SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NV8_B_SAMB301_0 (HEMK PROTEIN)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 12	THR A 315 ILE A 271 GLY A 254 GLY A 252 ILE A 246	None None EDO A 3 (-3.5A) CL A 9 ( 3.4A) None	0.99A	1nv8B-3r68A: undetectable	1nv8B-3r68A: 17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SG9_B_SAMB302_0 (HEMK PROTEIN)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 12	THR A 315 ILE A 271 GLY A 254 GLY A 252 ILE A 246	None None EDO A 3 (-3.5A) CL A 9 ( 3.4A) None	1.01A	1sg9B-3r68A: undetectable	1sg9B-3r68A: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VQ1_B_SAMB301_0 (N5-GLUTAMINE METHYLTRANSFERASE, HEMK)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 12	THR A 315 ILE A 271 GLY A 254 GLY A 252 ILE A 246	None None EDO A 3 (-3.5A) CL A 9 ( 3.4A) None	1.00A	1vq1B-3r68A: undetectable	1vq1B-3r68A: 17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_A_TRPA1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 9	GLY A 303 HIS A 301 ILE A 308 VAL A 291 VAL A 296	None ZN A 7 ( 3.2A) None None None	1.11A	3fi0A-3r68A: undetectable	3fi0A-3r68A: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_C_TRPC1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 9	GLY A 303 HIS A 301 ILE A 308 VAL A 291 VAL A 296	None ZN A 7 ( 3.2A) None None None	1.11A	3fi0C-3r68A: undetectable	3fi0C-3r68A: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_D_TRPD1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 9	GLY A 303 HIS A 301 ILE A 308 VAL A 291 VAL A 296	None ZN A 7 ( 3.2A) None None None	1.10A	3fi0D-3r68A: undetectable	3fi0D-3r68A: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_F_TRPF1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 9	GLY A 303 HIS A 301 ILE A 308 VAL A 291 VAL A 296	None ZN A 7 ( 3.2A) None None None	1.13A	3fi0F-3r68A: undetectable	3fi0F-3r68A: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_J_TRPJ1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 9	GLY A 303 HIS A 301 ILE A 308 VAL A 291 VAL A 296	None ZN A 7 ( 3.2A) None None None	1.10A	3fi0J-3r68A: undetectable	3fi0J-3r68A: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_K_TRPK1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 9	GLY A 303 HIS A 301 ILE A 308 VAL A 291 VAL A 296	None ZN A 7 ( 3.2A) None None None	1.16A	3fi0K-3r68A: undetectable	3fi0K-3r68A: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_N_TRPN1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 9	GLY A 303 HIS A 301 ILE A 308 VAL A 291 VAL A 296	None ZN A 7 ( 3.2A) None None None	1.09A	3fi0N-3r68A: undetectable	3fi0N-3r68A: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_O_TRPO1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 9	GLY A 303 HIS A 301 ILE A 308 VAL A 291 VAL A 296	None ZN A 7 ( 3.2A) None None None	1.12A	3fi0O-3r68A: undetectable	3fi0O-3r68A: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_R_TRPR1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	3r68	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3 (Mus musculus)	5 / 9	GLY A 303 HIS A 301 ILE A 308 VAL A 291 VAL A 296	None ZN A 7 ( 3.2A) None None None	1.08A	3fi0R-3r68A: undetectable	3fi0R-3r68A: 16.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NV8_B_SAMB301_0","HEMK PROTEIN","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"THR A 315;ILE A 271;GLY A 254;GLY A 252;ILE A 246","None;None;EDO A   3 (-3.5A); CL A   9 ( 3.4A);None","0.99A","1nv8B-3r68A:undetectable","1nv8B-3r68A:17.61"],["1SG9_B_SAMB302_0","HEMK PROTEIN","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"THR A 315;ILE A 271;GLY A 254;GLY A 252;ILE A 246","None;None;EDO A   3 (-3.5A); CL A   9 ( 3.4A);None","1.01A","1sg9B-3r68A:undetectable","1sg9B-3r68A:18.25"],["1VQ1_B_SAMB301_0","N5-GLUTAMINE METHYLTRANSFERASE, HEMK","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"THR A 315;ILE A 271;GLY A 254;GLY A 252;ILE A 246","None;None;EDO A   3 (-3.5A); CL A   9 ( 3.4A);None","1.00A","1vq1B-3r68A:undetectable","1vq1B-3r68A:17.41"],["3FI0_A_TRPA1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"GLY A 303;HIS A 301;ILE A 308;VAL A 291;VAL A 296","None; ZN A   7 ( 3.2A);None;None;None","1.11A","3fi0A-3r68A:undetectable","3fi0A-3r68A:16.56"],["3FI0_C_TRPC1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"GLY A 303;HIS A 301;ILE A 308;VAL A 291;VAL A 296","None; ZN A   7 ( 3.2A);None;None;None","1.11A","3fi0C-3r68A:undetectable","3fi0C-3r68A:16.56"],["3FI0_D_TRPD1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"GLY A 303;HIS A 301;ILE A 308;VAL A 291;VAL A 296","None; ZN A   7 ( 3.2A);None;None;None","1.10A","3fi0D-3r68A:undetectable","3fi0D-3r68A:16.56"],["3FI0_F_TRPF1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"GLY A 303;HIS A 301;ILE A 308;VAL A 291;VAL A 296","None; ZN A   7 ( 3.2A);None;None;None","1.13A","3fi0F-3r68A:undetectable","3fi0F-3r68A:16.56"],["3FI0_J_TRPJ1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"GLY A 303;HIS A 301;ILE A 308;VAL A 291;VAL A 296","None; ZN A   7 ( 3.2A);None;None;None","1.10A","3fi0J-3r68A:undetectable","3fi0J-3r68A:16.56"],["3FI0_K_TRPK1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"GLY A 303;HIS A 301;ILE A 308;VAL A 291;VAL A 296","None; ZN A   7 ( 3.2A);None;None;None","1.16A","3fi0K-3r68A:undetectable","3fi0K-3r68A:16.56"],["3FI0_N_TRPN1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"GLY A 303;HIS A 301;ILE A 308;VAL A 291;VAL A 296","None; ZN A   7 ( 3.2A);None;None;None","1.09A","3fi0N-3r68A:undetectable","3fi0N-3r68A:16.56"],["3FI0_O_TRPO1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"GLY A 303;HIS A 301;ILE A 308;VAL A 291;VAL A 296","None; ZN A   7 ( 3.2A);None;None;None","1.12A","3fi0O-3r68A:undetectable","3fi0O-3r68A:16.56"],["3FI0_R_TRPR1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","3r68","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3","Mus musculus",5,"GLY A 303;HIS A 301;ILE A 308;VAL A 291;VAL A 296","None; ZN A   7 ( 3.2A);None;None;None","1.08A","3fi0R-3r68A:undetectable","3fi0R-3r68A:16.56"]]