SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		5 / 11 ILE A 453
PHE A 429
LEU A 229
PRO A 230
ILE A 492
 None
None
None
EDO  A 527 ( 4.8A)
None
 0.99A 1dg5A-3r6kA:
undetectable		 1dg5A-3r6kA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		5 / 12 ALA A 484
ILE A 470
MET A 525
LEU A 249
PHE A 429
 None
 1.02A 1dtlA-3r6kA:
undetectable		 1dtlA-3r6kA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		3 / 3 PRO A 422
THR A 420
PRO A 419
 None
 0.80A 2d55C-3r6kA:
undetectable		 2d55C-3r6kA:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		5 / 12 LEU A 249
LEU A 237
ILE A 453
GLY A 264
LEU A 447
 None
 1.20A 2j7xA-3r6kA:
undetectable		 2j7xA-3r6kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		3 / 3 ASN A 474
MET A 525
PHE A 472
 None
 0.86A 3g4lD-3r6kA:
undetectable		 3g4lD-3r6kA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		5 / 12 LEU A 249
LEU A 237
ILE A 453
GLY A 264
LEU A 447
 None
 1.22A 4j26A-3r6kA:
undetectable		 4j26A-3r6kA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		5 / 12 ILE A 453
PHE A 429
LEU A 229
PRO A 230
ILE A 492
 None
None
None
EDO  A 527 ( 4.8A)
None
 0.95A 4m2xA-3r6kA:
undetectable		 4m2xA-3r6kA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		5 / 12 LEU A 400
GLN A 262
VAL A 319
ILE A 366
VAL A 305
 None
 1.36A 4okwA-3r6kA:
undetectable		 4okwA-3r6kA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		4 / 5 PHE A 333
PRO A 386
VAL A 387
PHE A 242
 None
 1.24A 4w5oA-3r6kA:
undetectable		 4w5oA-3r6kA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		4 / 5 PHE A 333
PRO A 386
VAL A 387
PHE A 242
 None
 1.23A 4z4cA-3r6kA:
undetectable		 4z4cA-3r6kA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		4 / 5 PHE A 333
PRO A 386
VAL A 387
PHE A 242
 None
 1.26A 4z4dA-3r6kA:
undetectable		 4z4dA-3r6kA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		5 / 12 GLY A 490
LEU A 249
PHE A 472
GLY A 508
LEU A 237
 None
 1.29A 4ze1A-3r6kA:
undetectable		 4ze1A-3r6kA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		4 / 4 VAL A 376
ILE A 368
ASN A 291
VAL A 294
 None
 1.31A 5ajqA-3r6kA:
undetectable		 5ajqA-3r6kA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3r6k VP1 PROTEIN
(Norwalk
virus) 		4 / 7 SER A 463
ALA A 267
ILE A 453
LEU A 448
 None
 0.75A 5te8A-3r6kA:
undetectable		 5te8A-3r6kA:
19.79