SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 8 GLY A  84
VAL A  81
GLU A  80
ILE A  46
 GLY  A  84 ( 0.0A)
VAL  A  81 ( 0.6A)
GLU  A  80 ( 0.6A)
ILE  A  46 ( 0.7A)
 0.85A 1pk7B-3r6yA:
undetectable		 1pk7B-3r6yA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 6 ASN A 368
ILE A 375
GLN A 371
THR A  37
 ASN  A 368 ( 0.6A)
ILE  A 375 ( 0.7A)
GLN  A 371 ( 0.6A)
THR  A  37 ( 0.8A)
 1.26A 2hkkA-3r6yA:
undetectable		 2hkkA-3r6yA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 11 HIS A 150
ASN A 359
PHE A 366
ASN A 226
ASP A 266
 HIS  A 150 ( 1.0A)
ASN  A 359 ( 0.6A)
PHE  A 366 ( 1.3A)
ASN  A 226 ( 0.6A)
ASP  A 266 ( 0.6A)
 1.22A 2iyfA-3r6yA:
undetectable		 2iyfA-3r6yA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 6 ILE A 291
ARG A 296
ILE A 309
PHE A 201
 ILE  A 291 ( 0.7A)
ARG  A 296 ( 0.6A)
ILE  A 309 ( 0.7A)
PHE  A 201 ( 1.3A)
 1.14A 2q72A-3r6yA:
undetectable		 2q72A-3r6yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 12 PRO A 330
LEU A 311
ASN A 293
VAL A 181
LEU A 197
 PRO  A 330 ( 1.1A)
LEU  A 311 ( 0.6A)
ASN  A 293 ( 0.6A)
VAL  A 181 ( 0.6A)
LEU  A 197 ( 0.5A)
 1.11A 3a51B-3r6yA:
undetectable		 3a51B-3r6yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 9 ALA A  57
VAL A 135
GLY A  50
ILE A  82
ILE A  74
 ALA  A  57 ( 0.0A)
VAL  A 135 ( 0.6A)
GLY  A  50 ( 0.0A)
ILE  A  82 ( 0.7A)
ILE  A  74 ( 0.7A)
 1.12A 3ekvB-3r6yA:
undetectable		 3ekvB-3r6yA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 8 ASP A  93
GLY A 100
SER A 102
ILE A 103
 ASP  A  93 ( 0.5A)
GLY  A 100 ( 0.0A)
SER  A 102 ( 0.0A)
ILE  A 103 ( 0.6A)
 0.69A 3ihzB-3r6yA:
undetectable		 3ihzB-3r6yA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 11 GLN A 139
THR A 141
ALA A 144
LEU A  49
ASN A 136
 GLN  A 139 ( 0.6A)
THR  A 141 ( 0.8A)
ALA  A 144 ( 0.0A)
LEU  A  49 ( 0.6A)
ASN  A 136 ( 0.6A)
 1.24A 4claA-3r6yA:
undetectable		 4claA-3r6yA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 7 MET A 298
VAL A 310
PHE A 178
GLU A 308
 MET  A 298 ( 0.0A)
VAL  A 310 ( 0.6A)
PHE  A 178 ( 1.3A)
GLU  A 308 ( 0.6A)
 1.43A 4cttA-3r6yA:
undetectable
4cttB-3r6yA:
undetectable		 4cttA-3r6yA:
22.39
4cttB-3r6yA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 10 ALA A  57
VAL A 135
GLY A  50
ILE A  82
ILE A  74
 ALA  A  57 ( 0.0A)
VAL  A 135 ( 0.6A)
GLY  A  50 ( 0.0A)
ILE  A  82 ( 0.7A)
ILE  A  74 ( 0.7A)
 1.10A 4dqcA-3r6yA:
undetectable		 4dqcA-3r6yA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 12 LEU A 160
ILE A 373
ILE A 215
ALA A 280
GLY A 342
 LEU  A 160 ( 0.6A)
