SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 236
VAL A 278
ILE A 284
GLY A 269
ILE A 262
 None
 1.01A 1ohrB-3r5bA:
undetectable		 1ohrB-3r5bA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 268
THR A 242
GLY A 237
GLY A 239
LEU A 261
 None
 1.08A 1rjdA-3r5bA:
undetectable		 1rjdA-3r5bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 268
THR A 242
GLY A 237
GLY A 239
LEU A 261
 None
 1.03A 1rjdC-3r5bA:
undetectable		 1rjdC-3r5bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		6 / 12 ILE A  37
ALA A  40
LEU A  45
LEU A  68
ALA A  67
LEU A   5
 None
 1.40A 1xlsA-3r5bA:
undetectable		 1xlsA-3r5bA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		6 / 12 ILE A  37
ALA A  40
LEU A  45
LEU A  68
ALA A  67
LEU A   5
 None
 1.39A 1xlsB-3r5bA:
undetectable		 1xlsB-3r5bA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		6 / 12 ILE A  37
ALA A  40
LEU A  45
LEU A  68
ALA A  67
LEU A   5
 None
 1.40A 1xlsC-3r5bA:
undetectable		 1xlsC-3r5bA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		6 / 12 ILE A  37
ALA A  40
LEU A  45
LEU A  68
ALA A  67
LEU A   5
 None
 1.39A 1xlsD-3r5bA:
undetectable		 1xlsD-3r5bA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 6 PHE A 170
LEU A 125
PRO A 100
ALA A 106
LEU A 131
 NPI  A 381 (-4.7A)
None
None
None
None
 1.39A 2vcvB-3r5bA:
undetectable		 2vcvB-3r5bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 6 PHE A 170
LEU A 125
PRO A 100
ALA A 106
LEU A 131
 NPI  A 381 (-4.7A)
None
None
None
None
 1.41A 2vcvK-3r5bA:
undetectable		 2vcvK-3r5bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 252
VAL A 228
GLY A 227
GLY A 244
 None
None
None
NPI  A 381 (-3.2A)
 0.79A 2wd9A-3r5bA:
undetectable		 2wd9A-3r5bA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 SER A 102
VAL A  24
TYR A  26
TRP A  21
 None
 1.21A 3bu1A-3r5bA:
undetectable		 3bu1A-3r5bA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  37
ALA A  40
LEU A  68
ALA A  67
LEU A   5
 None
 1.12A 3dzyA-3r5bA:
undetectable		 3dzyA-3r5bA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 189
VAL A 228
THR A 242
 None
 0.85A 3k4vA-3r5bA:
undetectable		 3k4vA-3r5bA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 259
ASP A 235
GLY A 263
THR A 242
 None
 1.10A 3k4vC-3r5bA:
undetectable		 3k4vC-3r5bA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 189
VAL A 228
THR A 242
 None
 0.78A 3ndtA-3r5bA:
undetectable		 3ndtA-3r5bA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 239
ARG A 223
GLY A 206
SER A 241
GLU A 279
 None
 1.39A 3tkaA-3r5bA:
undetectable		 3tkaA-3r5bA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 272
VAL A 290
VAL A 278
LEU A 282
VAL A 325
 None
 1.06A 3w68D-3r5bA:
undetectable		 3w68D-3r5bA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 128
LEU A 108
GLY A 193
PHE A 210
VAL A 123
 None
 1.19A 4fogC-3r5bA:
undetectable		 4fogC-3r5bA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 8 THR A  55
ALA A  53
THR A  92
VAL A  90
 None
 0.86A 4ik7B-3r5bA:
undetectable		 4ik7B-3r5bA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 128
LEU A 113
GLY A 193
PHE A 210
 None
 0.83A 4iqqB-3r5bA:
undetectable		 4iqqB-3r5bA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 128
LEU A 113
GLY A 193
PHE A 210
 None
 0.70A 4iqqC-3r5bA:
undetectable		 4iqqC-3r5bA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 103
ALA A  53
THR A  92
ALA A  91
 None
 1.01A 4qw0K-3r5bA:
undetectable		 4qw0K-3r5bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 103
ALA A  53
THR A  92
ALA A  91
 None
 1.02A 4qw0Y-3r5bA:
undetectable		 4qw0Y-3r5bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 125
ALA A  98
ILE A 128
GLY A 127
LEU A  94
 None
 0.99A 5nfjA-3r5bA:
undetectable		 5nfjA-3r5bA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 128
LEU A 113
GLY A 193
PHE A 210
 None
 0.87A 5nooA-3r5bA:
undetectable		 5nooA-3r5bA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 128
LEU A 113
GLY A 193
PHE A 210
 None
 0.84A 5nooB-3r5bA:
undetectable		 5nooB-3r5bA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 266
LEU A 282
VAL A 278
PHE A 316
ALA A 305
 None
 1.11A 6h1lA-3r5bA:
undetectable		 6h1lA-3r5bA:
20.31