SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 8 SER A  17
SER A  20
GLY A  64
GLY A  13
 GNP  A 500 (-3.6A)
MG  A 600 ( 2.0A)
GNP  A 500 (-3.8A)
None
 0.70A 1f5lA-3r7wA:
undetectable		 1f5lA-3r7wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		5 / 9 CYH A 284
LEU A 207
LEU A 193
ILE A 199
ILE A 302
 None
 1.34A 1hzeA-3r7wA:
undetectable
1hzeB-3r7wA:
undetectable		 1hzeA-3r7wA:
15.72
1hzeB-3r7wA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 302
CYH A 284
LEU A 207
LEU A 193
ILE A 199
 None
 1.34A 1hzeA-3r7wA:
undetectable
1hzeB-3r7wA:
undetectable		 1hzeA-3r7wA:
15.72
1hzeB-3r7wA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		5 / 10 CYH A 284
LEU A 207
LEU A 193
ILE A 199
ILE A 302
 None
 1.32A 1i18A-3r7wA:
undetectable
1i18B-3r7wA:
undetectable		 1i18A-3r7wA:
15.72
1i18B-3r7wA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 302
CYH A 284
LEU A 207
LEU A 193
ILE A 199
 None
 1.31A 1i18A-3r7wA:
undetectable
1i18B-3r7wA:
undetectable		 1i18A-3r7wA:
15.72
1i18B-3r7wA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3r7w GTP-BINDING PROTEIN
GTR1
GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 SER B 273
PHE A 213
VAL B 237
PHE B 234
 None
 1.25A 1oipA-3r7wB:
undetectable		 1oipA-3r7wB:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 6 SER A  17
SER A  20
GLY A  64
GLY A  13
 GNP  A 500 (-3.6A)
MG  A 600 ( 2.0A)
GNP  A 500 (-3.8A)
None
 0.79A 2otvA-3r7wA:
undetectable		 2otvA-3r7wA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 8 SER A  17
SER A  20
GLY A  64
GLY A  13
 GNP  A 500 (-3.6A)
MG  A 600 ( 2.0A)
GNP  A 500 (-3.8A)
None
 0.76A 2vinA-3r7wA:
undetectable		 2vinA-3r7wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 286
LEU A 297
LEU A 288
ILE A 293
LEU A 299
 None
 1.26A 3a50E-3r7wA:
undetectable		 3a50E-3r7wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 248
THR A  35
SER A  31
ARG A  36
 None
GNP  A 500 (-4.2A)
None
None
 1.46A 3hlwB-3r7wA:
undetectable		 3hlwB-3r7wA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3r7w GTP-BINDING PROTEIN
GTR1
GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG A  37
ASP B 168
GLN B 226
 None
 0.93A 3lcvB-3r7wA:
2.6		 3lcvB-3r7wA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 179
VAL B  29
SER B 212
 None
 0.75A 3n8xB-3r7wB:
undetectable		 3n8xB-3r7wB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 206
TYR B 215
GLU B 233
PHE B 234
ILE B 295
 None
 1.38A 3ndiA-3r7wB:
undetectable		 3ndiA-3r7wB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		5 / 9 LEU B  63
LEU B  79
ILE B 119
PHE B  70
GLU B  77
 None
 1.16A 3tmzA-3r7wB:
undetectable		 3tmzA-3r7wB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 208
SER B 232
TYR B 228
SER B 212
VAL B  29
 None
 1.39A 3u9fD-3r7wB:
undetectable
3u9fE-3r7wB:
undetectable		 3u9fD-3r7wB:
19.70
3u9fE-3r7wB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		5 / 10 PHE B 208
SER B 232
TYR B 228
SER B 212
VAL B  29
 None
 1.45A 3u9fI-3r7wB:
undetectable		 3u9fI-3r7wB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_M_CLMM221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		5 / 10 PHE B 208
SER B 232
TYR B 228
SER B 212
VAL B  29
 None
 1.40A 3u9fM-3r7wB:
0.0
3u9fN-3r7wB:
0.0		 3u9fM-3r7wB:
19.70
3u9fN-3r7wB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		4 / 5 TYR B 111
ILE B 107
ASN B 114
ILE B 119
 None
 1.04A 4jtpA-3r7wB:
undetectable		 4jtpA-3r7wB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 113
LYS A 114
LYS A 110
 None
 1.15A 4k50A-3r7wA:
undetectable		 4k50A-3r7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 113
LYS A 114
LYS A 110
 None
 1.09A 4k50I-3r7wA:
undetectable		 4k50I-3r7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		4 / 7 ASN B 211
LEU B  55
ILE B 214
VAL B 216
 None
 0.84A 4ojbA-3r7wB:
undetectable		 4ojbA-3r7wB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 183
TYR B 215
VAL B 223
SER B 176
LEU B 193
 None
 1.41A 4qztA-3r7wB:
1.7		 4qztA-3r7wB:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 159
MET A 143
LEU A 125
HIS A  89
 None
 1.37A 4xi3B-3r7wA:
undetectable		 4xi3B-3r7wA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		3 / 3 MET A 282
HIS A 189
GLY A  53
 None
 0.82A 5gwzB-3r7wA:
undetectable		 5gwzB-3r7wA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		4 / 6 HIS B 124
LEU B 122
CYH B  26
LEU B  14
 GNP  B 500 (-3.7A)
None
None
None
 1.40A 5hrqD-3r7wB:
undetectable
5hrqG-3r7wB:
undetectable
5hrqH-3r7wB:
undetectable		 5hrqD-3r7wB:
5.54
5hrqG-3r7wB:
5.70
5hrqH-3r7wB:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 215
ILE A 216
LEU A  52
PHE A  51
ILE A 160
 None
 1.34A 5hw8C-3r7wA:
undetectable
5hw8H-3r7wA:
undetectable		 5hw8C-3r7wA:
18.43
5hw8H-3r7wA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		5 / 12 CYH A 284
LEU A 278
LEU A 193
ASN A 192
ILE A 286
 None
 1.09A 5mioB-3r7wA:
5.3		 5mioB-3r7wA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 125
LEU A 124
TRP A 175
 None
 0.74A 5nwuA-3r7wA:
undetectable		 5nwuA-3r7wA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		4 / 6 ILE B 119
LEU B  86
PHE B  80
PHE B 161
 None
 1.03A 5vkqB-3r7wB:
undetectable
5vkqC-3r7wB:
undetectable		 5vkqB-3r7wB:
12.83
5vkqC-3r7wB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  26
LEU A 125
PRO A 163
THR A 164
LEU A 171
 None
 1.26A 5xxiA-3r7wA:
undetectable		 5xxiA-3r7wA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 127
GLY A  16
ASP A  66
MET A  69
 GNP  A 500 (-3.6A)
GNP  A 500 (-3.8A)
None
None
 1.25A 6ag0A-3r7wA:
undetectable		 6ag0A-3r7wA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3r7w GTP-BINDING PROTEIN
GTR1
GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ILE A 268
GLN A 295
GLU B 304
VAL B 272
 None
 1.16A 6j20A-3r7wA:
undetectable		 6j20A-3r7wA:
20.44