SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 PHE A 308
VAL A 248
VAL A 275
ILE A 273
 None
 0.93A 1p7rA-3r8xA:
undetectable		 1p7rA-3r8xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		5 / 10 ILE A 139
PHE A   9
LEU A  81
ILE A 137
GLY A  11
 None
 1.27A 2v0mA-3r8xA:
undetectable		 2v0mA-3r8xA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		5 / 11 ILE A 273
LYS A 214
LEU A 287
ILE A 246
LEU A 314
 None
 1.31A 3a50C-3r8xA:
undetectable		 3a50C-3r8xA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 PRO A 103
ILE A 108
ASN A  82
LEU A 187
LEU A  23
 None
 1.11A 3a50E-3r8xA:
undetectable		 3a50E-3r8xA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		4 / 8 GLY A  21
LEU A  23
LEU A  24
ILE A  30
 None
 0.87A 3nbqB-3r8xA:
undetectable		 3nbqB-3r8xA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		4 / 8 GLY A  21
LEU A  23
LEU A  24
ILE A  30
 None
 0.89A 3nbqC-3r8xA:
undetectable		 3nbqC-3r8xA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		4 / 4 ASP A 143
LEU A 100
ARG A  70
THR A 148
 None
 1.49A 4kjjA-3r8xA:
undetectable		 4kjjA-3r8xA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		4 / 4 ASP A 143
LEU A 100
ARG A  70
THR A 148
 None
 1.50A 4kjkA-3r8xA:
undetectable		 4kjkA-3r8xA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 CYH A 107
ILE A 108
PRO A 103
ILE A   8
 None
 1.06A 4w5oA-3r8xA:
2.8		 4w5oA-3r8xA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 CYH A 107
ILE A 108
PRO A 103
ILE A   8
 None
 1.04A 4z4eA-3r8xA:
2.8		 4z4eA-3r8xA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 CYH A 107
ILE A 108
PRO A 103
ILE A   8
 None
 1.06A 4z4gA-3r8xA:
3.4		 4z4gA-3r8xA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		4 / 8 LEU A  55
GLY A  21
ALA A  22
SER A  25
 None
 0.65A 5f1aA-3r8xA:
undetectable		 5f1aA-3r8xA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 LEU A  55
GLY A  21
ALA A  22
SER A  25
 None
 0.64A 5f1aB-3r8xA:
undetectable		 5f1aB-3r8xA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 ASN A 302
ALA A 297
ILE A 273
LYS A 270
ALA A 268
 None
 1.01A 5xiwB-3r8xA:
undetectable		 5xiwB-3r8xA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3r8x METHIONYL-TRNA
FORMYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 TRP A 118
VAL A 128
SER A 165
THR A 164
PHE A 231
 None
None
None
MOE  A 323 ( 4.5A)
None
 1.46A 6drxA-3r8xA:
undetectable		 6drxA-3r8xA:
24.23