ILE  A 373 ( 0.7A)
ILE  A 215 ( 0.7A)
ALA  A 280 ( 0.0A)
GLY  A 342 ( 0.0A)
 1.16A 4enhA-3r6yA:
undetectable		 4enhA-3r6yA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 6 LEU A 369
MET A 376
LEU A 157
ILE A 151
 LEU  A 369 ( 0.5A)
MET  A 376 ( 0.0A)
LEU  A 157 ( 0.6A)
ILE  A 151 ( 0.6A)
 1.11A 4okxA-3r6yA:
2.0		 4okxA-3r6yA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 10 ALA A  57
VAL A 135
GLY A  50
ILE A  82
ILE A  74
 ALA  A  57 ( 0.0A)
VAL  A 135 ( 0.6A)
GLY  A  50 ( 0.0A)
ILE  A  82 ( 0.7A)
ILE  A  74 ( 0.7A)
 1.07A 4q1wB-3r6yA:
undetectable		 4q1wB-3r6yA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 12 ASN A 136
VAL A 135
LEU A 250
ALA A  57
GLY A 228
 ASN  A 136 ( 0.6A)
VAL  A 135 ( 0.6A)
LEU  A 250 ( 0.6A)
ALA  A  57 ( 0.0A)
GLY  A 228 ( 0.0A)
 1.22A 4qckA-3r6yA:
undetectable		 4qckA-3r6yA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 7 MET A 298
VAL A 310
PHE A 178
GLU A 308
 MET  A 298 ( 0.0A)
VAL  A 310 ( 0.6A)
PHE  A 178 ( 1.3A)
GLU  A 308 ( 0.6A)
 1.39A 4upnA-3r6yA:
undetectable
4upnB-3r6yA:
1.3		 4upnA-3r6yA:
22.39
4upnB-3r6yA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 7 GLY A 354
GLN A 355
SER A 351
ASN A 359
 GLY  A 354 ( 0.0A)
GLN  A 355 ( 0.6A)
SER  A 351 ( 0.0A)
ASN  A 359 ( 0.6A)
 0.95A 4ws0A-3r6yA:
undetectable		 4ws0A-3r6yA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 8 GLY A 354
GLN A 355
SER A 351
ASN A 359
 GLY  A 354 ( 0.0A)
GLN  A 355 ( 0.6A)
SER  A 351 ( 0.0A)
ASN  A 359 ( 0.6A)
 0.94A 4ws1A-3r6yA:
undetectable		 4ws1A-3r6yA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		3 / 3 ARG A 210
ASN A 287
ASP A 294
 ARG  A 210 ( 0.6A)
ASN  A 287 ( 0.6A)
ASP  A 294 ( 0.6A)
 0.78A 5gwxA-3r6yA:
undetectable		 5gwxA-3r6yA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 7 MET A 298
VAL A 310
PHE A 178
GLU A 308
 MET  A 298 ( 0.0A)
VAL  A 310 ( 0.6A)
PHE  A 178 ( 1.3A)
GLU  A 308 ( 0.6A)
 1.40A 5vusA-3r6yA:
undetectable
5vusB-3r6yA:
undetectable		 5vusA-3r6yA:
22.39
5vusB-3r6yA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 8 TYR A 274
ILE A 347
LEU A 156
ALA A 152
LEU A  45
 TYR  A 274 ( 1.3A)
ILE  A 347 ( 0.7A)
LEU  A 156 ( 0.6A)
ALA  A 152 ( 0.0A)
LEU  A  45 ( 0.6A)
 1.15A 5y7pE-3r6yA:
undetectable		 5y7pE-3r6yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 7 MET A 298
VAL A 310
PHE A 178
GLU A 308
 MET  A 298 ( 0.0A)
VAL  A 310 ( 0.6A)
PHE  A 178 ( 1.3A)
GLU  A 308 ( 0.6A)
 1.43A 6av1A-3r6yA:
undetectable
6av1B-3r6yA:
undetectable		 6av1A-3r6yA:
12.98
6av1B-3r6yA:
12.98