SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 THR A  60
ALA A  58
ASP A 126
ILE A  68
LEU A 154
None
None
VBN  A   1 (-3.7A)
None
None
1.06A 1errA-3r5tA:
undetectable
1errA-3r5tA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 7 SER A  56
THR A  62
VAL A  61
ALA A  70
None
0.92A 1fo4B-3r5tA:
undetectable
1fo4B-3r5tA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 ILE A 123
GLY A 124
ALA A 125
HIS A 239
VBN  A   1 ( 4.8A)
VBN  A   1 (-3.3A)
VBN  A   1 (-3.4A)
VBN  A   1 (-4.1A)
0.90A 1wmqA-3r5tA:
undetectable
1wmqA-3r5tA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 ILE A 123
GLY A 124
ALA A 125
HIS A 239
VBN  A   1 ( 4.8A)
VBN  A   1 (-3.3A)
VBN  A   1 (-3.4A)
VBN  A   1 (-4.1A)
0.91A 1wmqB-3r5tA:
undetectable
1wmqB-3r5tA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 ILE A 123
GLY A 124
ALA A 125
HIS A 239
VBN  A   1 ( 4.8A)
VBN  A   1 (-3.3A)
VBN  A   1 (-3.4A)
VBN  A   1 (-4.1A)
0.90A 1wpuA-3r5tA:
undetectable
1wpuA-3r5tA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 ILE A 123
GLY A 124
ALA A 125
HIS A 239
VBN  A   1 ( 4.8A)
VBN  A   1 (-3.3A)
VBN  A   1 (-3.4A)
VBN  A   1 (-4.1A)
0.90A 1wpuB-3r5tA:
undetectable
1wpuB-3r5tA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 ILE A 123
GLY A 124
ALA A 125
HIS A 239
VBN  A   1 ( 4.8A)
VBN  A   1 (-3.3A)
VBN  A   1 (-3.4A)
VBN  A   1 (-4.1A)
0.97A 1wrqA-3r5tA:
undetectable
1wrqA-3r5tA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 ILE A 123
GLY A 124
ALA A 125
HIS A 239
VBN  A   1 ( 4.8A)
VBN  A   1 (-3.3A)
VBN  A   1 (-3.4A)
VBN  A   1 (-4.1A)
0.95A 1wrqB-3r5tA:
undetectable
1wrqB-3r5tA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 10 THR A 257
GLU A 226
GLY A 191
ILE A 195
LEU A 225
None
1.10A 1x7pA-3r5tA:
2.5
1x7pB-3r5tA:
2.4
1x7pA-3r5tA:
25.00
1x7pB-3r5tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 5 ILE A 307
SER A 321
LEU A 311
ASN A 308
None
1.08A 1y0xX-3r5tA:
undetectable
1y0xX-3r5tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 4 ARG A 240
ASP A 241
LEU A 154
ARG A 129
None
VBN  A   1 ( 4.2A)
None
None
1.21A 2ziaB-3r5tA:
2.5
2ziaB-3r5tA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 8 SER A  56
THR A  62
VAL A  61
ALA A  70
None
0.92A 3ax7A-3r5tA:
undetectable
3ax7A-3r5tA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 8 SER A  56
THR A  62
VAL A  61
ALA A  70
None
0.85A 3ax9A-3r5tA:
undetectable
3ax9A-3r5tA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 5 GLN A 157
ILE A  68
LEU A 158
PHE A  37
MOH  A   3 ( 2.6A)
None
None
EDO  A   4 (-4.0A)
1.21A 3ls4L-3r5tA:
undetectable
3ls4L-3r5tA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
3 / 3 SER A 236
GLY A 235
GLN A 233
None
0.42A 3v4tH-3r5tA:
undetectable
3v4tH-3r5tA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 ILE A 132
VAL A 119
SER A  43
ASP A 116
None
1.14A 4iaqA-3r5tA:
undetectable
4iaqA-3r5tA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 LEU A  65
ILE A 142
THR A 162
GLY A 159
None
0.93A 4l39A-3r5tA:
undetectable
4l39A-3r5tA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 7 LEU A  65
ILE A 142
THR A 162
GLY A 159
None
0.91A 4l39B-3r5tA:
undetectable
4l39B-3r5tA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
3 / 3 PHE A 259
THR A 179
LEU A 188
None
0.77A 4qztA-3r5tA:
undetectable
4qztA-3r5tA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 GLU A 176
THR A 179
GLN A 152
LEU A 300
None
1.13A 4qzuC-3r5tA:
undetectable
4qzuC-3r5tA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 THR A  60
ALA A  58
ASP A 126
ILE A  68
LEU A 154
None
None
VBN  A   1 (-3.7A)
None
None
0.89A 4xi3B-3r5tA:
undetectable
4xi3B-3r5tA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 ASP A 274
ALA A 255
ASN A 194
VAL A 196
TYR A 198
None
1.44A 5kbwB-3r5tA:
undetectable
5kbwB-3r5tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 10 VAL A 288
ILE A 283
TYR A 247
ALA A 268
PHE A 271
None
1.19A 5mxbA-3r5tA:
undetectable
5mxbA-3r5tA:
13.85