SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		4 / 6 TRP A  15
ARG A 258
GLY A 100
ASP A 102
 None
 1.42A 1kf6M-3r5eA:
0.0
1kf6N-3r5eA:
undetectable		 1kf6M-3r5eA:
21.16
1kf6N-3r5eA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		5 / 12 ASP A 342
GLU A 339
ASP A 328
ALA A 330
ARG A 213
 None
 1.46A 1s14B-3r5eA:
undetectable		 1s14B-3r5eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		5 / 9 PRO A 141
THR A 143
PRO A 144
GLY A 145
SER A 146
 None
 1.13A 1urmA-3r5eA:
undetectable		 1urmA-3r5eA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		4 / 7 ILE A  62
TYR A  58
PHE A  48
ASP A  83
 None
 1.05A 2qebA-3r5eA:
0.7		 2qebA-3r5eA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		4 / 7 ILE A  62
TYR A  58
PHE A  48
ASP A  83
 None
 1.07A 2qebB-3r5eA:
undetectable		 2qebB-3r5eA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		3 / 3 TRP A  15
VAL A 174
ARG A 172
 None
 0.98A 3b0wA-3r5eA:
undetectable		 3b0wA-3r5eA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		3 / 3 ASP A 118
LEU A 121
GLN A 184
 None
 0.83A 3g4lA-3r5eA:
undetectable		 3g4lA-3r5eA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		3 / 3 PRO A 290
SER A 263
ASN A  44
 None
SO4  A 401 (-2.5A)
None
 0.86A 3lslG-3r5eA:
undetectable		 3lslG-3r5eA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		5 / 11 LEU A 329
PHE A 333
ILE A 210
ALA A 315
ALA A 229
 None
 1.05A 3mdtB-3r5eA:
undetectable		 3mdtB-3r5eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		3 / 3 ASP A  83
GLU A 108
SER A  26
 None
 0.75A 3p2kA-3r5eA:
1.8		 3p2kA-3r5eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		5 / 10 MET A  79
LEU A 352
ARG A 112
MET A  52
LEU A  65
 None
 1.23A 3uudB-3r5eA:
undetectable		 3uudB-3r5eA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A  47
ASP A  18
SER A  26
ASN A  28
GLN A  31
 None
 1.48A 4djfA-3r5eA:
8.5		 4djfA-3r5eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		4 / 7 ILE A 294
LEU A  16
ASP A  18
ASP A  17
 None
 1.07A 4mmcA-3r5eA:
undetectable		 4mmcA-3r5eA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3r5e TRANSALDOLASE
(Corynebacterium
glutamicum) 		5 / 9 ILE A 158
VAL A 109
THR A 120
ASP A 152
ILE A 140
 None
 1.43A 5lg3D-3r5eA:
undetectable		 5lg3D-3r5eA:
22.22