SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 LEU A  85
LEU A  62
THR A  53
ILE A  49
LEU A 253
 None
 1.02A 1qzfA-3r89A:
undetectable		 1qzfA-3r89A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 LEU A  85
LEU A  62
THR A  53
ILE A  49
LEU A 253
 None
 1.03A 1qzfB-3r89A:
undetectable		 1qzfB-3r89A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 LEU A  85
LEU A  62
THR A  53
ILE A  49
LEU A 253
 None
 1.03A 1qzfC-3r89A:
undetectable		 1qzfC-3r89A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 LEU A  85
LEU A  62
THR A  53
ILE A  49
LEU A 253
 None
 1.02A 1qzfD-3r89A:
undetectable		 1qzfD-3r89A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 LEU A  85
LEU A  62
THR A  53
ILE A  49
LEU A 253
 None
 1.03A 1qzfE-3r89A:
undetectable		 1qzfE-3r89A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		4 / 4 ASP A 120
LEU A  90
LEU A  85
LEU A  91
 None
 1.28A 1u18A-3r89A:
undetectable		 1u18A-3r89A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 LEU A  85
LEU A  62
THR A  53
ILE A  49
LEU A 253
 None
 1.06A 2oipA-3r89A:
undetectable		 2oipA-3r89A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 LEU A  85
LEU A  62
THR A  53
ILE A  49
LEU A 253
 None
 1.07A 2oipD-3r89A:
undetectable		 2oipD-3r89A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 LEU A  85
LEU A  62
THR A  53
ILE A  49
LEU A 253
 None
 0.93A 2oipE-3r89A:
undetectable		 2oipE-3r89A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		4 / 5 GLY A 243
GLY A 244
PHE A 121
PHE A 148
 None
 0.98A 2qr2A-3r89A:
undetectable
2qr2B-3r89A:
undetectable		 2qr2A-3r89A:
24.26
2qr2B-3r89A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		4 / 6 PHE A 121
ILE A  59
PHE A 148
GLY A 244
 None
 0.75A 2qx6A-3r89A:
undetectable
2qx6B-3r89A:
undetectable		 2qx6A-3r89A:
24.26
2qx6B-3r89A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		4 / 6 GLY A 240
GLY A  15
PHE A 218
PHE A 192
 None
 1.00A 2qx6A-3r89A:
undetectable
2qx6B-3r89A:
undetectable		 2qx6A-3r89A:
24.26
2qx6B-3r89A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		3 / 3 MET A 107
VAL A 147
GLU A 134
 None
 0.69A 2x9gA-3r89A:
2.8		 2x9gA-3r89A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		4 / 8 ILE A 221
PRO A 222
HIS A 203
VAL A 207
 None
 0.86A 3em0B-3r89A:
undetectable		 3em0B-3r89A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 LEU A  85
LEU A  62
THR A  53
ILE A  49
LEU A 253
 None
 1.09A 3hj3B-3r89A:
undetectable		 3hj3B-3r89A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		4 / 5 ILE A 140
MET A   1
ASN A  -1
PHE A 113
 None
 1.25A 3octA-3r89A:
undetectable		 3octA-3r89A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 9 ILE A  59
LEU A   7
ILE A 221
MET A 217
GLY A 196
 None
 1.30A 3sj4X-3r89A:
undetectable		 3sj4X-3r89A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 11 LEU A  85
LEU A  62
THR A  53
ILE A  49
LEU A 253
 None
 1.04A 3tqbA-3r89A:
undetectable		 3tqbA-3r89A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		4 / 7 LEU A 253
TYR A  66
ASP A  22
SER A 249
 None
 1.31A 4arcA-3r89A:
undetectable		 4arcA-3r89A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		3 / 3 ARG A 152
ASP A 230
GLN A 227
 None
 0.74A 4azsA-3r89A:
undetectable		 4azsA-3r89A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 9 GLY A 243
GLY A 244
PHE A 121
ILE A  59
PHE A 148
 None
 0.95A 4fgjA-3r89A:
undetectable
4fgjB-3r89A:
0.9		 4fgjA-3r89A:
24.03
4fgjB-3r89A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 11 PHE A 121
ILE A  59
PHE A 148
GLY A 243
GLY A 244
 None
 1.02A 4fglA-3r89A:
undetectable
4fglB-3r89A:
undetectable		 4fglA-3r89A:
24.03
4fglB-3r89A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		3 / 4 SER A 190
GLY A 146
GLU A 118
 None
 0.58A 4juoA-3r89A:
undetectable
4juoC-3r89A:
undetectable		 4juoA-3r89A:
21.86
4juoC-3r89A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 ILE A 221
VAL A 199
LEU A 151
LEU A 237
MET A 179
 None
 1.48A 4m11A-3r89A:
undetectable		 4m11A-3r89A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		4 / 5 GLU A 141
GLU A 138
GLU A 137
GLU A 134
 None
 1.32A 4r87E-3r89A:
undetectable		 4r87E-3r89A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 GLY A 243
GLY A 244
PHE A 121
ILE A  59
PHE A 148
 None
 1.01A 4zvmA-3r89A:
undetectable
4zvmB-3r89A:
undetectable		 4zvmA-3r89A:
24.26
4zvmB-3r89A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Anaerococcus
prevotii) 		5 / 12 TYR A  45
ILE A  49
LEU A  21
GLY A 223
PRO A 222
 None
 1.17A 5ienA-3r89A:
undetectable		 5ienA-3r89A:
20.08