SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		3 / 3 THR A  68
THR A  69
PRO A 424
 None
 0.80A 1a7yB-3r4tA:
undetectable		 1a7yB-3r4tA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 9 LEU A 443
ILE A 442
LEU A 358
GLY A 435
ALA A 402
 None
 1.26A 1e7aA-3r4tA:
undetectable		 1e7aA-3r4tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		4 / 7 VAL A  40
GLY A  16
THR A  12
ILE A  14
 None
 0.56A 1gtnC-3r4tA:
undetectable
1gtnD-3r4tA:
undetectable		 1gtnC-3r4tA:
10.89
1gtnD-3r4tA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		3 / 3 THR A  69
PRO A 424
THR A  68
 None
 0.86A 1i3wG-3r4tA:
undetectable		 1i3wG-3r4tA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		3 / 3 THR A  68
THR A  69
PRO A 424
 None
 0.84A 1qfiB-3r4tA:
undetectable		 1qfiB-3r4tA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		3 / 3 THR A  68
THR A  69
PRO A 424
 None
 0.85A 1unjF-3r4tA:
undetectable		 1unjF-3r4tA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 12 ALA A 290
GLY A 267
GLY A  62
LEU A 422
LEU A 410
 LLP  A 291 ( 2.7A)
None
None
None
None
 0.93A 2hw2A-3r4tA:
undetectable		 2hw2A-3r4tA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 12 PRO A 230
ALA A 220
LEU A 223
THR A 141
ILE A 260
 None
 1.17A 2jjpA-3r4tA:
undetectable		 2jjpA-3r4tA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		4 / 5 PRO A  75
ILE A  70
ARG A  76
ASP A 341
 None
 1.38A 2rhmB-3r4tA:
undetectable		 2rhmB-3r4tA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		4 / 5 PRO A  75
ILE A  70
ARG A  76
ASP A 341
 None
 1.34A 2rhmD-3r4tA:
undetectable		 2rhmD-3r4tA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		3 / 3 PHE A 237
SER A  63
LEU A  61
 None
 0.83A 2w1bA-3r4tA:
undetectable		 2w1bA-3r4tA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 12 LEU A 432
VAL A 407
GLY A 406
ILE A 442
LEU A 436
 None
 1.14A 3ijdB-3r4tA:
undetectable		 3ijdB-3r4tA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 9 VAL A 264
LEU A 159
ALA A 129
GLU A 131
THR A 157
 LLP  A 291 ( 4.3A)
None
None
None
None
 1.02A 3mdvA-3r4tA:
undetectable		 3mdvA-3r4tA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 12 ALA A 294
ILE A 111
LEU A 108
ALA A 333
VAL A 104
 None
 1.07A 3rukA-3r4tA:
undetectable		 3rukA-3r4tA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 11 GLY A 126
VAL A 130
GLU A 131
SER A 125
VAL A 264
 LLP  A 291 ( 3.5A)
None
None
LLP  A 291 ( 4.0A)
LLP  A 291 ( 4.3A)
 1.27A 4danA-3r4tA:
undetectable		 4danA-3r4tA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		4 / 7 GLU A 229
ARG A 372
GLY A 236
GLY A 233
 LLP  A 291 ( 3.8A)
None
None
None
 0.88A 4rdxA-3r4tA:
undetectable		 4rdxA-3r4tA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 12 ALA A 269
ILE A 427
SER A 428
ASP A 341
GLN A   6
 None
 1.26A 4rtpA-3r4tA:
2.1		 4rtpA-3r4tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 9 GLY A 296
ILE A 338
MET A 343
VAL A  77
THR A 334
 LLP  A 291 ( 4.9A)
None
None
None
None
 1.29A 4x3mA-3r4tA:
undetectable		 4x3mA-3r4tA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		4 / 6 GLU A 234
GLY A 272
ARG A 374
GLY A 375
 None
 0.97A 5cdpA-3r4tA:
undetectable
5cdpB-3r4tA:
undetectable		 5cdpA-3r4tA:
21.51
5cdpB-3r4tA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		3 / 3 THR A 320
HIS A  90
ASN A 324
 None
 0.72A 5n4tA-3r4tA:
undetectable		 5n4tA-3r4tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 12 LEU A 421
ILE A 378
THR A  69
LEU A 436
LEU A 353
 None
 0.99A 5nfjA-3r4tA:
undetectable		 5nfjA-3r4tA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		6 / 11 LEU A 421
ILE A 378
LEU A 436
SER A 433
LEU A 353
VAL A 354
 None
 1.08A 5twjD-3r4tA:
undetectable		 5twjD-3r4tA:
15.84