SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3r4k TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY
(Ruegeria
sp.
TM1040) 		4 / 7 MET A  41
ILE A  21
ARG A  18
GLY A  31
 None
 1.15A 2pnjB-3r4kA:
undetectable		 2pnjB-3r4kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3r4k TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY
(Ruegeria
sp.
TM1040) 		3 / 3 VAL A 179
VAL A 150
SER A 145
 None
 0.74A 3n8xB-3r4kA:
undetectable		 3n8xB-3r4kA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_1
(GLUTAMATE RECEPTOR 2)		 3r4k TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY
(Ruegeria
sp.
TM1040) 		5 / 9 SER A  82
LEU A 107
SER A 109
LEU A 110
ASP A 126
 None
 1.43A 3tkdA-3r4kA:
undetectable		 3tkdA-3r4kA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BCS_A_ACTA1126_0
(CHIMERIC AVIDIN)		 3r4k TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY
(Ruegeria
sp.
TM1040) 		4 / 4 THR A 223
GLN A 226
ARG A 228
THR A 229
 None
 1.17A 4bcsA-3r4kA:
undetectable		 4bcsA-3r4kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3r4k TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY
(Ruegeria
sp.
TM1040) 		4 / 6 SER A 197
ALA A 212
ALA A 136
SER A 137
 None
 0.81A 6bocA-3r4kA:
undetectable
6bocB-3r4kA:
undetectable
6bocC-3r4kA:
undetectable
6bocD-3r4kA:
undetectable		 6bocA-3r4kA:
6.15
6bocB-3r4kA:
6.15
6bocC-3r4kA:
6.15
6bocD-3r4kA:
6.15