SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		4 / 7 ALA A 270
LEU A 272
SER A 183
THR A 268
 None
 1.02A 1dvxA-3r5xA:
undetectable		 1dvxA-3r5xA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 12 PHE A  55
GLY A   4
LEU A  60
LEU A  74
LEU A 288
 None
 1.02A 1zgyA-3r5xA:
undetectable		 1zgyA-3r5xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		4 / 7 ALA A 199
TYR A 208
ARG A 196
TYR A 204
 None
 1.17A 2ajvH-3r5xA:
undetectable
2ajvL-3r5xA:
undetectable		 2ajvH-3r5xA:
19.61
2ajvL-3r5xA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 12 LEU A 220
ASN A 229
VAL A 217
THR A 181
ILE A 180
 None
 1.23A 3bf1A-3r5xA:
undetectable
3bf1B-3r5xA:
undetectable		 3bf1A-3r5xA:
21.12
3bf1B-3r5xA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 11 ASP A 151
LEU A 126
PHE A 123
LEU A 155
ILE A 156
 None
 1.44A 3o94A-3r5xA:
2.0		 3o94A-3r5xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 11 ASP A 151
LEU A 126
PHE A 123
LEU A 155
ILE A 156
 None
 1.45A 3o94C-3r5xA:
undetectable		 3o94C-3r5xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 11 ASP A 151
LEU A 126
PHE A 123
LEU A 155
ILE A 156
 None
 1.44A 3o94D-3r5xA:
undetectable		 3o94D-3r5xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		4 / 8 VAL A  70
LEU A  58
LEU A  60
ILE A  38
 None
 0.80A 3u5kD-3r5xA:
undetectable		 3u5kD-3r5xA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		4 / 5 TYR A  81
GLY A  68
ASP A  67
VAL A  16
 None
 1.03A 4nkvD-3r5xA:
undetectable		 4nkvD-3r5xA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 12 LEU A  58
LEU A  74
ALA A  50
ILE A  38
ILE A  53
 None
 1.06A 4o2bB-3r5xA:
undetectable		 4o2bB-3r5xA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		3 / 3 ASP A 127
LEU A 126
PHE A 123
 None
 0.71A 4pthA-3r5xA:
3.2		 4pthA-3r5xA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		4 / 6 ARG A 246
GLY A 266
SER A 271
LEU A 272
 None
 0.59A 5bphA-3r5xA:
33.3		 5bphA-3r5xA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		4 / 7 ARG A 246
GLY A 266
SER A 271
LEU A 272
 None
 0.27A 5bphB-3r5xA:
32.9		 5bphB-3r5xA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		4 / 6 ARG A 246
GLY A 266
SER A 271
LEU A 272
 None
 0.25A 5bphD-3r5xA:
15.2		 5bphD-3r5xA:
37.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		3 / 3 TYR A  33
TYR A 244
SER A  82
 None
 0.90A 5iktB-3r5xA:
undetectable		 5iktB-3r5xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		3 / 3 TYR A  33
TYR A 244
SER A 295
 None
 0.90A 5iktB-3r5xA:
undetectable		 5iktB-3r5xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 12 ILE A 292
PRO A  80
LEU A 296
PHE A  55
GLY A   4
 None
 1.12A 5l6eA-3r5xA:
undetectable		 5l6eA-3r5xA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 12 LEU A  58
LEU A  74
ALA A  50
ILE A  38
ILE A  53
 None
 1.02A 5mioB-3r5xA:
undetectable		 5mioB-3r5xA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 9 LEU A  74
ILE A  79
GLY A  78
LEU A  46
ALA A  50
 None
 0.86A 5o96A-3r5xA:
undetectable
5o96B-3r5xA:
undetectable		 5o96A-3r5xA:
21.07
5o96B-3r5xA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 12 LEU A  28
ASP A  29
ILE A   3
SER A 285
LEU A 288
 None
 1.15A 5twjC-3r5xA:
undetectable		 5twjC-3r5xA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3r5x D-ALANINE--D-ALANINE
LIGASE
(Bacillus
anthracis) 		5 / 12 GLY A  90
GLY A  65
GLY A  68
HIS A  61
VAL A  10
 None
 0.93A 5vimB-3r5xA:
undetectable		 5vimB-3r5xA:
21.50