA-3r4cA:
undetectable		 3fbxA-3r4cA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)		 3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 MET A 160
GLU A 156
PHE A  97
PHE A  99
 None
 1.39A 3m0wB-3r4cA:
undetectable
3m0wJ-3r4cA:
undetectable		 3m0wB-3r4cA:
18.85
3m0wJ-3r4cA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A  25
VAL A  21
SER A  22
LEU A 248
THR A  12
 None
 1.46A 3mbhB-3r4cA:
3.5		 3mbhB-3r4cA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 216
LEU A  13
ILE A  39
THR A 240
ALA A 251
 None
 1.39A 5ienA-3r4cA:
undetectable		 5ienA-3r4cA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A   9
VAL A 243
GLY A 247
GLU A  52
VAL A  56
 SO4  A 260 (-3.7A)
None
None
None
None
 1.08A 6bqgA-3r4cA:
undetectable		 6bqgA-3r4cA:
16.06