SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 249
GLY A 248
LEU A 246
GLY A 281
LYS A 263
 None
 1.23A 1y4lA-3r8eA:
undetectable		 1y4lA-3r8eA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 11 LEU A 233
ILE A 236
VAL A 141
GLY A 140
LEU A 242
 None
 1.21A 2bxeA-3r8eA:
undetectable		 2bxeA-3r8eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 LEU A 233
ILE A 236
VAL A 141
GLY A 140
LEU A 242
 None
 1.13A 2bxeB-3r8eA:
undetectable		 2bxeB-3r8eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		4 / 6 LEU A 114
VAL A 239
MET A 240
ILE A 129
 None
 1.11A 2hyyC-3r8eA:
undetectable		 2hyyC-3r8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 ILE A   5
LEU A  79
SER A  43
LEU A  94
ILE A  63
 None
 1.16A 3cd2A-3r8eA:
undetectable		 3cd2A-3r8eA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		4 / 6 MET A 143
VAL A 141
LEU A 292
ILE A 129
 None
 0.85A 3gcsA-3r8eA:
undetectable		 3gcsA-3r8eA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 11 ASP A 215
SER A 194
LEU A 196
THR A 182
GLN A 185
 None
 1.13A 3mbhA-3r8eA:
undetectable		 3mbhA-3r8eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 ASP A 215
SER A 194
LEU A 196
THR A 182
GLN A 185
 None
 1.13A 3mbhB-3r8eA:
undetectable		 3mbhB-3r8eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 ASP A 215
SER A 194
LEU A 196
THR A 182
GLN A 185
 None
 1.15A 3mbhC-3r8eA:
undetectable		 3mbhC-3r8eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 ASP A 215
SER A 194
LEU A 196
THR A 182
GLN A 185
 None
 1.13A 3mbhD-3r8eA:
undetectable		 3mbhD-3r8eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 ASP A 215
SER A 194
LEU A 196
THR A 182
GLN A 185
 None
 1.12A 3mbhE-3r8eA:
undetectable		 3mbhE-3r8eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 11 ASP A 215
SER A 194
LEU A 196
THR A 182
GLN A 185
 None
 1.14A 3mbhF-3r8eA:
undetectable		 3mbhF-3r8eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		4 / 8 VAL A 237
VAL A 158
MET A 161
ILE A 129
 None
 1.00A 3remA-3r8eA:
undetectable		 3remA-3r8eA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		4 / 8 VAL A 237
VAL A 158
MET A 161
ILE A 129
 None
 0.97A 3remB-3r8eA:
undetectable		 3remB-3r8eA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		4 / 4 LEU A   3
GLY A  62
MET A  44
PHE A  98
 None
 1.40A 3vaqB-3r8eA:
undetectable		 3vaqB-3r8eA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		4 / 8 TRP A  34
ILE A  82
ASN A  81
GLY A   9
 None
 0.82A 3wxoA-3r8eA:
undetectable		 3wxoA-3r8eA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.92A 4ctjC-3r8eA:
undetectable		 4ctjC-3r8eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		4 / 5 GLY A 290
ASP A   6
GLU A 106
VAL A  76
 None
 1.09A 4nkvD-3r8eA:
undetectable		 4nkvD-3r8eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.88A 5ec8C-3r8eA:
undetectable		 5ec8C-3r8eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.89A 5ehiC-3r8eA:
undetectable		 5ehiC-3r8eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.96A 5eiwA-3r8eA:
undetectable		 5eiwA-3r8eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.89A 5ekxB-3r8eA:
undetectable		 5ekxB-3r8eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		4 / 4 LEU A 169
LEU A 233
GLY A 230
GLU A 231
 None
 1.03A 5hhjA-3r8eA:
undetectable		 5hhjA-3r8eA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		4 / 7 ILE A  38
GLY A  39
LEU A   3
PHE A  51
 None
 0.68A 5hieB-3r8eA:
undetectable		 5hieB-3r8eA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.79A 5wz1A-3r8eA:
undetectable		 5wz1A-3r8eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.79A 5wz1B-3r8eA:
undetectable		 5wz1B-3r8eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.79A 5wz1C-3r8eA:
undetectable		 5wz1C-3r8eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.76A 5wz1D-3r8eA:
undetectable		 5wz1D-3r8eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.77A 5wz1E-3r8eA:
undetectable		 5wz1E-3r8eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.76A 5wz1F-3r8eA:
undetectable		 5wz1F-3r8eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.80A 5wz1G-3r8eA:
undetectable		 5wz1G-3r8eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 115
GLY A  62
GLY A 290
GLU A 106
ILE A 298
 None
 0.76A 5wz1H-3r8eA:
undetectable		 5wz1H-3r8eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 3r8e HYPOTHETICAL SUGAR
KINASE
(Cytophaga
hutchinsonii) 		5 / 12 LEU A 247
LEU A 131
GLY A 226
GLY A 230
ASN A 244
 None
 1.04A 6ce2B-3r8eA:
undetectable		 6ce2B-3r8eA:
13.55