SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 6 GLU A 293
TYR A 296
GLN A 318
ASP A 369
 None
None
DTT  A   3 (-3.6A)
None
 1.34A 2cl5B-3r6nA:
undetectable		 2cl5B-3r6nA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 HIS A 551
SER A 546
SER A 597
PHE A 600
 None
 1.14A 2obvA-3r6nA:
undetectable		 2obvA-3r6nA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 SER A 546
SER A 597
PHE A 600
ASP A 406
 None
 1.10A 2obvA-3r6nA:
undetectable		 2obvA-3r6nA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 THR A 613
GLN A 609
ASP A 614
SER A 610
 None
 1.18A 2xz5A-3r6nA:
undetectable
2xz5C-3r6nA:
undetectable		 2xz5A-3r6nA:
17.87
2xz5C-3r6nA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 THR A 613
GLN A 609
ASP A 614
SER A 610
 None
 1.19A 2xz5C-3r6nA:
undetectable
2xz5D-3r6nA:
undetectable		 2xz5C-3r6nA:
17.87
2xz5D-3r6nA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 6 GLU A 293
TYR A 296
GLN A 318
ASP A 369
 None
None
DTT  A   3 (-3.6A)
None
 1.36A 2zvjA-3r6nA:
undetectable		 2zvjA-3r6nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 6 LEU A 251
TYR A 255
LEU A 258
LEU A 235
 None
 0.90A 3f33A-3r6nA:
4.8		 3f33A-3r6nA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		3 / 3 ASP A 480
LEU A 510
VAL A 370
 None
 0.56A 4jecB-3r6nA:
undetectable		 4jecB-3r6nA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 HIS A 551
SER A 546
SER A 597
PHE A 600
 None
 1.21A 4kttC-3r6nA:
undetectable		 4kttC-3r6nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 SER A 546
SER A 597
PHE A 600
ASP A 406
 None
 1.11A 4kttC-3r6nA:
undetectable		 4kttC-3r6nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 5 SER A 262
ALA A 261
HIS A 225
LEU A 259
 None
 1.41A 5dzkb-3r6nA:
undetectable
5dzkp-3r6nA:
undetectable		 5dzkb-3r6nA:
18.48
5dzkp-3r6nA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 5 SER A 262
ALA A 261
HIS A 225
LEU A 259
 None
 1.43A 5dzkc-3r6nA:
undetectable
5dzkq-3r6nA:
undetectable		 5dzkc-3r6nA:
18.48
5dzkq-3r6nA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 LEU A 536
TRP A 537
LEU A 540
MET A 544
 None
 0.94A 5hs6A-3r6nA:
undetectable		 5hs6A-3r6nA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 5 TYR A 378
SER A 442
ALA A 519
GLN A 386
 None
 1.30A 5n4iA-3r6nA:
undetectable		 5n4iA-3r6nA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 HIS A 551
SER A 546
SER A 597
PHE A 600
 None
 1.21A 6fbnB-3r6nA:
undetectable		 6fbnB-3r6nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 SER A 546
SER A 597
PHE A 600
ASP A 406
 None
 1.10A 6fbnB-3r6nA:
undetectable		 6fbnB-3r6nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 HIS A 551
SER A 546
SER A 597
PHE A 600
 None
 1.21A 6fcbA-3r6nA:
undetectable		 6fcbA-3r6nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3r6n DESMOPLAKIN
(Homo
sapiens) 		4 / 8 SER A 546
SER A 597
PHE A 600
ASP A 406
 None
 1.14A 6fcbA-3r6nA:
undetectable		 6fcbA-3r6nA:
21.58