SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		5 / 12 VAL A 205
VAL A  36
LEU A  34
LEU A 111
MET A  39
 None
 1.49A 1mx1E-3r77A:
undetectable		 1mx1E-3r77A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		4 / 8 TYR A  10
TRP A 186
LEU A 172
MET A 189
 None
 1.10A 1uw6A-3r77A:
undetectable
1uw6B-3r77A:
undetectable		 1uw6A-3r77A:
23.71
1uw6B-3r77A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		4 / 8 TYR A  10
TRP A 186
LEU A 172
MET A 189
 None
 1.12A 1uw6D-3r77A:
undetectable
1uw6E-3r77A:
undetectable		 1uw6D-3r77A:
23.71
1uw6E-3r77A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		4 / 8 TYR A  10
TRP A 186
LEU A 172
MET A 189
 None
 1.14A 1uw6G-3r77A:
undetectable
1uw6H-3r77A:
undetectable		 1uw6G-3r77A:
23.71
1uw6H-3r77A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		4 / 8 TYR A  10
TRP A 186
LEU A 172
MET A 189
 None
 1.11A 1uw6P-3r77A:
undetectable
1uw6Q-3r77A:
undetectable		 1uw6P-3r77A:
23.71
1uw6Q-3r77A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		4 / 8 TRP A 186
LEU A 172
MET A 189
TYR A  10
 None
 1.09A 1uw6P-3r77A:
undetectable
1uw6T-3r77A:
undetectable		 1uw6P-3r77A:
23.71
1uw6T-3r77A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		3 / 3 PRO A  79
PHE A 129
LYS A 122
 None
None
QLI  A 500 (-2.6A)
 1.02A 3bjwG-3r77A:
undetectable		 3bjwG-3r77A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		4 / 4 LEU A 145
ALA A  74
VAL A  73
PRO A  72
 None
 1.24A 3gv1B-3r77A:
undetectable		 3gv1B-3r77A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		5 / 12 CYH A 148
VAL A  71
LEU A 137
LEU A 172
ALA A 176
 None
 1.12A 4rtbA-3r77A:
undetectable		 4rtbA-3r77A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		4 / 4 SER A 126
ALA A 127
GLN A  78
THR A  76
 None
None
QLI  A 500 (-3.0A)
None
 1.45A 5n0sA-3r77A:
1.2		 5n0sA-3r77A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		4 / 4 SER A 126
ALA A 127
GLN A  78
THR A  76
 None
None
QLI  A 500 (-3.0A)
None
 1.45A 5n0wA-3r77A:
1.2		 5n0wA-3r77A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3r77 PROBABLE
ISOCHORISMATASE
(Pseudomonas
fluorescens) 		4 / 4 SER A 126
ALA A 127
GLN A  78
THR A  76
 None
None
QLI  A 500 (-3.0A)
None
 1.45A 5n0xA-3r77A:
1.3		 5n0xA-3r77A:
19.22