SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3r4d SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 TYR B 258
LEU B  79
LEU B  97
PHE B 228
ILE B 104
 None
 1.21A 1mx8A-3r4dB:
undetectable		 1mx8A-3r4dB:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3r4d SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 5 PHE B 204
LEU B 195
PHE B 206
SER B 151
 None
 0.96A 1wrlC-3r4dB:
undetectable		 1wrlC-3r4dB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 3r4d SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 VAL B 140
GLY B 129
TYR B 137
TYR B 155
ILE B 235
 None
 1.42A 3bwyA-3r4dB:
undetectable		 3bwyA-3r4dB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3r4d SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 8 PHE B 204
ALA B 215
PHE B 206
ALA B 150
 None
 0.95A 3t3sD-3r4dB:
undetectable		 3t3sD-3r4dB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 3r4d CEA-RELATED CELL
ADHESION MOLECULE 1,
ISOFORM 1/2S
(Mus
musculus) 		3 / 3 ARG A  97
GLN A  99
GLU A   1
 None
 0.83A 4tvtA-3r4dA:
undetectable		 4tvtA-3r4dA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3r4d SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		3 / 3 ASP B 219
ASN B 198
PHE B 193
 None
 0.80A 5jglB-3r4dB:
undetectable		 5jglB-3r4dB:
22.91