SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		3 / 3 ALA A 182
VAL A 177
TRP A 176
 None
 0.82A 1kqeA-3r7pA:
undetectable
1kqeE-3r7pA:
undetectable		 1kqeA-3r7pA:
4.65
1kqeE-3r7pA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		3 / 3 ALA A 182
VAL A 177
TRP A 176
 None
 0.79A 1kqeB-3r7pA:
undetectable
1kqeD-3r7pA:
undetectable		 1kqeB-3r7pA:
4.65
1kqeD-3r7pA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		3 / 3 TRP A 176
ALA A 182
VAL A 177
 None
 0.81A 1kqeB-3r7pA:
undetectable
1kqeD-3r7pA:
undetectable		 1kqeB-3r7pA:
4.65
1kqeD-3r7pA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		3 / 3 TRP A 176
ALA A 182
VAL A 177
 None
 0.79A 1kqeA-3r7pA:
undetectable
1kqeE-3r7pA:
undetectable		 1kqeA-3r7pA:
4.65
1kqeE-3r7pA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		5 / 12 LEU A  34
THR A  35
LEU A 147
LEU A 137
GLY A 146
 None
 1.05A 2ouzA-3r7pA:
undetectable		 2ouzA-3r7pA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		4 / 8 LEU A 143
LEU A 114
LYS A 117
ALA A 118
 None
 0.62A 2wekA-3r7pA:
undetectable		 2wekA-3r7pA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		3 / 3 LEU A 104
TRP A 176
GLY A 179
 None
 0.78A 3l35A-3r7pA:
undetectable
3l35H-3r7pA:
undetectable		 3l35A-3r7pA:
8.92
3l35H-3r7pA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		3 / 3 LEU A 104
TRP A 176
GLY A 179
 None
 0.76A 3l35B-3r7pA:
undetectable
3l35K-3r7pA:
undetectable		 3l35B-3r7pA:
8.92
3l35K-3r7pA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		5 / 9 PHE A 207
THR A 181
GLN A 208
GLY A 185
ARG A 234
 None
 1.27A 4acaB-3r7pA:
undetectable
4acaC-3r7pA:
undetectable		 4acaB-3r7pA:
22.24
4acaC-3r7pA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		5 / 10 LEU A 139
HIS A 127
LEU A 121
ALA A 118
LEU A  34
 None
 1.28A 4p65A-3r7pA:
undetectable
4p65B-3r7pA:
undetectable
4p65F-3r7pA:
undetectable
4p65H-3r7pA:
undetectable		 4p65A-3r7pA:
8.44
4p65B-3r7pA:
9.90
4p65F-3r7pA:
9.90
4p65H-3r7pA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		4 / 6 SER A  66
GLU A  69
GLY A 183
GLY A 179
 None
None
MN  A 316 ( 4.6A)
None
 0.92A 5cdnR-3r7pA:
2.2
5cdnS-3r7pA:
undetectable		 5cdnR-3r7pA:
22.02
5cdnS-3r7pA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Leptographium
truncatum) 		4 / 7 ILE A 189
GLU A 292
HIS A 293
VAL A 203
 None
 1.18A 6j20A-3r7pA:
undetectable		 6j20A-3r7pA:
20.54