SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		4 / 8 ASP A  20
ASN A  54
GLY A 102
GLY A  61
 None
 0.82A 1jr1B-3r6hA:
undetectable		 1jr1B-3r6hA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 10 ARG A 148
ALA A 140
GLY A  81
GLY A  82
ILE A 218
 None
 0.95A 1sdvA-3r6hA:
undetectable		 1sdvA-3r6hA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 11 GLY A 221
GLY A 224
ILE A 137
MET A 135
ALA A 141
 None
None
None
K  A 300 (-4.8A)
None
 1.03A 1x7pA-3r6hA:
undetectable
1x7pB-3r6hA:
undetectable		 1x7pA-3r6hA:
23.15
1x7pB-3r6hA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		4 / 4 LEU A  34
SER A  59
LEU A  89
LEU A  85
 None
 1.03A 1yajA-3r6hA:
undetectable		 1yajA-3r6hA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		4 / 5 LEU A  34
SER A  59
LEU A  89
LEU A  85
 None
 1.05A 1yajD-3r6hA:
undetectable		 1yajD-3r6hA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		4 / 4 VAL A 144
LEU A  49
ILE A  38
LEU A  34
 None
 1.02A 2byoA-3r6hA:
undetectable		 2byoA-3r6hA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 12 ARG A 148
ALA A 140
GLY A  81
GLY A  82
ILE A 218
 None
 0.82A 2fxeA-3r6hA:
undetectable		 2fxeA-3r6hA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		4 / 5 LEU A  79
GLY A  82
ILE A 222
ILE A 225
 None
 0.80A 2q9rA-3r6hA:
undetectable		 2q9rA-3r6hA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 12 PHE A 174
LEU A 112
ALA A 109
SER A 114
GLY A 159
 None
 0.92A 4dm8B-3r6hA:
undetectable		 4dm8B-3r6hA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 12 ILE A 137
ALA A 106
PHE A  83
GLY A  61
PHE A  62
 None
 0.87A 4ls7A-3r6hA:
undetectable
4ls7B-3r6hA:
undetectable		 4ls7A-3r6hA:
22.99
4ls7B-3r6hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 12 LEU A  79
GLY A  82
GLN A  31
ILE A 137
PHE A 110
 None
 1.40A 4udcA-3r6hA:
undetectable		 4udcA-3r6hA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 12 GLY A  81
GLY A  82
MET A 107
ILE A 225
ILE A 218
 None
 1.07A 4zvmA-3r6hA:
undetectable
4zvmB-3r6hA:
undetectable		 4zvmA-3r6hA:
22.05
4zvmB-3r6hA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 12 TYR A 154
ILE A  76
PHE A  62
VAL A 131
GLY A  81
 None
 1.06A 5esgA-3r6hA:
undetectable		 5esgA-3r6hA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 12 PHE A 174
ALA A 109
MET A 142
SER A 114
GLY A 159
 None
 0.85A 5m24A-3r6hA:
undetectable		 5m24A-3r6hA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 12 ILE A 178
VAL A  50
VAL A  96
SER A 186
GLU A 182
 None
 1.12A 6bzoC-3r6hA:
undetectable		 6bzoC-3r6hA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		5 / 12 LEU A  34
THR A 101
ALA A  41
LEU A 185
LEU A  49
 None
 1.22A 6ie8A-3r6hA:
undetectable		 6ie8A-3r6hA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3r6h ENOYL-COA HYDRATASE,
ECHA3
(Mycobacterium
marinum) 		3 / 3 ARG A 118
PHE A  83
PHE A 174
 None
 1.09A 6nknC-3r6hA:
undetectable
6nknJ-3r6hA:
undetectable		 6nknC-3r6hA:
21.40
6nknJ-3r6hA:
15.53