SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 6 LEU A 148
ALA A 155
LEU A 149
THR A 152
 None
 0.97A 1ictB-3r4iA:
undetectable		 1ictB-3r4iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 7 THR A 114
SER A 172
SER A 221
VAL A 219
 None
 0.75A 2hdnE-3r4iA:
undetectable
2hdnF-3r4iA:
3.3
2hdnH-3r4iA:
3.2		 2hdnE-3r4iA:
8.08
2hdnF-3r4iA:
23.24
2hdnH-3r4iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 7 SER A 221
VAL A 219
THR A 114
SER A 172
 None
 0.74A 2hdnF-3r4iA:
3.3
2hdnG-3r4iA:
undetectable
2hdnH-3r4iA:
3.2		 2hdnF-3r4iA:
23.24
2hdnG-3r4iA:
8.08
2hdnH-3r4iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 6 THR A 114
SER A 172
SER A 221
VAL A 219
 None
 0.76A 2hdnI-3r4iA:
undetectable
2hdnJ-3r4iA:
2.8
2hdnL-3r4iA:
3.4		 2hdnI-3r4iA:
8.08
2hdnJ-3r4iA:
23.24
2hdnL-3r4iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 6 SER A 221
VAL A 219
THR A 114
SER A 172
 None
 0.78A 2hdnJ-3r4iA:
2.7
2hdnK-3r4iA:
undetectable
2hdnL-3r4iA:
3.1		 2hdnJ-3r4iA:
23.24
2hdnK-3r4iA:
8.08
2hdnL-3r4iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		5 / 12 ARG A 204
LEU A 201
ALA A 190
ASP A 188
ILE A 186
 None
 1.26A 2o4lA-3r4iA:
undetectable		 2o4lA-3r4iA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 5 VAL A  85
GLY A  84
TYR A  26
ASP A  24
 None
 1.28A 3w9tB-3r4iA:
undetectable		 3w9tB-3r4iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 5 VAL A  85
GLY A  84
TYR A  26
ASP A  24
 None
 1.27A 3w9tC-3r4iA:
undetectable		 3w9tC-3r4iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 5 VAL A  85
GLY A  84
TYR A  26
ASP A  24
 None
 1.28A 3w9tD-3r4iA:
undetectable		 3w9tD-3r4iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 5 VAL A  85
GLY A  84
TYR A  26
ASP A  24
 None
 1.28A 3w9tE-3r4iA:
undetectable		 3w9tE-3r4iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 5 VAL A  85
GLY A  84
TYR A  26
ASP A  24
 None
 1.29A 3w9tG-3r4iA:
undetectable		 3w9tG-3r4iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		3 / 4 SER A 307
GLY A 217
GLU A 169
 None
 0.60A 4juoA-3r4iA:
undetectable
4juoC-3r4iA:
undetectable		 4juoA-3r4iA:
19.42
4juoC-3r4iA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 309
ARG A 310
ALA A   3
ILE A 278
LEU A  10
 None
 1.21A 4l9qA-3r4iA:
undetectable		 4l9qA-3r4iA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		4 / 5 ILE A 261
VAL A 262
PHE A  80
HIS A 222
 None
 1.07A 4rzvA-3r4iA:
undetectable		 4rzvA-3r4iA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 3r4i CITRATE LYASE
(Paraburkholderia
xenovorans) 		5 / 12 ALA A  57
SER A  29
GLU A  30
LEU A  32
TYR A 112
 None
 1.48A 5vlmH-3r4iA:
undetectable		 5vlmH-3r4iA:
21.93