SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		3 / 3 ALA A 334
VAL A 336
TRP A 326
 None
 0.92A 1tkqA-3r7kA:
undetectable		 1tkqA-3r7kA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 7 GLY A 181
ALA A 230
LEU A 219
SER A 143
 None
 0.84A 2wekB-3r7kA:
undetectable		 2wekB-3r7kA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 7 VAL A 239
ASN A 172
GLY A 173
VAL A 191
 None
 0.86A 2y05A-3r7kA:
undetectable
2y05B-3r7kA:
undetectable		 2y05A-3r7kA:
23.65
2y05B-3r7kA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 11 ALA A 285
ARG A 286
ILE A 357
LEU A 305
LEU A 278
 None
 1.04A 3kw2B-3r7kA:
undetectable		 3kw2B-3r7kA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 7 HIS A 112
LEU A 109
GLY A 142
PHE A 186
 None
 0.96A 3tehB-3r7kA:
undetectable		 3tehB-3r7kA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 THR A 229
ARG A 225
ARG A 217
ASP A 220
GLU A 231
 FDA  A 420 ( 4.4A)
None
None
None
None
 1.42A 3tkaA-3r7kA:
undetectable		 3tkaA-3r7kA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 THR A 229
ARG A 225
GLY A 104
ASP A 220
GLU A 231
 FDA  A 420 ( 4.4A)
None
None
None
None
 1.38A 3tkaA-3r7kA:
undetectable		 3tkaA-3r7kA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 5 PHE A 213
GLY A 142
ILE A 206
VAL A 205
 None
 0.81A 3wrkA-3r7kA:
undetectable		 3wrkA-3r7kA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 PHE A 234
SER A 216
GLU A  56
ASP A 228
GLY A 181
 None
 1.43A 4qb9E-3r7kA:
undetectable		 4qb9E-3r7kA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 10 TYR A 169
LEU A 158
ALA A 156
ALA A 190
GLY A 200
 None
 1.14A 4rn6A-3r7kA:
undetectable		 4rn6A-3r7kA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 6 ASP A 228
ALA A 184
THR A 179
THR A 111
 None
None
FDA  A 420 (-4.0A)
None
 1.40A 4w5qA-3r7kA:
undetectable		 4w5qA-3r7kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 6 ASP A 228
ALA A 184
THR A 179
THR A 111
 None
None
FDA  A 420 (-4.0A)
None
 1.35A 4w5rA-3r7kA:
undetectable		 4w5rA-3r7kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 6 ASP A 228
ALA A 184
THR A 179
THR A 111
 None
None
FDA  A 420 (-4.0A)
None
 1.37A 4w5tA-3r7kA:
undetectable		 4w5tA-3r7kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 6 ASP A 228
ALA A 184
THR A 179
THR A 111
 None
None
FDA  A 420 (-4.0A)
None
 1.35A 4z4cA-3r7kA:
undetectable		 4z4cA-3r7kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 6 ASP A 228
ALA A 184
THR A 179
THR A 111
 None
None
FDA  A 420 (-4.0A)
None
 1.37A 4z4fA-3r7kA:
undetectable		 4z4fA-3r7kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 5 ASP A 228
ALA A 184
THR A 179
THR A 111
 None
None
FDA  A 420 (-4.0A)
None
 1.38A 4z4gA-3r7kA:
undetectable		 4z4gA-3r7kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 6 ASP A 228
ALA A 184
THR A 179
THR A 111
 None
None
FDA  A 420 (-4.0A)
None
 1.39A 4z4iA-3r7kA:
undetectable		 4z4iA-3r7kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A 145
LEU A 232
GLY A 181
THR A 179
LEU A 144
 FDA  A 420 ( 4.3A)
None
None
FDA  A 420 (-4.0A)
None
 1.11A 5hg0A-3r7kA:
undetectable		 5hg0A-3r7kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 5 MET A 308
VAL A 312
GLY A 275
ALA A 274
 None
 1.05A 5k50A-3r7kA:
undetectable		 5k50A-3r7kA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 9 ILE A 206
VAL A 191
THR A 160
ASN A 172
 None
 0.95A 5lg3I-3r7kA:
4.5		 5lg3I-3r7kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 LEU A 219
SER A 227
ARG A 183
GLY A 181
VAL A 182
 None
 1.20A 5o4yD-3r7kA:
undetectable
5o4yE-3r7kA:
undetectable		 5o4yD-3r7kA:
2.61
5o4yE-3r7kA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 LEU A 379
SER A 102
ARG A 371
GLY A 104
GLY A 223
 None
 1.32A 5o4yD-3r7kA:
undetectable
5o4yE-3r7kA:
undetectable		 5o4yD-3r7kA:
2.61
5o4yE-3r7kA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 8 GLY A 181
GLU A  56
ILE A 141
ASP A 185
 None
 1.00A 5vlmD-3r7kA:
2.5		 5vlmD-3r7kA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3r7k PROBABLE ACYL COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		3 / 3 ARG A 192
PHE A 234
LEU A 158
 None
 0.86A 5x1bC-3r7kA:
3.5		 5x1bC-3r7kA:
19.51