SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 270
GLY A 285
ASP A 286
PHE A 283
VAL A 282
 None
 1.11A 1ffyA-3r5gA:
undetectable		 1ffyA-3r5gA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 THR A 229
ILE A 304
GLY A 303
ILE A 332
ALA A 265
 None
 0.99A 1nv8B-3r5gA:
undetectable		 1nv8B-3r5gA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 MET A 330
ILE A 304
ILE A 264
TYR A 257
MET A 310
 None
 1.16A 1osvB-3r5gA:
undetectable		 1osvB-3r5gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.05A 1pxxC-3r5gA:
undetectable		 1pxxC-3r5gA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 270
GLY A 285
ASP A 286
PHE A 283
VAL A 282
 None
 1.11A 1qu2A-3r5gA:
undetectable		 1qu2A-3r5gA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 372
ILE A 374
THR A 229
THR A 334
 None
 0.86A 1sbrA-3r5gA:
3.6		 1sbrA-3r5gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 372
ILE A 374
THR A 229
THR A 334
 None
 0.86A 1sbrB-3r5gA:
3.9		 1sbrB-3r5gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 THR A 229
ILE A 304
GLY A 303
ILE A 332
ALA A 265
 None
 1.02A 1vq1B-3r5gA:
undetectable		 1vq1B-3r5gA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.07A 2aylB-3r5gA:
undetectable		 2aylB-3r5gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 268
ILE A 304
GLY A 416
VAL A 385
 None
 0.86A 3elzA-3r5gA:
undetectable		 3elzA-3r5gA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.10A 3n8xA-3r5gA:
undetectable		 3n8xA-3r5gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.06A 3n8yB-3r5gA:
undetectable		 3n8yB-3r5gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.05A 3n8zA-3r5gA:
2.3		 3n8zA-3r5gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.08A 3n8zB-3r5gA:
undetectable		 3n8zB-3r5gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.02A 4coxC-3r5gA:
undetectable		 4coxC-3r5gA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.05A 4otyA-3r5gA:
undetectable		 4otyA-3r5gA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.06A 4otyB-3r5gA:
undetectable		 4otyB-3r5gA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.11A 4rs0A-3r5gA:
undetectable		 4rs0A-3r5gA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.10A 5ikqA-3r5gA:
undetectable		 5ikqA-3r5gA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.08A 5ikqB-3r5gA:
undetectable		 5ikqB-3r5gA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.08A 5ikrB-3r5gA:
undetectable		 5ikrB-3r5gA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.10A 5jw1B-3r5gA:
undetectable		 5jw1B-3r5gA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 372
ILE A 332
VAL A 408
ILE A 382
ALA A 296
 None
 0.85A 5lg3A-3r5gA:
undetectable		 5lg3A-3r5gA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3r5g CYAB
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 372
ILE A 332
VAL A 408
ILE A 382
ALA A 296
 None
 0.82A 5lg3E-3r5gA:
2.2		 5lg3E-3r5gA:
21.65